ISSN:
1573-904X
Keywords:
mean residence time
;
pharmacokinetics
;
Michaelis–Menten elimination
;
one-compartment model
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
Notes:
Abstract An equation for the mean residence time (MRT) of drug in the body is derived for the system where drug is injected intravenously into a one-compartment model and eliminated by a single, capacity-limited process. This MRT is a complex function of dose, volume, V m, and K m but degenerates into the classical volume/clearance expression under limiting low-dose conditions (K m ≫ C 0). The equation was validated by comparison of the MRT obtained by direct calculation versus numerical area estimation for simulated data. The equation may be useful analytically in the estimation of the fundamental Michaelis–Menten parameters, V m and K m, from experimental data.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1023/A:1016486012446
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