ISSN:
1432-0843
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary The cytotoxic effects of ketoconazole, an antifungal agent known to have some activity against human prostate cancer, adrenal cancer, and male metastatic breast cancer, were evaluated using colony-growth and clonogenic assays in eight malignant cell lines. The cytotoxicity of ketoconazole showed a dose-and time-dependent pattern, with the following concentrations, inhibiting 90% of the growing colonies (IC90): MCF 7 (human breast cancer) 7.25 μg/ml, T 47 D (human breast cancer) 9.0 μg/ml, MiaPaCa (human pancreatic carcinoma) 10.0 μg/ml, COLO 357 (human pancreatic carcinoma) 9.5 μg/ml, HCT 8 (human colonic adenocarcinoma) 27.1 μg/ml, DU 145 (human prostatic cancer) 40.0 μg/ml, AR 42 J (rat pancreatic carcinoma) 9.0 μg/ml, and L1210 (murine leukemia) 8.6 μg/ml. Since a concentration of 10 μg/ml can be achieved in humans, the use of ketoconazole in human malignancies might be worthy of clinical evaluation.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00264198
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