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  • 1
    Electronic Resource
    Electronic Resource
    Protein composition of forebrain myelin isolated from triethyllead-intoxicated young rats (1978)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of neurochemistry 30 (1978), S. 0 
    Details
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1471-4159.1978.tb10801.x
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  • 2
    Electronic Resource
    Electronic Resource
    THE EFFECT OF TRIETHYLLEAD ON TOTAL AND MYELIN PROTEIN SYNTHESIS IN RAT FOREBRAIN SLICES (1979)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of neurochemistry 32 (1979), S. 0 
    Details
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Rats (20-day-old) were acutely intoxicated with triethyllead and their forebrains were studied during the following 14 days. All the lead in the tissue was found in the form of triethyllead, proving that the toxin per se was responsible for the pathological changes observed in the organ. The incorporation of [14C]leucine into the acid-insoluble protein was suppressed in the forebrain slices prepared from the intoxicated animals as well as in the slices, to which PbEt3 was added in vitro. In both systems the synthesis of myelin protein was inhibited more than the total protein synthesis. The results suggest a specificity of triethyllead toward processes involved in the furnishing of the myelin membrane proteins.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1471-4159.1979.tb04526.x
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  • 3
    Electronic Resource
    Electronic Resource
    PHOSPHOLIPID AND GLYCOLIPID PATTERNS OF INFANT AND FOETAL BRAIN THIN-LAYER CHROMATOGRAPHIC STUDIES (1965)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of neurochemistry 12 (1965), S. 0 
    Details
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1471-4159.1965.tb04252.x
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  • 4
    Electronic Resource
    Electronic Resource
    PHOSPHOLIPIDS AND GLYCOLIPIDS OF TUMOURS IN THE CENTRAL NERVOUS SYSTEM (1965)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of neurochemistry 12 (1965), S. 0 
    Details
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1471-4159.1965.tb04255.x
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  • 5
    Electronic Resource
    Electronic Resource
    Suppressive Effect of Triethyllead on Entry of Proteins into the CNS Myelin Sheath In Vitro (1980)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of neurochemistry 35 (1980), S. 0 
    Details
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Incorporation of [14C]leucine into the myelin sheath was studied in brain stem slices prepared from 22-day-old rats. Individual major myelin proteins were separated by polyacrylamide gel electrophoresis in the presence of sodium dodecyl sulphate. There was a time lag before incorporation of the label into proteolipid protein (PLP) and intermediate protein (IP) reached maximal rates. Labelling of basic proteins (BP) and Wolfgram proteins (WP) revealed a much shorter lag in entry. Appearance of radioactive proteins in the myelin sheath was significantly hampered by triethyllead (PbEt3) added to the incubation medium at micromolar concentrations. Inhibition values were highest in the case of PLP and were closely followed by the values for IP. BP and WP were less inhibited, although incorporation of these proteins into myelin was still suppressed more than was synthesis of total homogenate protein. Thus, myelin-forming cells seem to be unduly vulnerable to the toxin relative to the rest of the tissue. Furthermore, the results indicate an interference of PbEt3 with certain posttranslational processes involved in furnishing of integral myelin proteins.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1471-4159.1980.tb06275.x
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  • 6
    Electronic Resource
    Electronic Resource
    Variability of Sleep Measures in Normal Subjects (1974)
    Oxford, UK : Blackwell Publishing Ltd
    Psychophysiology 11 (1974), S. 0 
    Details
    ISSN: 1469-8986
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine , Psychology
    Notes: Variability of sleep measures during 4 nights was examined in 10 normal young adults. The variables analyzed included: Sleep Stage Percentages; Sleep Time; Latency, Duration, and Cycle Time of REM; No. of REM Periods; and No. of Eye Movements (EM). No indication of First Night Effect was found, except that EM showed significant increases across nights. Although group means corresponded to conventional norms, considerable inter- and intraindividual variability was apparent, with Stage 2 and REM yielding lowest Variability Coefficients. Between nights, consistent positive correlations were found for Awake, REM, REM Latency, and particularly for Stage 4 and EM. Consistency of the relationship between nights for the sleep stages was not generally improved by equating sleep time either within or between Ss. Few intercorrelations between variables were significant. Within nights the first REM Duration was the shortest and the first Non-REM Duration the longest, while neither REM nor Non-REM Cycle Time changed significantly. In 25% of the records, Stage 3 terminated before Stage 4. Variability was discussed in terms of procedural aspects, trait characteristics, and situational factors.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1469-8986.1974.tb00580.x
