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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Radiation and environmental biophysics 11 (1975), S. 319-325 
    ISSN: 1432-2099
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Physics
    Notes: Summary An alternative approach to the explanation and analysis of post-irradiation effects is presented. The analysis is based on the repair of a radiation-induced lesion and it is shown that the experimental results are compatible with the repair of one type of critical lesion involved in cell reproductive death. The nature of the lesion with respect to potentially lethal damage and sub-lethal damage is discussed.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Radiation and environmental biophysics 30 (1991), S. 169-171 
    ISSN: 1432-2099
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Physics
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    Radiation and environmental biophysics 37 (1998), S. 1-9 
    ISSN: 1432-2099
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Physics
    Notes: Abstract The Radiation Protection Research Unit of the European Commission has been supporting collaborative research projects on the radiological consequences of the Chernobyl accident since 1991. However, in the Fourth Framework Programme of the Commission which started in 1996, the collaboration with scientists in the former Soviet Union has been placed on a different footing, and the programme has been expanded to include other regions, especially in Russia and Kazakhstan, where previous nuclear incidents have led to the exposure of workers and the local populations and to widespread radioactive contamination. There are 15 projects on health-related studies in the newly started programme, and in order to improve the collaboration between the different scientists working in these projects a Cluster Contractors' Meeting was organised in San Miniato, Italy, in June 1997 with the participation of some 50 scientists from the European Union (EU) and the Newly Independent States (NIS). This report summarizes the different topics, including molecular biology and treatment of childhood thyroid cancer, various epidemiological studies and dose reconstruction, which were discussed at the meeting and which form the major projects in the new collaborative programme.
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Springer
    Radiation and environmental biophysics 39 (2000), S. 89-98 
    ISSN: 1432-2099
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Physics
    Notes: Abstract  The thyroid cancer data of children in the northern regions of the Ukraine after the reactor accident at Chernobyl were combined with thyroid dose measurements in the same regions and analysed using a two- mutation carcinogenesis model. The best fit was obtained for radiation acting as an initiating agent, i.e. on the first mutation of the model. The observed relatively high increase of thyroid cancer incidence after 1990 in children exposed to radiation released after the reactor accident could be ascribed to the high thyroid doses and the relatively low background thyroid cancer incidence in children. The maximum annual incidence is predicted to occur fairly soon after the reactor accident, i.e. about 10 years. For adults, the predicted relative increase of annual thyroid cancers is much lower than for children younger than 20 years. The modelling results are used to derive risk estimates for radiation-induced thyroid cancer. These risk estimates are dependent on age at exposure, follow-up time and the background thyroid cancer incidence. The calculated excess absolute risk for a population of all ages is about one-third of that currently used by ICRP, but for children the calculated absolute risks are about a factor of 3 higher than derived in other epidemiological studies. The model results indicate that the excess absolute radiation risk per unit dose for children is about the same as or a little lower than that for adults.
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Springer
    Theoretical and applied genetics 44 (1974), S. 167-172 
    ISSN: 1432-2242
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary This paper presents arguments which favour an alternative approach to the interpretation of radiation induced chromosome aberrations. Starting from the modern concept that a chromosome has a DNA double stranded helix backbone and that the induction of DNA double strand breaks has a quadratic dose relationship, it is concluded that most chromosome aberrations arise from only one chromosome break. The direct correlation between chromosome aberrations and cell death derived from the model is demonstrated by the analysis of experimental results. The effect of dose rate, LET and the occurrence of chromatid aberrations after irradiation in G1 are all logically explained by the theoretical model.
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    Springer
    Theoretical and applied genetics 47 (1976), S. 5-8 
    ISSN: 1432-2242
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary A direct mathematical relationship between mutation frequency per survivor and cell survival is derived from theoretical considerations of the molecular effects of radiation in a cell. It is shown that the relationship is satisfied by analysis of the various data on radiation induced mutations available in the literature. The analysis implies that a common type of lesion may lead to mutation and cell death and is derived on the assumption that radiation-induced double strand breaks in DNA are the critical lesions. The mathematical relationship is independent of the way in which the lesion which leads to mutations and cell death is induced, so the analysis has consequently been applied to other mutagenic treatments such as UV light and chemicals. It is concluded that, although the lesions induced by chemicals may not be the same as those induced by radiation, it is probable that for the chemicals considered common basic damage to the DNA molecule is implicated as the critical lesion.
    Type of Medium: Electronic Resource
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  • 7
    Electronic Resource
    Electronic Resource
    Springer
    Theoretical and applied genetics 52 (1978), S. 239-240 
    ISSN: 1432-2242
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Type of Medium: Electronic Resource
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  • 8
    Electronic Resource
    Electronic Resource
    Springer
    Theoretical and applied genetics 63 (1982), S. 234-234 
    ISSN: 1432-2242
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Type of Medium: Electronic Resource
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  • 9
    Electronic Resource
    Electronic Resource
    New York : Wiley-Blackwell
    Journal of Polymer Science Part A-1: Polymer Chemistry 10 (1972), S. 1679-1685 
    ISSN: 0449-296X
    Keywords: Physics ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: A correlation between the radiation-induced nine-line electron spin resonance signal and the unstable component of the optical absorption in the near ultraviolet in poly(methyl methacrylate) is made on the basis of the radiation dose relationship, the dependence of production on irradiation temperature at a constant radiation dose, and on the fading of both signals on oxygen diffusion into the poly(methyl methacrylate) after irradiation. It is concluded that this correlation is applicable only immediately after irradiation and the stability of the initial radical is discussed with respect to the fading results. A process of radical decay and conversion is suggested to account for differences found in the fading characteristics of the two signals.
    Additional Material: 6 Ill.
    Type of Medium: Electronic Resource
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