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  • 1
    Electronic Resource
    Electronic Resource
    “Urbanization Influences on Aquatic Communities in Northeastern Illinois Streams,” by Faith A. Fitzpatrick, Mitchell A. Harris, Terri L. Arnold, and Kevin D. Richards (2005)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of the American Water Resources Association 41 (2005), S. 0 
    Details
    ISSN: 1752-1688
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Architecture, Civil Engineering, Surveying , Geography
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1752-1688.2005.tb03730.x
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  • 2
    Electronic Resource
    Electronic Resource
    Dental Health Education for All West Virginians I. Its Organization (1968)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of public health dentistry 28 (1968), S. 0 
    Details
    ISSN: 1752-7325
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The writers present the program of dental health education now instituted in West Virginia.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1752-7325.1968.tb01411.x
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  • 3
    Electronic Resource
    Electronic Resource
    Organizational Ecology (1984)
    Palo Alto, Calif. : Annual Reviews
    Annual Review of Sociology 10 (1984), S. 71-93 
    Details
    ISSN: 0360-0572
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Sociology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1146/annurev.so.10.080184.000443
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  • 4
    Electronic Resource
    Electronic Resource
    Modeling Internal Organizational Change (1995)
    Palo Alto, Calif. : Annual Reviews
    Annual Review of Sociology 21 (1995), S. 217-236 
    Details
    ISSN: 0360-0572
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Sociology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1146/annurev.so.21.080195.001245
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  • 5
    Electronic Resource
    Electronic Resource
    Peripheral Cardiovascular Effects in Rats after Central Administration of Histamine and Antihistamines (1979)
    Oxford, UK : Blackwell Publishing Ltd
    Clinical and experimental pharmacology and physiology 6 (1979), S. 0 
    Details
    ISSN: 1440-1681
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: 1. Vascularly isolated but nervously intact rat right hind limbs were perfused with blood at a constant flow rate and changes in perfusion pressure (proportional to vascular resistance), heart rate and blood pressure were monitored.2. Histamine administered into the right lateral cerebral ventricle (Lev.) through guide cannulae, induced dose-dependent increases in perfusion pressure, heart rate and blood pressure.3. Prior i.c.v. or i.v. administration of metiamide (an H2-antagonist) did not prevent the cardiovascular responses to i.c.v. histamine but rather prolonged them. Following i.c.v. or i.v. administration of chlorpheniramine (an Hrantagonist), however, changes in vascular resistance, heart rate and blood pressure were not significant.4. Metiamide administration appeared to have some agonist activity on its own. Thus the role of H2-receptors in cardiovascular responses to centrally administered histamine remains unclear.5. The work shows that in rats increases in nervous discharge to at least the hind limb vascular bed occur following central administration of histamine and confirms that increases occur in heart rate and blood pressure. These responses appear likely to be mediated through stimulation of central H1 receptors.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1440-1681.1979.tb00026.x
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  • 6
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    A Publisher's Views on Reviewing (1967)
    Ann Arbor, Mich., etc. : Periodicals Archive Online (PAO)
    Notes. [ser.2]:23:4 (1967:June) 693 
    Details
    ISSN: 0027-4380
    Topics: Musicology
    URL: http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&res_dat=xri:pao:&rft_dat=xri:pao:article:3179-1967-023-04-000003
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  • 7
    Electronic Resource
    Electronic Resource
    Antitumor drug cross-resistance in vivo in a murine P388 leukemia resistant to ethyl 5-amino-1,2-dihydro-2-methyl-3-phenylpyrido[3,4-b]pyrazin-7-ylcarbamate 2-hydroxyethanesulfonate hydrate (NSC 370 147) 370 147 (1992)
    Springer
    Cancer chemotherapy and pharmacology 29 (1992), S. 190-194 
    Details
    ISSN: 1432-0843
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Ethyl 5-amino-1,2-dihydro-2-methyl-3-phenylpyrido[3,4-b]pyrazin-7-ylcarbamate 2-hydroxyethanesulfonate hydrate (NSC 370 147) is a potent mitotic inhibitor, which has provided the basis for a candidate for clinical trial. As observed with clinically useful drugs, the development of clinical resistance to NSC 370 147 will probably be encountered. Information concerning resistance to NSC 370 147 should aid in the design of strategies for the opitmal clinical use of the drug. A P388 leukemia resistant to NSC 370 147 (P388/NSC 370 147) was isolated and its in vivo cross-resistance profile was determined. The P388/NSC 370 147 line was cross-resistant to vincristine but was not cross-resistant to doxorubicin, etoposide, cisplatin, melphalan, methotrexate, or 5-fluorouracil. This information plus other in vivo cross-resistance data [Waud et al. (1990) Cancer Res 50: 3239] suggests that NSC 370 147 may be useful in non-cross-resistant combinations with doxorubicin, melphalan, cisplatin, or methotrexate. The lack of cross-resistance of P388/NSC 370 147 to doxorubicin and etoposide shows that resistance to NSC 370 147 does not involve multidrug resistance and suggests that themdr1 gene is not involved in resistance to NSC 370 147.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00686251
