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  • 1
    Electronic Resource
    Electronic Resource
    Biochemical Studies of Olfaction: Binding Specificity of Odorants to a Cilia Preparation from Rainbow Trout Olfactory Rosettes (1983)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of neurochemistry 41 (1983), S. 0 
    Details
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Abstract: Cilia isolated from the olfactory epithelium (olfactory rosettes) of rainbow trout (Salmo gairdneri) bind amino acids, which are odor stimuli to this species. We demonstrate that L-threonine, l-serine, and l-alanine bind to a common site, TSA, in the cilia preparation. All possible mixtures of two of the amino acids as competitors, with the third as the 3H-labeled ligand, were studied. The effect of two combined (unlabeled) competitors was always substantially less than additive compared with their actions singly. Along with additional inhibition studies using mixtures of inhibitors, the data show that the three odorants must interact with at least one common binding site, TSA. Binding of l-[3H]lysine to site L was unaffected by addition of l-threonine, l-serine, or l-alanine, establishing its independence from site TSA. l-Arginine inhibited binding of l-[3H]lysine, showing that both of these basic amino acids interact with site L. The data establish the presence, in trout olfactory cilia, of at least two separate and noninteracting populations of odorant binding sites, TSA and L.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1471-4159.1983.tb04777.x
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  • 2
    Electronic Resource
    Electronic Resource
    Subcellular Distribution of Glutamate Decarboxylase in Rat Olfactory Bulb: High Content in Dendrodendritic Synaptosomes (1980)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of neurochemistry 35 (1980), S. 0 
    Details
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: : The olfactory bulbs in the CNS contain reciprocal dendrodendritic synapses between the granule cells and the secondary dendrites of mitral cells. Based on pharmacologic and electrophysiologic evidence, these synapses are believed to utilize GABA as an inhibitory neurotransmitter. A dendrodendritic synaptosomal fraction has been isolated from rat olfactory bulbs. The upper portion (PB) of the crude nuclear pellet contains 30–40% of the GAD (glutamate decarboxylase) activity of the olfactory bulb homogenate. When PB is purified on a discontinuous sucrose density gradient, 78–85% of the GAD activity is localized to the region containing the dendrodendritic synaptosomes, which were identified by transmission electron microscopy. The presence of a substantial proportion of GAD, the enzyme that catalyzes synthesis of GABA, in the DDS provides neurochemical support for the hypothesis that GABA functions at the reciprocal dendrodendritic synapses in the olfactory bulb.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1471-4159.1980.tb03694.x
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  • 3
    Electronic Resource
    Electronic Resource
    Sequential order of skin responses to surfactants during a soap chamber test (1991)
    Oxford, UK : Blackwell Publishing Ltd
    Contact dermatitis 25 (1991), S. 0 
    Details
    ISSN: 1600-0536
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Differences in the response of distinct layers of the skin to surfactants were probed using a modification of the Frosch and Kligman soap chamber test. Soap and other surfactant-containing cleansers corneum is readily damaged even by a mild insult when no erythema is induced. A more severe treatment, such as 24-h exposure to a 5% solution, induced the maximal level of barrier damage but a submaximal level of erythema. Even 2 days of exposure to 5% soap does not elicit a maximal erythema response. These results suggest that the stratum corneum is more readily damaged than the dermis. Which is not unexpected because the stratum corneum is the readily damaged than the surfactant and skin. Furthermore, this study indicates that for discriminating among mild products, when a small degree of irritation is induced. The most effective measure is stratum corneum damage assessed by evaporimetry. However, for evaluating more irritating products, erythema is probably the more discriminating evaluation technique.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1600-0536.1991.tb01852.x
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  • 4
    Electronic Resource
    Electronic Resource
    Use of Monoclonal Antibodies to Characterize Amino Acid Taste Receptors in Catfish (1987)
    Oxford, UK : Blackwell Publishing Ltd
    Annals of the New York Academy of Sciences 510 (1987), S. 0 
    Details
    ISSN: 1749-6632
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Natural Sciences in General
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1749-6632.1987.tb43505.x
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  • 5
    Electronic Resource
    Electronic Resource
    Enzymic proteolysis of monellin. Absence of sweet peptides (1976)
    s.l. : American Chemical Society
    Journal of agricultural and food chemistry 24 (1976), S. 1075-1077 
    Details
    ISSN: 1520-5118
    Source: ACS Legacy Archives
