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  • 1
    ISSN: 1460-9592
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Background: The aim of this study was to verify if variations of thyroid hormones related to circumstances of delivery and mode of maternal anaesthesia can contribute to neonatal neutrophil respiratory burst and natural killer cell activity. Methods: We evaluated 10 infants born by vaginal delivery (group A), 10 infants born by caesarean section after epidural anaesthesia with lidocaine (group B) and 10 infants born by caesarean section after general anaesthesia with sevoflurane (group C). Results: A significant reduction of neutrophil respiratory burst test was found in groups A and C compared with group B. Natural killer cell (NK) activity with an effector : target ratio of 30 : 1 (NK30) and 10 : 1 (NK10) was significantly higher in group A compared with the B and C groups. In addition, thyroid stimulating hormone (TSH) concentration was significantly reduced in group A compared with the B and C groups. A significant negative correlation was found between TSH and NK30 or NK10. Conclusions: Our results suggest that the mode of delivery and anaesthesia can significantly modify the endocrine-immune system in the newborn. Caesarean section delivery with regional anaesthesia seems to produce fewer modifications of neonatal immune function compared with general anaesthesia.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    Biophysical Chemistry 38 (1990), S. 201-211 
    ISSN: 0301-4622
    Keywords: Circular dichroism ; Conformation ; DNA ; Dynamic light scattering ; Ethidium bromide ; Plasmid
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology , Physics
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    Biophysical Chemistry 45 (1992), S. 101-108 
    ISSN: 0301-4622
    Keywords: Curved DNA ; DNA conformation ; Dynamic light scattering ; Plasmid DNA
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology , Physics
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    Journal of Molecular Liquids 41 (1989), S. 327-345 
    ISSN: 0167-7322
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Chemistry and Pharmacology , Physics
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    Journal of Luminescence 40-41 (1988), S. 274-275 
    ISSN: 0022-2313
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Chemistry and Pharmacology , Physics
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Allergy 52 (1997), S. 0 
    ISSN: 1398-9995
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: We evaluated the immunogenicity and antigenicity of a formula based on partially hydrolyzed cow's milk whey protein in infants at risk of atopy and in controls. Total IgE and specific IgE, IgG, and IgG4 subclass antibodies against egg albumin and cow's milk α-lactalbumin, casein, and β-lactoglobulin were measured by radioimmunoassay of cord blood and of peripheral blood at 5 days and 6 months of life in five groups of infants: 16 breast-fed infants at risk of atopy (group 1), 21 partially hydrolyzed whey formula-fed infants at risk of atopy (group 2), 14 formula-fed infants at risk of atopy (group 3), 10 breast-fed control infants (group 4), and 13 formula-fed control infants (group 5). Total IgE concentration was significantly lower in group 2 at 6 months than in groups 3 and 5 infants and similar to that observed in groups 1 and 4 infants. The concentration of specific antiegg and anti-cow's milk protein IgG and of specific anti-cow's milk α-lactalbumin and β-lactoglobulin IgG4 subclass antibodies was significantly reduced in group 2 as compared to group 3 infants and similar to that found in breastfed infants. In conclusion, the partially hydrolyzed formula was less immunogenic and antigenic than a traditional formula and was as immunogenic and antigenic as breast milk.
    Type of Medium: Electronic Resource
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  • 7
    Electronic Resource
    Electronic Resource
    Springer
    Il nuovo cimento della Società Italiana di Fisica 11 (1989), S. 745-759 
    ISSN: 0392-6737
    Keywords: Interactions with radiations at the molecular level ; luminescence ; Scattering, diffraction, dispersion and polarization
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Description / Table of Contents: Riassunto È stato messo a punto un apparato per misure di light scattering dinamico (DLS), tecnica di grande utilità per lo studio della conformazione e della dinamica delle macromolecole. In questo lavoro si è studiato un DNA circolare, PACL29, di 5400 paia di basi, peso molecolare 3.27·106 daltons, e si sono separate due componenti esponenziali nella funzione di correlazione ricavando pertanto due coefficienti di diffusione. Il primo corrisponde al moto traslazionale (D=(2.9±0.3)·108cm2/s), mentre ai moti interni corrisponde un coefficiente di diffusioneD i=(11.7±0.3)·108cm2/s con un tempo di rilassamento interno τi=(850±200)μs.
