ISSN:
1546-1718
Source:
Nature Archives 1869 - 2009
Topics:
Biology
,
Medicine
Notes:
[Auszug] von Hippel–Lindau (VHL) gene inactivation occurs in von Hippel–Lindau (VHL) disease. The protein pVHL functions in a multi-subunit E3 ubiquitin ligase that targets the hypoxia-inducible transcription factor Hif1α for proteasomal degradation during normoxia. We establish that pVHL ...
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1038/ng1254
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