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  • 1
    Electronic Resource
    Electronic Resource
    Neuroregulation of protein synthesis in odontoblasts of the first molar of the rat after wounding (1987)
    Springer
    Cell & tissue research 248 (1987), S. 119-123 
    Details
    ISSN: 1432-0878
    Keywords: Odontoblasts ; Protein synthesis ; Denervation ; Neural regulation ; Wound healing ; Autoradiography ; Rat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Odontoblasts respond to occlusal trauma by increased elaboration of a matrix which is subsequently calcified to form reparative dentin. The purpose of the present study was to analyze quantitatively and compare the ability of odontoblasts to synthesize collagen after wounding in rats with an intact innervation (baseline) and in rats with sensory (inferior alveolar nerve, IAN) and/or sympathetic (superior cervical ganglion, SCG) surgical denervation. Surgery was performed 7 days prior to wounding. All rats had 1 mm of enamel and dentin removed from the occlusal surface of the first mandibular molar (resected side) with the contralateral tooth serving as a control. Rats were killed 1 h after injection with3H-proline on days 0, 5, 10 or 15 after wounding, and mandibles were removed and processed for autoradiography. Grain counts were performed over odontoblasts throughout the pulp horns for each time period and for control and experimental molars in intact (baseline) and denervated groups. When compared to the control baseline, the experimental baseline data showed increased3-proline uptake throughout the study with a peak at 5 days. When compared to the baseline data, IAN and SCG results demonstrated a delay or attenuation of the protein synthetic response. The results indicate that the sensory and sympathetic neural components may regulate odontoblastic response to wounding.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01239971
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  • 2
    Electronic Resource
    Electronic Resource
    Presence and location of adrenergic nerve endings in the dental pulps of mouse molars (1980)
    New York, NY [u.a.] : Wiley-Blackwell
    The @Anatomical Record 198 (1980), S. 59-71 
    Details
    ISSN: 0003-276X
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine
    Notes: In all, 30 adult (45-day-old) Swiss Webster mice were used for light and electron microscopic examination of the presence, number, and location of adrenergic endings in the first molar teeth. Prior to sacrifice, 10 animals received i.p. injections at 8, 6, 4, and 2 hours of 0.5 cc of 20 mg/kg solution of 5-hydroxydopamine (5-OH-DA) as a label for adrenergic endings. The animals were then anesthetized, perfused with Karnovsky's fixative, and the teeth were postfixed in Osmic acid, decalcified, embedded in methacrylate, and serial-sectioned. The sections were surveyed by light microscopy, and the number and location of nerve endings containing the reduced 5-OH-DA were recorded. Ten control mice were injected with the vehicle solution and prepared in the same manner. A third series of mice were given a single injection of 5-OH-DA, sacrificed, and prepared for ultrastructural study. The molar pulps were divided into four areas to facilitate examination: pulp horns, coronal pulp, bifurcation area, and root pulp. These four areas were further divided into three zones: odontogenic, vascular-related, and nonvascular-associated. The location and number of endings were evaluated, and an average of approximately 70 endings containing the 5-OH-DA were found in each tooth using light microscopy. These represented 35.5 ± 5.2 in the pulp horns; 26.1 ± 2.4 in the central coronal; 5.4 ± 0.7 in the bifurcation, and 5.6 ± 0.9 in the root pulp per tooth. Vascular related endings were found in greatest number, the odontogenic zone next, and free endings least. Verification of location of 5-OH-DA by ultrastructural analysis revealed the false transmitter in vesiculated endings in the four areas and zones of the pulp.
    Additional Material: 8 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/ar.1091980105
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  • 3
    Electronic Resource
    Electronic Resource
    Denervation-induced changes in cell proliferation in the rat molar after wounding (1986)
    New York, NY [u.a.] : Wiley-Blackwell
    The @Anatomical Record 214 (1986), S. 348-352 
    Details
    ISSN: 0003-276X
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine
    Notes: The dental pulp has the capacity to initiate and maintain repair after trauma. The purpose of the present study was to quantitatively analyze the role of the peripheral nervous system in regulation of pulpal cell proliferation in response to wounding. Six groups often rats were used in these studies. There was one baseline group (wounded, but innervation intact) and five resection groups. The resection groups included rats with unilateral superior cervical ganglionectomy (SCG), unilateral inferior alveolar nerve resection (IAN), unilateral chorda tympani (CT) resection, IAN + SCG, or a complete unilateral nerve resection (IAN + SCG + CT). One millimeter of enamel and dentin was removed from the first mandibular molar on the experimental (resected) side. Therefore, each rat had an experimental and control molar. Rats were killed at various intervals from day 0 to day 15 after wounding and received 0.5 μCi/g b.wt. 3H-thymidine 1 hour before death. For the baseline (innervation intact) data a peak in 3H-thymidine incorporation occurred at 5 days after wounding. In the resected groups, there was a general increase in the number of labeled cells at the zero time point, and a suppression of the 5-day peak with a delay in the proliferative response to wounding. The SCG + IAN-resected group maintained the lowest number of labeled cells throughout the entire experimental period compared to the experimental baseline data and the two controls. At the initial and termination points the SCG + IAN-resected groups demonstrated the highest number of labeled cells. The baseline data indicate that the maximal response to wounding occurs at day 5. Denervation results in a delay of the cell proliferative response to wounding with the most dramatic delay occurring in the IAN + SCG-resection group. The results indicate that the autonomic and sensory components of the peripheral nervous system may interact in regulating the proliferative response of pulpal cells to wounding.
    Additional Material: 1 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/ar.1092140403
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    Paper (German National Licenses)
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