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  • 8
    Electronic Resource
    Electronic Resource
    Antagonism of the IL-6 cytokine subfamily — a potential strategy for more effective therapy in rheumatoid arthritis (1998)
    Springer
    Inflammation research 47 (1998), S. 1-7 
    Details
    ISSN: 1420-908X
    Keywords: Key words: Cartilage — Joint — Leukocyte — Proteoglycan — Receptor
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract. Pro-inflammatory cytokines, some of which have the capacity to modulate cartilage and bone metabolism, are important mediators of the frequently sustained and destructive inflammation that characterises rheumatoid arthritis (RA). Tumour necrosis factor alpha (TNFα) and interleukin-1 (IL-1) have been studied extensively in this regard. That these proteins are important is no longer in doubt following the demonstration that the IL-1 receptor antagonist and neutralising antibodies directed against TNFα are clinically effective. Recent studies suggest that interleukin-6 (IL-6) and other members of the IL-6 cytokine subfamily are also potentially important cytokines in the pathogenesis of RA. The recognition of shared molecular subunits in the receptors for these cytokines raises the possibility that components of these receptors or their derivatives, either alone or in combination, may be useful for antagonising members of the IL-6 cytokine subfamily. Effective antagonism could be therapeutically beneficial in respect to attenuating inflammation and protecting critically important chondral and skeletal tissue. In this review the rationale and possible strategies for such antagonism are discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s000110050235
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  • 9
    Electronic Resource
    Electronic Resource
    A study of the fine structure of ascosporogenesis in Saccobolus kerverni (1969)
    Springer
    Archives of microbiology 66 (1969), S. 321-339 
    Details
    ISSN: 1432-072X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary Observations of ascospore fromation in KMnO4-fixed Saccobolus kerverni apothecia with the electron microscope reveal the following sequence. Ascus formation is preceded by the development of croziers whose fine structure differs little from that of vegetative hyphae. Following fusion of the two nuclei in the ascus mother cell, the resultant ascus elongates, and two large vacuoles appear, first below and later above the fusion nucleus. These vacuoles soon occupy dominant positions at the tip and bottom of the ascus and assume a flocculent appearance. Nuclear blebbing occurs during meiosis, mitosis, and the subsequent spore delimitation process in the central cytoplasmic portion of the ascus. Each spore initial is surrounded by two membranes, the plasma and investing membranes, between which the spore wall is deposited in two layers, an inner primary wall and an outer secondary wall. Following primary wall deposition the spores clump; secondary wall deposition begins outside the primary wall at the places where the spores are contiguous. Interdigitation of these walls and disappearance of the investing membranes in the sutures lead to the envelopment of all eight ascospores in a common secondary wall. A flocculent material in the epiplasmic vacuoles aggregates around the mature spore balls.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00414588
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  • 10
    Electronic Resource
    Electronic Resource
    Sulphasalazine versus penicillamine in the treatment of rheumatoid arthritis (1989)
    Springer
    Rheumatology international 8 (1989), S. 251-255 
    Details
    ISSN: 1437-160X
    Keywords: Sulphasalazine ; Penicillamine ; Rheumatoid arthritis ; Life-tables ; Radiological damage ; Acetylator phenotype
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Fifty-four patients with rheumatoid arthritis were randomized to either sulphasalazine or d-penicillamine in order to compare the short- and long-term efficacy of these two agents in the treatment of rheumatoid arthritis. Decisive improvement was observed in both treatment groups over a 1 year period. Side effects were common in both groups and accounted for termination of therapy in 11 patients during the first year. Radiological deterioration was evident in both treatment groups. A trend toward greater radiological deterioration was observed in patients receiving sulphasalazine, but this was not statistically significant. Only 11 of the 38 patients who completed 1 year of therapy were continuing to take the same drug 5 years later. Eight patients were continuing d-penicillamine and three were still taking sulphasalazine. Among the patients who completed 1 year of therapy, treatment was subsequently terminated because of loss of effective disease control in a significantly higher proportion of patients receiving sulphasalazine (P〈0.01). The radiological data and the latter observations suggest that d-penicillamine may be a more effective agent for long-term treatment.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00270980
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