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  • 1
    Digitale Medien
    Digitale Medien
    Clinically equivocal melanocytic skin lesions with features of regression: a dermoscopic–pathological study (2004)
    Oxford, UK : Blackwell Science Ltd
    British journal of dermatology 150 (2004), S. 0 
    Details
    ISSN: 1365-2133
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Notizen: Background  Benign melanocytic skin lesions may be difficult to differentiate from melanoma both clinically and dermoscopically. One of the most confounding dermoscopic features, commonly seen in melanoma but in our experience also in melanocytic naevi, is represented by the so-called blue–white structures (BWS).Objectives  To evaluate diagnostic significance and histopathological correlates of BWS seen by dermoscopy in a series of clinically equivocal melanocytic skin lesions that were excised.Methods  Patients were recruited from six specialized pigmented lesion clinics in Austria, Italy and Spain over a period of 9 months. All consecutive patients showing one or more melanocytic lesions with BWS, but not classified as melanoma dermoscopically, were included. Each lesion was photographed clinically and dermoscopically. All images were reviewed by one of us and the degree, type and location of BWS evaluated for each lesion. A panel of four experienced dermatopathologists independently reviewed all specimens for diagnosis and one of them evaluated presence and degree of melanosis and/or fibrosis. The main outcome measures were the percentage and histopathological correlates of lesions with different degree, type and location of BWS.Results  All included lesions with BWS (n = 158) showed partial or focal regression histopathologically. One hundred and thirty-five (85·4%) lesions were diagnosed as melanocytic naevi (complete histopathological interobserver agreement), whereas 23 (14·6%) were defined as equivocal because at least one of four pathologists diagnosed the given lesion as melanoma. Only one lesion was diagnosed as melanoma by all four pathologists. The majority of naevi exhibited blue areas (84·4%) with a central distribution (57%) and involving 〈 50% of the lesion surface (89·6%). By contrast, 78·3% of equivocal lesions revealed a combination of white and blue areas with an irregular distribution (60·9%) and involving 〉 50% of the lesion surface (47·8%).Conclusions  Using degree and type of BWS, an algorithm was constructed that can be applied for the management of lesions exhibiting dermoscopic features of regression.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1111/j.1365-2133.2004.05657.x
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  • 2
    Digitale Medien
    Digitale Medien
    Circulating CD8+ lymphocytes, white blood cells, and survival in patients with mycosis fungoides (2005)
    Oxford, UK : Blackwell Science Ltd
    British journal of dermatology 153 (2005), S. 0 
    Details
    ISSN: 1365-2133
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Notizen: Background  There is a need for reliable, easily measurable laboratory markers that may help dermatologists to predict the course of mycosis fungoides (MF) when they first evaluate their patients.Objectives  Our objective was to identify clinical, haematological or immunological parameters as predictors of mortality in patients with MF.Methods  We conducted a retrospective study on a prevalent cohort of 124 patients with MF hospitalized at IDI-IRCCS, Rome, Italy, from 1983 to 2001. We calculated the proportion of patients surviving (Kaplan–Meier product–limit estimates) 5 and 10 years after first hospital admission, and hazard ratios (HR) from the Cox proportional hazards model.Results  Patients' survival was linked to age and staging (lower survival in older patients and in patients with staging IIB–IV). Higher numbers of white blood cells (WBC) and neutrophils, lower numbers of CD8+ lymphocytes, low haematocrit and lower levels of albumin were significantly associated with a lower survival probability. When simultaneously accounting for age and staging, CD8+ [HR = 3·02, 95% confidence interval (CI) 1·01–9·07 for CD8+ 〈 250 vs. ≥ 600 cells µL−1] and WBC (HR = 2·59, 95% CI 0·96–6·96 for WBC ≥ 9000 vs. 〈 6000 cells µL−1) were associated with survival. In addition, we observed an exceedingly high risk of death (HR = 12·40, 95% CI 3·11–49·43) for patients with a combination of WBC ≥ 9000 and CD8+ 〈 600 cells µL−1 vs. WBC 〈 9000 and CD8+ ≥ 600 cells µL−1).Conclusions  The measurement of CD8+ cells and WBC in MF seems to be a promising criterion to predict survival, and possibly to support treatment decisions and inclusion of patients in randomized controlled trials.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1111/j.1365-2133.2005.06755.x
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  • 3
    Digitale Medien
    Digitale Medien
    Characterization of the ultraviolet B and X-ray response of primary cultured epidermal cells from patients with disseminated superficial actinic porokeratosis (2004)
    Oxford, UK : Blackwell Science Ltd
    British journal of dermatology 150 (2004), S. 0 
    Details
    ISSN: 1365-2133
