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  • 1
    Electronic Resource
    Electronic Resource
    Cytogenetic findings in 1250 chorionic villus samples obtained in the first trimester with clinical follow-up of the first 1000 pregnancies (1989)
    Oxford, UK : Blackwell Publishing Ltd
    BJOG 96 (1989), S. 0 
    Details
    ISSN: 1471-0528
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Summary. First-trimester chorionic villus sampling (CVS) was performed in a series of 1250 pregnancies. The direct method of karyotyping was successful in 1205 (96.4%). Abnormal laboratory findings resulted in 60 terminations of pregnancy (4.8%). In addition, six unexpected balanced chromosome rearrangements were detected. False-positive cytogenetic findings occurred in 2.3%, comprising 22 with mosaicism confined to the trophoblast, and a further six non-mosaic false-positive discrepancies were detected, four after termination of pregnancy. The outcome of the first 1000 pregnancies is known in all but one. There were no false-negative findings. Of 947 pregnancies meant to be continued, 34 (3.6%) ended in pregnancy loss before 28 weeks gestation. However, obstetricians with an experience of over 150 procedures had a pregnancy loss of 1.3%.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1471-0528.1989.tb03280.x
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  • 2
    Electronic Resource
    Electronic Resource
    HAEMOSTASIS IN MENSTRUAL ENDOMETRIUM IN THE PRESENCE OF AN INTRAUTERINE DEVICE (1981)
    Oxford, UK : Blackwell Publishing Ltd
    BJOG 88 (1981), S. 0 
    Details
    ISSN: 1471-0528
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The histology and ultrastructure of the haemostatic response in the endometrium have been studied in 12 uteri containing an inert or copper wound intrauterine contraceptive device (IUCD). The uteri were removed during the premenstrual phase or during the first 96 hours of menstruation. The results have been compared to earlier observations in non-IUCD influenced endometrium. In all uteri the tissue shedding proceeded more slowly in the presence of an IUCD and considerably fewer haemostatic plugs were found. The platelets in these plugs were more loosely packed and less degranulated, and the plugs contained less fibrin than in the absence of an IUCD. Haemostatic plugs were still observed at times when no such plugs were seen in uteri without an IUCD. Unoccluded vessel lesions were regularly seen and vessels open to the shedding surface were occasionally encountered. These observations suggest that IUCD-induced menorrhagia is caused by the combination of delayed shedding and a decreased haemostatic reaction in the endometrium.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1471-0528.1981.tb01310.x
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    MORPHOLOGY OF HAEMOSTASIS IN MENSTRUAL ENDOMETRIUM (1980)
    Oxford, UK : Blackwell Publishing Ltd
    BJOG 87 (1980), S. 0 
    Details
    ISSN: 1471-0528
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Light microscopy, electron microscopy and immunofluorescence were used to study the endometrium from nine uteri removed during the first 72 hours of normal menstruation. During premenstrual spotting, stromal disintegration and vessel lesions without any haemostatic reaction were seen. Up to 20 hours after the onset of menstrual bleeding, blood extravasation was prominent in the functional endometrium. The vessels in this layer were partly or totally sealed by intravascular thrombi functioning as haemostatic plugs. The thrombi contained various amounts of platelets and fibrin and were shed with the tissue. New plugs formed up-stream in the same vessels. Twenty hours after the onset of menstruation, most of the functional endometrium had been desquamated. From 20 to 72 hours after the start of menstrual bleeding no or few thrombi were seen. Haemostasis may then be caused by adherence of vessel lips.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1471-0528.1980.tb04573.x
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  • 4
    Electronic Resource
    Electronic Resource
    Idiopathic thrombocytopenic purpura in pregnancy: A randomized trial on the effect of antenatal low dose corticosteroids on neonatal platelet count (1990)
    Oxford, UK : Blackwell Publishing Ltd
    BJOG 97 (1990), S. 0 
    Details
    ISSN: 1471-0528
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Objective–To determine the efficacy of antenatal low dose oral betamethasone in preventing neonatal thrombocytopenia and/or bleeding in infants of mothers with idiopathic thrombocytopenic purpura (ITP). Setting–Hospital department of obstetrics and gynaecology, referral centre. Patients–41 pregnancies in 38 women were randomized. The results of 13 pregnancies were considered non-assessable. The final analysis involved 14 in the betamethasone group and 14 in the non-treatment group. All fulfilled the criteria for ITP. Interventions–The treated group received 1.5 mg betamethasone orally per day, from day 259 till day 273 and 1 mg from day 273 till delivery. Main outcome measures–Effects of treatment were assessed in terms of maternal platelet counts after the first trimester and neonatal platelet counts at birth and the first week of life and neonatal bleeding episodes. Results–There were no significant differences in neonatal platelet counts at birth. Two infants in the belamethasone group and one in the untreated group had a severe thrombocytopenia either at birth or during the first week of life (〈50 × 109/1). Seven infants in the betamethasone group and six in the nontreatment group had a mild thrombocytopenia. The overall frequency of neonatal thrombocytopenia was similar: 64% in the betamethasone group and 57% in the untreated group (95% CI of the true difference: –43.5% to +29.5%). There was also no significant difference in neonatal bleeding episodes. Conclusions–Low-dose betamethasone in pregnant women with TTP does not prevent thrombocytopenia or bleeding in their newborn infants.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1471-0528.1990.tb02443.x
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    Paper (German National Licenses)
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