ISSN:
1432-1912
Keywords:
d-Fenfluramine
;
Anorectics
;
Rats
;
Mice
;
Guinea pigs
;
Serotonin
;
Serotonin receptors
;
Serotonin uptake
;
Serotonin release
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary The present study compares the anorectic activity of d-fenfluramine and its metabolite d-norfenfluramine in three animal species. d-Fenfluramine and d-norfenfluramine show anorectic activity at increasing doses (ED50) in rats, guinea pigs, and mice, d-norfenfluramine being more active than d-fenfluramine in all three species. Equiactive anorectic activities are reached with different brain levels of d-fenfluramine and d-norfenfluramine, guinea pigs being the most sensitive species, followed by rats then mice. The metabolite most probably plays a major role in the anorectic effect of d-fenfluramine in guinea pigs, contributes to the anorectic activity in rats, but adds little to the action of the parent drug in mice. The different sensitivity to d-fenfluramine and d-norfenfluramine in these three species does not appear to be explained by a number of biochemical parameters, including serotonin uptake or release, receptor subtypes, or 3H-d-fenfluramine binding and uptake.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00169550
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