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition , Process Engineering, Biotechnology, Nutrition Technology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/jf60207a024
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  • 6
    Electronic Resource
    Electronic Resource
    High Specific Binding of [3H]GABA and [3H]Muscimol to Membranes from Dendrodendritic Synaptosomes of the Rat Olfactory Bulb (1982)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of neurochemistry 39 (1982), S. 0 
    Details
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Abstract: Olfactory bulbs contain dendrodendritic synapses, which occur between granule cells and mitral cells, and γ-aminobutyric acid (GABA) is thought to act as an inhibitory neurotransmitter at these synapses. Synaptosomes derived from the dendrodendritic synapses of the olfactory bulb were shown previously to contain considerable L-glutamate decarboxylase activity. The subcellular distribution and binding parameters of [3H]GABA and [3H]muscimol binding sites have now been determined in the rat olfactory bulb. Of all fractions examined, crude synaptic membranes (CSM) prepared from the dendrodendritic synaptosomes were shown to have the highest specific binding activity and accounted for nearly all of the total binding activity for both ligands. The specific binding activities for [3H]GABA and for [3H]muscimol were greatly increased after treating the CSM with 0.05% Triton X-100. Binding was shown to be Na+-independent, reversible, pharmacologically specific, and saturable. High- and low-affinity sites were detected for both ligands, and both classes of sites had appreciably lower KD values for muscimol (KD1= 3.1 nM, KD2= 25.1 nM) than for GABA (KD1= 8.6 nM; KD2= 63.7 nM). The amounts of the high-affinity binding sites for muscimol and GABA were similar (Bmax= 1.7 and 1.5 pmol/mg protein, respectively). The results of the present experiments indicate that the GABA and muscimol binding sites represent the GABA postsynaptic receptor, presumably on mitral cell dendrites, and provide further support for the hypothesis that GABA functions as a neurotransmitter at the dendrodendritic synapses in the olfactory bulb.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1471-4159.1982.tb12581.x
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  • 7
    Electronic Resource
    Electronic Resource
    Enzymatic Basis of the Respiratory Stimulation During Phagocytosis (1964)
    [s.l.] : Nature Publishing Group
    Nature 204 (1964), S. 255-257 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] SEVERAL metabolic concomitants of phagocytosis have been observed1. One striking phenomenon in polymorphonuclear leucocytes (PMN) is an increased respiration during particle uptake2'3 which has been shown to be insensitive to 1 mM cyanide. It was""concluded that this increase in respiration is not ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/204255a0
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  • 8
    Electronic Resource
    Electronic Resource
    Enantiomeric Specificity of Alanine Taste Receptor Sites in Catfish (1987)
    Oxford, UK : Blackwell Publishing Ltd
    Annals of the New York Academy of Sciences 510 (1987), S. 0 
    Details
    ISSN: 1749-6632
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Natural Sciences in General
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1749-6632.1987.tb43500.x
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  • 9
    Electronic Resource
    Electronic Resource
    Monoclonal Antibodies Directed against Catfish Taste Receptors (1987)
    Oxford, UK : Blackwell Publishing Ltd
    Annals of the New York Academy of Sciences 510 (1987), S. 0 
    Details
    ISSN: 1749-6632
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Natural Sciences in General
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1749-6632.1987.tb43682.x
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  • 10
    Electronic Resource
    Electronic Resource
    Distribution of taste buds on fungiform and circumvallate papillae of bovine tongue (1979)
    New York, NY [u.a.] : Wiley-Blackwell
    The @Anatomical Record 195 (1979), S. 443-446 
    Details
    ISSN: 0003-276X
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine
    Notes: The distribution of taste buds on the fungiform and circumvallate papillae of the cow tongue has been determined. The two tongues studied were from Holstein-Friesian cows four to six years of age; they contained 14,765 and 21,691 taste buds, respectively. The tip of the tongue is well supplied with fungiform papillae, and the posterior portion contains the circumval-late papillae. The midportion of the tongue contains relatively few taste papillae.The fungiform papillae contained 1,580 and 1,838 taste buds on the two tongues, respectively, and the circumvallate papillae were estimated to contain 13,185 and 19,853 taste buds. The highest concentration of taste buds therefore occurs in the circumvallate papillae; these relatively few papillae contain approximately 90% of the taste buds. On a circumvallate papilla, taste buds are found only on the papillary sidewall, with none either on the apical surface of the papilla or on the outer wall of the moat.
    Additional Material: 2 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/ar.1091950304
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