    Abstract: Резюме Собрана и испытана аппаратура для динамического рассеяния света на растворах. Предложенная техника динамического рассеяния света удобна для исследования конформации и динамики макромолекул. В этой работе исследуется кольцевая ДНК, PACL 29, (молекулярный вес ≃ 3,27 106 Дальтон) и выделяются две компоненты коэффициента диффузии. Первая компонента, соответствующая трансляционной диффузии, даетD=(2.9±0.3)·108 см2/с, тогда как внутреннее движение соответствует коэффициенту диффузииD i=(11.7±0.3)·108 см2/с с временем внутренней релаксации τi=(850±200)μmkc.
    Notes: Summary An apparatus for dynamic light scattering (DLS) from solutions has been assembled and tested. The technique of DLS appears as a powerful help towards the understanding of the conformation and the dynamics of macromolecules. In the present work circular DNA, PACL29, of 5400 base pairs (molecular weight≃3.27·106 daltons), has been investigated and two components of the diffusion coefficient (D) have been separated. The first corresponding to translational diffusion givesD=(2.9±0.3)·108cm2/s whereas the internal motion corresponds to a diffusion coefficientD i=(11.7±0.3)·108cm2/s with an internal relaxation time τi=(850±200)μs.
    Type of Medium: Electronic Resource
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  • 8
    Electronic Resource
    Electronic Resource
    Springer
    European journal of clinical pharmacology 25 (1983), S. 507-509 
    ISSN: 1432-1041
    Keywords: cefoxitin ; newborn infants ; bacterial infection ; pharmacokinetics ; cephalosporin
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary Fifteen patients less than 2 months old with bacterial infections caused by pathogens known or presumed to be sensitive to cefoxitin were studied. Cefoxitin was administered as an i.v. bolus injection over 15 min, every 8 h for 6 to 12 days, to a total daily dosage of 90 mg/kg. In 14 patients cefoxitin therapy resulted in eradication of the pathogen and in recovery from clinical signs of infection. Only one patient did not respond to cefoxitin therapy. No adverse clinical or haematological effects definitely caused by cefoxitin were observed. Plasma and urine samples collected after the first dose were assayed for cefoxitin by HPLC. Pharmacokinetic data indicated larger apparent volume of distribution (0.51/kg), a smaller plasma clearance (0.271/h/kg) and a longer half-life (1.43 h) than in adults. The plasma half-life was inversely correlated (p〈0.05) to the postnatal age of the patients. Cefoxitin may be safely used in infants with infections caused by susceptible pathogens.
    Type of Medium: Electronic Resource
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  • 9
    Electronic Resource
    Electronic Resource
    Springer
    European journal of pediatrics 149 (1989), S. 94-95 
    ISSN: 1432-1076
    Keywords: Neonate ; Kidney length ; Ultrasound
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Kidney length was evaluated by ultrasound in 132 healthy neonates with gestational ages from 27 to 42 weeks and birth weights from 790 to 4200g. A highly significant correlation was found between the length of the kidneys and gestational age or birth weight.
    Type of Medium: Electronic Resource
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  • 10
    Electronic Resource
    Electronic Resource
    Springer
    European journal of pediatrics 150 (1991), S. 481-482 
    ISSN: 1432-1076
    Keywords: Newborn infant ; PMN chemotaxis ; Caesarean section delivery
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We evaluated polymorphonuclear leucocyte (PMN) chemotaxis and cortisol levels in cord blood from 15 healthy term infants delivered by caesarean section and from 15 healthy vaginally delivered term infants. Mean neutrophil chemotaxis was significantly higher in infants delivered by caesarean section (78.3±23.4μm) than in vaginally delivered infants (57.8±16.6 μm;P=0.01). Mean blood cortisol level was significantly lower in infants delivered by caesarean section (9.14±2.76 μg/dl) than in infants born by vaginal delivery (20.71±6.98 μg/dl;P=0.0001). No relationship was found between PMN chemotaxis and blood cortisol level. The higher neutrophil chemotactic activity observed in infants delivered by caesarean section could be related to general maternal anaesthesia.
    Type of Medium: Electronic Resource
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