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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    European journal of clinical pharmacology 40 (1991), S. 279-282 
    ISSN: 1432-1041
    Keywords: Caffeine ; Exercise ; Pharmacokinetics ; heavy coffe intake
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The effect of moderate exercise on the kinetics of caffeine in 12 healthy volunteers-6 heavy coffee drinkers (HD) and 6 light coffee drinkers (LD) has been studied. Kinetics at Rest was measured first (R): the subjects remained at rest for 8 h after a single 250 mg dose of caffeine. One week later, the Exercise Kinetics (E) was measured under the same conditions, but with the subjects performing moderate exercise (30% of VO 2 max) during the first hour of the study. Exercise raised the maximal plasma caffeine concentrations (R: 7.28; E: 10.45) and reduced both the half-life (R 3.99 h; E 2.29 h) and the volume of distribution (R 371; E 20.91). Both during exercise and at rest, HD had a greater half-life elimination and volume of distribution than LD. The results suggest potentiation of the effects of caffeine during exercise and an increase in its distribution due to regular heavy coffee intake.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1439-6327
    Keywords: Ventilatory equivalent of O2 and CO2 ; Blood lactate accumulation ; Young athletes ; Graded exercise testing
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The time course of changes in blood lactate concentration and ventilatory gas exchange was studied during an incremental exercise test on a cycle ergometer to determine if the lactate accumulation threshold (LT2) could be accurately estimated by the use of respiratory indices (VT2) in young athletes. LT2 was defined as the starting point of accelerated lactate accumulation. VT2 was identified by the second exponential increase in $$\dot V$$ E and the ventilatory equivalent for O2 uptake with a concomitant nonlinear increase in the ventilatory equivalent for CO2 output. Twelve trained subjects, aged 18–22 years, participated in this study. The initial power setting was 30 W for 3 min with successive increases of 30 W every minute except at the end of the test when the increase was reduced. Ventilatory flow ( $$\dot V$$ E), oxygen uptake ( $$\dot V$$ O2), carbon dioxide output ( $$\dot V$$ CO2), and ventilatory equivalents of O2 and CO2 were determined during the last 30 s of every minute. Venous blood samples were drawn at the end of each stage of effort and analysed enzymatically for lactate concentration. After each test, LT2 and VT2 were determined visually by two investigators from the graphic results using a double-blind procedure. The results [mean (SEM)] indicate no significant difference between LT2 and VT2 expressed as $$\dot V$$ O2 [43.98 (1.70) vs 44.93 (2.39) ml - min− - kg−], lactataemia [4.01 (0.28) vs 4.44 (0.37) mM - 1−], or heart rate [171 (3.36) vs 173 (3.11) min−]. In addition, strong correlations were noted between the two methods for $$\dot V$$ O2 (r=0.90,P〈0.001), lactataemia (r=0.75,P〈0.01), and heart rate (r=0.96,P〈0.001). It is concluded that VT2 coincides with LT2 determination and that the ventilatory gas exchange method can thus satisfactorily evaluate the lactate accumulation threshold in young athletes.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    European journal of applied physiology 64 (1992), S. 377-380 
    ISSN: 1439-6327
    Keywords: Caffeine ; Specific training ; Anaerobic performance ; Swimming velocity ; Lactate
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The influence of specific training on benefits from caffeine (Caf) ingestion was examined during a sprint test in a group of highly trained swimmers (T) and compared with the response of a group of untrained occasional swimmers (UT). Seven T and seven UT subjects swam freestyle two randomly assigned 2 × 100 m distances, at maximal speed and separated by 20 min of passive recovery, once after Caf (250 mg) and once after placebo (Pla) ingestion. Anaerobic capacity was assessed by the mean velocity (meters per second) during each 100 m and blood was sampled from the fingertip just before and 1, 3, 5, 7, and 9 min after each 100 m for resting and maximal blood lactate concentration ([1a−]b, max) determination. The [[1a−]b, max was significantly enhanced by Caf in both T and UT subjects (P〈0.01). However, only T subjects exhibited significant improvement in their swimming velocity (P〈0.01) after Caf or any significant impairment during the second 100 m. In light of these results, it appears that specific training is necessary to benefit from the metabolic adaptations induced by Caf during supramaximal exercise requiring a high anaerobic capacity.
