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  • 1
    ISSN: 1365-2036
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Aim : To identify optimal antibiotics for second-line quadruple therapy of Helicobacter pylori after failed 1-week triple therapy.Methods : One hundred patients were enrolled in this study after the failure of 1-week triple therapy. They were randomized to receive 1-week quadruple therapy consisting of amoxicillin, omeprazole and bismuth salts, plus either metronidazole or tetracycline. Before quadruple therapy, the H. pylori culture of each patient was tested for metronidazole resistance or clarithromycin resistance by E-test. Six weeks later, an endoscopy or 13C-urea breath test was used to define the success of H. pylori eradication.Results : The H. pylori eradication rates by intention-to-treat and per protocol analysis were higher in the tetracycline group than in the metronidazole group (intention-to-treat: 78% vs. 58%, P 〈 0.05; per protocol: 89% vs. 67%, P 〈 0.05). In the metronidazole group, but not in the tetracycline group, the per protocol eradication rate of quadruple therapy was lower for the infected isolates with metronidazole resistance than for those without metronidazole resistance (77% vs. 33%, P 〈 0.05).Conclusion : Quadruple therapy, including tetracycline and amoxicillin, improves the H. pylori eradication rate after failed triple therapy.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Oxford UK : Blackwell Science Ltd
    Alimentary pharmacology & therapeutics 16 (2002), S. 0 
    ISSN: 1365-2036
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: To test the impact of intravenous omeprazole on Helicobacter pylori eradication for bleeding peptic ulcers.〈section xml:id="abs1-2"〉〈title type="main"〉Methods:A total of 175 H. pylori-infected patients with bleeding peptic ulcers were randomized into either an omeprazole group or a ranitidine group, receiving intravenous omeprazole or ranitidine for 3 days after endoscopy. Afterwards, 1-week triple therapy was used to eradicate H. pylori for both groups. Six weeks later, either a 13C-urea breath test or follow-up endoscopy was performed to assess the success of H. pylori eradication.〈section xml:id="abs1-3"〉〈title type="main"〉Results:The rebleeding rate was lower in the omeprazole group vs. the ranitidine group (6% vs. 17%, P 〈 0.05). The H. pylori eradication rate was higher in the omeprazole group (intention-to-treat analysis: 83% vs. 66%, P 〈 0.05; per protocol analysis: 93% vs. 80%, P 〈 0.05). For patients with duodenal ulcers, the per protocol H. pylori eradication rate of the omeprazole group was higher than that of the ranitidine group (93% vs. 73%, P 〈 0.05).〈section xml:id="abs1-4"〉〈title type="main"〉Conclusions:Intravenous omeprazole can decrease the risk of rebleeding of peptic ulcers. For duodenal ulcers, in particular, intravenous omeprazole may even improve the H. pylori eradication rate of the subsequent triple therapy.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    New York, NY [u.a.] : Wiley-Blackwell
    Biotechnology and Bioengineering 23 (1981), S. 1267-1287 
    ISSN: 0006-3592
    Keywords: Chemistry ; Biochemistry and Biotechnology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: This article and develops a process for large-scale production of glycerol by means of a hemophilic algae. The process is shown to be economically and technically feasible. Although the proposed process is extremely capital intensive, the total production cost is competitive with existing glycerol process. In addition, the overall energy requirement is much lower than that of the petrochemical process. This proposed process provides an alternative route for glycerol production that is minimally dependent on fossil fuels and is therefore, less sensitive to crude oil availability and price. The primary raw material carbon dioxide from stack gas, is an inexpensive and renewable resource. Maximal Utilization of solar energy is made not only in the glycerol synthesis steps but also in the product recovery system. Significant improvement in the process economics can be realized through further development of large-scale cultivation technology, and biomass distribution and collection machinery. Due to the labor intensive nature of the proposed algal process, it is particularly suitable for less developed nations with limited fossil fuel resources and lower labor costs.
    Additional Material: 8 Ill.
    Type of Medium: Electronic Resource
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