ISSN:
0952-3499
Keywords:
Chemistry
;
Biochemistry and Biotechnology
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Medicine
Notes:
The synthesis of an 11 membered ring bis-lactam, a system which is designed as a conformationally restricted mimetic of type I and II β-turns is described. Computer assisted molecular modeling was used to compare the predicted low energy conformers of the turn mimetic with idealized type I and type II turn structures. Initial computation analysis indicates that the basic ring structure will provide an excellent foundation for the development of variety of β-turn mimetics.
Additional Material:
2 Ill.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/jmr.300010205
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