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  • 1
    Electronic Resource
    Electronic Resource
    Coagulation factor III (tissue factor) interaction with phospholipid vesicles induced by cadmium: characterization of the reconstituted protein-membrane complex (1981)
    Springer
    Bioscience reports 1 (1981), S. 197-205 
    Details
    ISSN: 1573-4935
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology
    Notes: Abstract Coagulation factor III (tissue factor) is a membrane glycoprotein which serves as a cofactor in the proteolytic activation of factor X and factor IX by factor VIIa. Mixing of human placental factor III apoprotein with vesicles of bovine brain phospholipids does not produce significant reconstitution of factor III activity, but, when the mixture of apoprotein and vesicles is made 5 mM with CdCI2, the apoprotein is incorporated into the vesicles. Ultracentrifugation on sucrose density gradients demonstrated that the active factor III-lipid complex formed by reconstitution with vesicles had a density indistinguishable from that of the complex formed by detergent dialysis. Vesicles isolated after centrifugation were shown to range in diameter from 20 nm to over 100 nm using the electron microscope. Gel filtration showed that factor-III activity was associated with all size-classes of vesicles. The presence of factor III activity in the smaltest vesicles argues for a specific cadmium-mediated reconstitution of the apoprotein with phospholipid vesicles.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01114905
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Cadmium causes vesicle leakage under conditions which favor reconstitution of tissue factor-vesicle complexes (1983)
    Springer
    The journal of membrane biology 75 (1983), S. 123-127 
    Details
    ISSN: 1432-1424
    Keywords: tissue factor ; coagulation factor III ; cadmium ; membrane reconstitution ; vesicles
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology
    Notes: Summary Cadmium has a singular ability to promote the functional reconstitution of tissue factor (coagulation factor III) apoprotein with vesicles formed from mixed bovine brain lipids. Cadmium causes rapid release of carboxyfluorescein from lipid vesicles which chromatograph in the included volume of Bio Gel A5m, and also promotes reconstitution of tissue factor with these vesicles. With larger vesicles, which are excluded on Bio Gel A5m, cadmium produces only low levels of reconstitution and leakage. Calcium has been shown to promote only low levels of tissue factor-vesicle reconstitution, and produces only low levels of carboxyfluorescein leakage when compared to cadmium. These results demonstrate that cadmium and calcium interact differently with the small mixed lipid vesicles, and suggest that the cadmium-promoted reconstitution of tissue factor vesicle-complexes accompanies cadmium-induced alterations in vesicle structure. The results also show that cadmium affects large and small vesicles differently.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01995632
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Saturable Processes Affecting Renal Clearance of Cefixime in Dogs (1986)
    Springer
    Pharmaceutical research 3 (1986), S. 150-155 
    Details
    ISSN: 1573-904X
    Keywords: renal clearance ; cephalosporin ; cefixime ; tubular reabsorption ; saturable protein binding ; pharmacokinetics
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract The pharmacokinetics of cefixime, a new orally active cephalosporin, was studied after an intravenous dose of 50 mg/kg to four beagle dogs. Cefixime was shown to exhibit concentration dependent serum protein binding and saturable tubular reabsorption. The drug was excreted mainly in the urine, the net result of glomerular filtration and saturable tubular reabsorption. The experimental results were analyzed by model independent pharmacokinetic equations and with theoretical models describing renal clearance. Modification of the models, based on observed data, was proposed. The experimental methods employed and the pharmacokinetic approach offered in this study can be applied to drugs that exhibit concentration dependent protein binding and saturable renal elimination processes.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1016309923717
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Regional assignment of human tissue factor gene (F3) to chromosome 1p21-p22 (1988)
    Springer
    Somatic cell and molecular genetics 14 (1988), S. 407-410 
    Details
    ISSN: 1572-9931
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract Tissue factor, or coagulation factor III, is a membrane-bound glycoprotein and acts as a cofactor for factor VII-dependent initiation of blood coagulation. The tissue factor gene (F3) was previously assigned to human chromosome 1, region p21-pter. The present report has further refined the mapping position to 1p21-p22 using a cDNA probe for the tissue factor gene and in situ hybridization to metaphase chromosomes.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01534649
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    Paper (German National Licenses)
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