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Springer
    European journal of applied physiology 65 (1992), S. 311-315 
    ISSN: 1439-6327
    Keywords: Lactataemia ; Lactate thresholds ; Maximal muscle exercise ; Aging ; Training
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary To study the effects of age and training on lactate production in older trained subjects, the lactate kinetics of highly trained cyclists [HT,n = 7; 65 (SEM 1.2) years] and control subjects with low training (LT,n = 7) and of similar age were compared to those of young athletes [YA,n = 7; 26 (SEM 0.7) years], during an incremental exercise test to maximum power. The results showed that the lactacidaemia at maximal oxygen uptake ( $$\dot VO_{2 max} $$ ) was lower for HT than for LT (P〈0.05) and, in both cases, lower than that of YA (P〈0.001). The respective values were HT: 3.9 (SEM 0.51), LT: 5.36 (SEM 1.12), and YA: 10.3 (SEM 0.63) mmol·1−1. At submaximal powers, however, the difference in lactacidaemia was not significant between HT and YA, although the values for lactacidaemia at $$\dot VO_{2 max} $$ calculated per watt and per watt normalized by body mass were significantly lower for HT (P〈0.001) and LT (P〈 0.02). These results would indicate that the decline in power with age induced a decline in lactacidaemia. Yet this loss in power was not the only causative factor; indeed, our results indicated a complementary metabolic influence. In the older subjects training decreased significantly the lactacidaemia for the same submaximal power (P〈0.01) and from 60% of $$\dot VO_{2 max} $$ onwards (P〈0.05); as for YA it postponed the increase and accumulation of lactates. The lactate increase threshold (Th1a−,1) was found at 46% $$\dot VO_{2 max} $$ for LT and at 56% $$\dot VO_{2 max} $$ for HT. The lactate accumulation threshold (Th1a−,2) was observed at approximately 80% $$\dot VO_{2 max} $$ for all three groups but at a value significantly different in each group. At Th1a−,2 the lactate value of HT was 2 (SEM 0.19) mmol · 1−1 thus closer to the value normally associated with the increase threshold instead of the accumulation threshold. In conclusion, the reduction in lactacidaemia was enhanced by training. Furthermore, the modification in the lactate kinetics with aging indicated that training at an intensity corresponding to a lactacidaemia of 2 and 4 mmol·1−1 was inadequate for master endurance athletes.
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Springer
    European journal of applied physiology 65 (1992), S. 188-191 
    ISSN: 1439-6327
    Keywords: Force-velocity exercise test ; Maximal anaerobic power ; Caffeine ; Lactate
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The aim of this study was to specify the effects of caffeine on maximal anaerobic power (W max). A group of 14 subjects ingested caffeine (250 mg) or placebo in random double-blind order. TheW max was determined using a force-velocity exercise test. In addition, we measured blood lactate concentration for each load at the end of pedalling and after 5 min of recovery. We observed that caffeine increasedW max [964 (SEM 65.77) W with caffeine vs 903.7 (SEM 52.62) W with placebo;P〈0.02] and blood lactate concentration both at the end of pedalling [8.36 (SEM 0.95) mmol · l−1 with caffeine vs 7.17 (SEM 0.53) mmol · l−1 with placebo;P〈0.011 and after 5 min of recovery [10.23 (SEM 0.97) mmol · l−1 with caffeine vs 8.35 (SEM 0.66) mmol · l−1 with placebo;P〈0.04]. The quotient lactate concentration/power (mmol · l−1 · W−1) also increased with caffeine at the end of pedalling [7.6 · 10−3 (SEM 3.82 · 10−5) vs 6.85 · 10−3 (SEM 3.01 · 10−5);P〈0.01] and after 5 min of recovery [9.82·10−3 (SEM 4.28 · 10−5) vs 8.84 · 10−3 (SEM 3.58 · 10−5);P〈0.02]. We concluded that caffeine increased bothW max and blood lactate concentration.
    Type of Medium: Electronic Resource
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