ISSN:
0749-1581
Keywords:
1H NMR assignments
;
3-methyl ethers of estrone and estradiol
;
14α-methyl analgoues
;
Chemistry
;
Analytical Chemistry and Spectroscopy
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
Notes:
The 500 MHz 1H spectra of the 3-methyl ethers of estrone, estradiol and their 14α-methyl analogues were assigned by proton decoupling and analysed by second-order calculations for chemical shifts and coupling constants. Introduction of a 14α-Me group effects consistent deshielding of 1,3 diaxially disposed protons. Coupling constant values show characteristic changes for ring D protons, and suggest that some minor perturbation in the H-9α, -11α, -11β region is caused by the additional methyl group.
Additional Material:
1 Ill.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/mrc.1260250909
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