ISSN:
1573-3599
Keywords:
cystic fibrosis
;
screening
;
genetic counseling
;
mutation detection
;
polymerase chain reaction
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
,
Psychology
Notes:
Abstract Population-based screening for cystic fibrosis carrier mutations presents a number of challenges for genetic counselors, owing primarily to the inability of current DNA testing technology to identify all possible mutations and the difficulty involved in conveying the concept of residual risk to those patients who test negative. To address these issues, we are conducting a pilot study, as part of a consortium established by the National Center for Human Genome Research, to explore the efficacy, acceptance, and psychosocial impact of various approaches to carrier screening in an ethnically diverse Southern California population. This article reports the patient instructional and screening strategies we developed in the initial phase of the project in order to optimize our chances of answering these questions and delivering this service on a large scale.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01412373
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