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Effects of neutrophil adherence on the characteristics of receptors for tumor necrosis factor-α

Chamba, A. ; Stockley, R.A. ; Burnett, D.

Amsterdam : Elsevier

FEBS Letters 282 (1991), S. 373-376

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ISSN: 0014-5793

Keywords: Neutrophil ; Receptor ; Tumor necrosis factor

Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002

Topics: Biology , Chemistry and Pharmacology , Physics

Type of Medium: Electronic Resource

URL: http://linkinghub.elsevier.com/retrieve/pii/0014-5793(91)80516-6

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The effect ofin vitro andin vivo dexamethasone on human neutrophil function (1991)

Lomas, D. A. ; Ip, M. ; Chamba, A. ; [et al.]

Springer

Inflammation research 33 (1991), S. 279-285

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ISSN: 1420-908X

Source: Springer Online Journal Archives 1860-2000

Topics: Medicine

Notes: Abstract There is a significant fall in PMN chemotaxis to the peptide FMLP in response to increasing concentrations of dexamethasonein vitro. The response fell in a dose related manner from a control value of 53.7 SE±9.6 cells per high power field (cpf) to 47.3 SE±8.1 at 10−6 M (p〈0.05) and 24.7±8.9 at 10−3 M (p〈0.025). A similar response was observed for the chemoattractants zymosan activated serum and the sol phase of purulent sputum. The effect was independent of protein synthesis or the period of incubation. Twelve milligrams of dexamethasone taken daily by 6 healthy volunteers resulted in a significant (p〈0.025) reduction in the chemotactic response of PMN to 10−8 M FMLP (from 29.5±1.55 to 13.7±1.8 cpf) which was apparent within 2 hours of taking the first dose. This effect was sustained for the three days on which dexamethasone was taken but returned to normal 7 days after the last dose had been administered. Dexamethasone therapy had no effect on unstimulated PMN superoxide anion production eitherin vitro orin vivo. Thein vivo effect on neutrophil function occurred at mean serum dexamethasone concentrations of 1.26 (±0.28)×10−7 M on day 1, 1.44 (±0.15)×10−7 M on day 2 and 1.31 (±0.13)×10−7 M on day 3. Thus we conclude that dexamethasone concentration which inhibit PMN chemotaxisin vivo are much lower than those required to exert the same effectin vitro.