ISSN:
1572-8773
Keywords:
cyclic voltammetry
;
DNA biosynthesis
;
hybrid antitumor compounds
;
quinone thiosemicarbazone
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
,
Chemistry and Pharmacology
Notes:
Abstract Coordinately unsaturated Cu(II) and Fe(III) complexes of the stoichiometry [Cu(L)Cl] and [Fe(L)Cl2], where L=tridentate anion of 2-hydroxy-1,4-naphthoquinone 1-thiosemicarbazone (2HNQTSC) and its 3-methyl derivative (3M2HNQTSC), were screenedin vitro against P388 lymphocytic leukemia cells. Copper complexes were found to be more effective inhibitors of DNA synthesis than analogous Fe(III) compounds. The inhibitory activities are suggested to be related to Cu(II)−Cu(I) redox couple or nitrogen adduct formation.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01062216
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