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  • 1
    Electronic Resource
    Electronic Resource
    Analysis of gene expression in normal and malignant lymphocytes using the Lymphochip cDNA microarray (1999)
    [s.l.] : Nature America, Inc.
    Nature genetics 23 (1999), S. 30-31 
    Details
    ISSN: 1546-1718
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Medicine
    Notes: [Auszug] Genome-wide knowledge of gene expression in cancer cells promises to illuminate many aspects of their clinical behaviour. We have begun a study of gene expression in lymphoid malignancies by constructing a specialized cDNA microarray, termed the ‘Lymphochip’, that is enriched in genes ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/14260
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  • 2
    Electronic Resource
    Electronic Resource
    Distinct types of diffuse large B-cell lymphoma identified by gene expression profiling (2000)
    [s.l.] : Macmillian Magazines Ltd.
    Nature 403 (2000), S. 503-511 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Diffuse large B-cell lymphoma (DLBCL), the most common subtype of non-Hodgkin's lymphoma, is clinically heterogeneous: 40% of patients respond well to current therapy and have prolonged survival, whereas the remainder succumb to the disease. We proposed that this variability in natural history ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/35000501
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  • 3
    Electronic Resource
    Electronic Resource
    Detection and Relevance of Minimal Disease in Lymphomas (1999)
    Springer
    Cancer and metastasis reviews 18 (1999), S. 127-142 
    Details
    ISSN: 1573-7233
    Keywords: non-Hodgkin's lymphoma ; Hodgkin's disease ; minimal residual disease (MRD) ; culture/molecular detection
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The detection and clinical relevance of minimal disease in non-Hodgkin's lymphoma (NHL) and Hodgkin's disease (HD) is reviewed. Relevant aspects of the basic biology of these diseases are introduced, including the interactions of NHL with bone marrow stromal cells and the consequences of suppressed apoptosis and induced chemoresistance which might explain why minimal lymphoma in bone marrow is a surrogate predictor of a poor clinical outcome. In contrast, NHL cells isolated from stroma, for example mobilized into blood by cytokine, may be more susceptible to apoptosis and clinically less significant. The possible role of angiogenesis in facilitating early metastasis to the bone marrow is considered. Methods of detecting minimal NHL are reviewed and differences in predictive reliability of tumor detected by culture methods versus molecular techniques which identify clonal bcl-2 or antigen receptor rearrangements are discussed. The role of detection of HD by analysis of unique rearrangements of the immunoglobulin heavy and light chain genes is discussed as is the possibility that Reed–Sternberg (RS) cells can be detected molecularly as well as grown in culture from blood and apheresis harvests of patients. It appears that patients with cells resembling RS cells in their harvest do less well following high dose therapy and transplantation and additional studies of this topic are warranted. Future developments including quantitative monitoring of disease burden by real-time automated PCR and the application of genetic profiling to identify genetic markers specific to the tumor and which, potentially can predict prognosis is suggested. Also, the problems which may arise in attempts to monitor the impact of newer therapies such as anti-lymphoma antibodies and vaccines which may preferentially deplete tumor cells from blood and marrow are considered. The past 10 years has witnessed dramatic progress in the application of techniques to monitor minimal lymphoma. This technology has helped demonstrate the success of some new therapeutic approaches e.g. antibody and vaccine therapies, and served to emphasize the failure of others, for example, stem cell selection to purge lymphoma from patient harvests. Technologically, the field is not yet mature and further evolution may be expected.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1006280924456
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  • 4
    Electronic Resource
    Electronic Resource
    Extrachromosomal human immunodeficiency virus type-1 DNA can initiate a spreading infection of HL-60 cells (1991)
    New York, N.Y. : Wiley-Blackwell
    Journal of Cellular Biochemistry 45 (1991), S. 366-373 
    Details
    ISSN: 0730-2312
    Keywords: HIV-1 infection of promyelocytes ; unintegrated HIV-1 DNA ; azidothymidine ; CD4 ; clonal analysis ; Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Chemistry and Pharmacology , Medicine
    Notes: In this report, we describe a human immunodeficiency virus type-1 (HIV-1)-infected promyelocytic cell line, OM, derived from HL-60 cells. Although the OM cell line was biologically cloned twice, the pattern of HIV-1 expression during culture appeared analogous to a classical acute spreading infection and was inhibited by both azidothymidine and recombinant soluble CD4 treatment. The number of OM cells actually expressing HIV-1 at the beginning of culture was 0%, reached a peak of nearly 100% at 6 weeks, and then fell to 〈 10% HIV-1+ cells by 10 weeks. Clonal analysis of the surviving cells verified that stable HIV-1+ OM cells resulted from the spreading infection. Southern analysis confirmed the transmission of HIV-1 through these OM cultures and the occurrence of stable clones which resulted. The initial percentage of OM cells actually harboring the HIV-1 genome was 〈0.1%, indicating nonfaithful transmission of an unintegrated HIV-1 genome during clonal expansion. These results demonstrate that extrachromosomal HIV-1 DNA can contribute to the spread of HIV-1 infection and give rise to cells which have stably integrated HIV-1 provirus.
    Additional Material: 5 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jcb.240450410
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    Paper (German National Licenses)
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