ISSN:
1573-6784
Source:
Springer Online Journal Archives 1860-2000
Topics:
Process Engineering, Biotechnology, Nutrition Technology
Notes:
Summary During the study of mevinolin biosynthesis by Aspergillus terreus ATCC 20542, 10 different medium components were selected for medium optimization. A new optimization method based on genetic algorithms and inductive learning was used for experimental design. For better efficiency the method was supported by a model, constructed with machine learning method, to predict the productivity. In four generations of fermentation experiments the productivity increased nearly three times.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00180409
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