ISSN:
1471-0528
Source:
Blackwell Publishing Journal Backfiles 1879-2005
Topics:
Medicine
Notes:
Objective To determine whether corticotrophin releasing hormone plays a role in the regulation of tone in tern nonlabouring human myometrium.Setting A teaching hospital research laboratory.Sample Thirty-seven women undergoing elective nonlabour caesarean section under regional anaesthesia.Methods Human corticotrophin releasing hormone (1, 10, 100 nmol/L) was added to strips of term, nonlabouring myometrium mounted in an organ bath, and the effect on spontaneous, oxytocin (1 nmol/L) or prostaglandin F2α (100 nmol/L) stimulated contractions determined. Cyclic adenosine monophosphate (CAMP) content of the tissue was also determined by enzyme immunoassay.Results Corticotrophin releasing hormone did not affect myometrial tension development in any of the experimental protocols. cAMP increased transiently after addition of corticotrophin releasing hormone (166.7 ± 12.7% at 1 minute) but this was not reflected by any change in tension.Conclusions This study suggests that despite high maternal plasma concentrations of corticotrophin releasing hormone in pregnancy at term, this peptide is unlikely to play a direct role in the control of myometrial contractility in nonlabouring myometrium.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1111/j.1471-0528.1999.tb08297.x
Permalink