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  • 7
    Electronic Resource
    Electronic Resource
    Autonomic Specificity and Stereotypy Revisited (1978)
    Oxford, UK : Blackwell Publishing Ltd
    Psychophysiology 15 (1978), S. 0 
    Details
    ISSN: 1469-8986
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine , Psychology
    Notes: Stimulus-response specificity and individual-response stereotypy were evaluated during segments of anticipation, stimulation, and recovery. Skin conductance, heart period, respiration period, and blood pressure were measured in 20 normal subjects in response to six stimuli: Sound, Music, Math, Poem, Light, and Cold Pressor. The difference between mean level during each segment and prestimulation, corrected for prestimulus level, was divided by the nonsyste-matic variability of response in order to provide a standard score. Specificity was assessed through the Variable × Stimulus interactions of an analysis of variance and a components of variance analysis, and from a between subject concordance analysis. Stereotypy was inferred from the Variable × Subject interaction of the components analysis and from a between stimuli concordance analysis. Components of variance analyses were also obtained with scores covaried for anticipation level, with a previous method of score standardization, and with stimuli divided into two sets on the basis of response magnitude. Contributions to variance of specificity and stereotypy were shown to vary with method of standardization and type of stimulation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1469-8986.1978.tb01336.x
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  • 8
    Electronic Resource
    Electronic Resource
    Immunogenetic Studies of Respiratory Anaphylaxis in Selectively Bred Guinea Pigs (1985)
    Oxford, UK : Blackwell Publishing Ltd
    Allergy 40 (1985), S. 0 
    Details
    ISSN: 1398-9995
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The genetic and immunological basis of respiratory anaphylaxis was studied in two strains of guinea pigs selectively bred for either high or low respiratory anaphylactic response to inhalation of ovalbumin. Individuals of the parental strains, Fl-hybrids and backcross offspring were examined for class II MHC type and asthmatic response to ovalbumin. Analysis of the results revealed an association of asthma phenotype and MHC class II type. Apart from the gene(s) in the MHC several other genes seem to be involved in the control of guinea pig asthma.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1398-9995.1985.tb04149.x
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  • 9
    Electronic Resource
    Electronic Resource
    Mercury Frit Electrode, a New Indicator Electrode for Peak Voltammetry. (1966)
    s.l. : American Chemical Society
    Analytical chemistry 38 (1966), S. 1398-1400 
    Details
    ISSN: 1520-6882
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/ac60242a001
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  • 10
    Electronic Resource
    Electronic Resource
    Human Leucocyte Migration Inhibition (1976)
    Oxford, UK : Blackwell Publishing Ltd
    Scandinavian journal of immunology 5 (1976), S. 0 
    Details
    ISSN: 1365-3083
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Abstract. Within the last decade a variety of techniques have been developed and used for the detection of cell-mediated immunity in man by means of leucocyte migration inhibition in vitro. A detailed description of the leucocyte migration capillary tube technique (LMCT) and the leucocyte migration agarose technique (LMAT) is given. The procedure for selecting and using the proper antigen concentration is described. A description is also given of the indirect LMAT and the technique for determination of concanavalin A-induced lymphocyte release of leucocyte migration inhibition factor. Applications of these techniques are mainly intended for the exploration of the immunobiology of lymphocytes and cellular interactions associated with the immune response and the investigation of clinical conditions in man, i.e. infectious diseases, autoimmune diseases, transplantation states, tumour diseases, contact hypersensitivity and immunological deficiency states. Selection and adaptation to suit the experimental aim is necessary to obtain optimal results with these techniques. Their usefulness may be increased through more extensive use of purified antigens and indirect assays.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-3083.1976.tb03867.x
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