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Notizen: Background  Disseminated superficial actinic porokeratosis (DSAP) is the most common porokeratosis and is characterized by multiple keratotic lesions which tend to occur at sun-exposed sites. A mild hypersensitivity to X-rays has been reported for DSAP-derived fibroblasts and frequent over-expression of p53 has been found in lesional epidermis.Objectives  In order to clarify whether genome maintenance mechanisms might be compromised in this disease the following approaches were undertaken: (i) primary cultured keratinocytes and fibroblasts from DSAP patients were characterized for ultraviolet (UV) B and X-ray response; (ii) 15 lesions were studied for p53 mutations, and (iii) the differentiation status of DSAP-derived keratinocytes was evaluated.Methods  Primary cultures of keratinocytes and fibroblasts were established from lesional and nonlesional skin biopsies of two subjects with DSAP. p53 mutations were analysed by DNA sequencing of the conserved region of the TP53 gene. Differentiation was evaluated both in stratified epithelial sheets from confluent keratinocyte cultures and in organotypic skin cultures.Results  The cytotoxic and apoptotic response to UVB or X-irradiation was similar in DSAP-derived keratinocytes and fibroblasts when compared with normal cells. Two of 15 lesions examined presented p53 mutations located at nondipyrimidine sites. A strikingly decreased expression of filaggrin was observed both in reconstructed epidermis and in reconstructed skin.Conclusions  The UVB and X-ray response of DSAP-derived keratinocytes and fibroblasts indicates that the actinic character of this skin pathology is not due to radiation hypersensitivity. In agreement with this finding, mutations in the p53 gene, which are often associated with UV-related skin carcinogenesis, were rarely detected in DSAP lesions and were not UV-specific. Reconstructed epidermis and reconstructed skin models successfully reproduced the main features of this genodermatosis, showing that DSAP-derived keratinocytes bear an inherent defect in the terminal differentiation programme.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1111/j.1365-2133.2004.05714.x
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  • 4
    Digitale Medien
    Digitale Medien
    Slow spontaneous signals from brain tissue culture (1970)
    Springer
    Cellular and molecular life sciences 26 (1970), S. 13-16 
    Details
    ISSN: 1420-9071
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Medizin
    Notizen: Resumen La exploratión con microelectrodos, de explantes telencefálicos de embrión de pollo, registra espontáneamente señales de dos tipos: lentas y rápidas, confirmando hallazgos similares previamente reportados con macroelectrodos. Observandose un patron en la distributión de las señales lentas, las cuales son originadas por la misma fuente en cada explante pudiendo ser esta, las células de glía o el producto de potensiales dendríticos.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF01900360
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  • 5
    Digitale Medien
    Digitale Medien
    Immunohistochemical visualization of afferent nerve terminals in human globus pallidus and its alteration in neostriatal neurodegenerative disorders (1989)
    Springer
    Acta neuropathologica 78 (1989), S. 543-550 
    Details
    ISSN: 1432-0533
    Schlagwort(e): Globus pallidus ; Immunohistochemistry ; Calcineurin ; Synaptophysin ; Neuropeptides
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary The afferent nerve terminal in the human globus pallidus, which receives the projection nerve fibers from both the striatum and the subthalamic nucleus, were clearly visualized immunohistochemically using antibodies to calcineurin, synaptophysin, Met-enkephalin (MEnk) and substance P (SP). In normal control case, MEnk and SP-like immunoreactivities were densely localized in the external and internal pallidal segments, respectively, whereas calcineurin and synaptophysin were distributed throughout the globus pallidus. Calcineurin, synaptophysin, MEnk and SP-like immunoreactive peroxidase products decorated most of the long radiating dendrites and the cell bodies of the pallidal neurons. In the cases with Huntington's disease (HD) and striatonigral degeneration (SND), marked loss of calcineurin, MEnk and SP-like immunoreactivities was seen in the globus pallidus corresponding to areas of striatal neurodegeneration, whereas synaptophysin immunoreactivity remained in areas which revealed almost complete loss of calcineurin, MEnk and SP-like immunoreactivities. Calcineurin, MEnk and SP, which show difference in their localization patterns, may provide reliable markers for the striatal efferent nerve terminals, and synaptophysin for the entire pallidal afferent nerve terminals. This report demonstrates the distribution patterns of these neurochemical molecules in the globus pallidus with HD and SND.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00687717
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  • 6
    Digitale Medien
    Digitale Medien
    Calcineurin immunoreactivity in striatonigral degeneration (1989)
    Springer
    Acta neuropathologica 78 (1989), S. 65-71 
    Details
    ISSN: 1432-0533
    Schlagwort(e): Striatonigral degeneration ; Basal ganglia ; Calcineurin ; Immunohistochemistry
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary The basal ganglia (including substantia nigra) of two patients with striatonigral degeneration, who had clinical histories of Parkinson's disease, were studied immunohistochemically using a purified antibody to calcineurin (CaN). Marked loss of CaN-immunoreactive neurons in the putamen and neuromelanin-pigmented neurons in the zona compacta of the substantia nigra was seen in both cases. A small number of CaN-immunoreactive neurons remained dispersed in “clusters” or “islands” in the medial portion of the putamen. In one case there was loss of CaN-immunoreactive neurons in the caudate nucleus to a lesser degree than that in the putamen. In addition, both cases showed marked depletion of CaN-immunoreactive afferent nerve fibers in the external and internal segments of the globus pallidus and the zona reticulata of the substantia nigra. This report emphasizes the usefulness of the CaN-immunostaining technique for assessing the striatal efferents in human basal ganglia, and shows the neuropathological changes in the basal ganglia with striatonigral degeneration which were not possible to ascertain with previous techniques.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00687404
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  • 7
    Digitale Medien
    Digitale Medien
    Distribution of epithelial membrane antigen in normal and neoplastic human ependyma (1989)
    Springer
    Acta neuropathologica 78 (1989), S. 325-328 
    Details
    ISSN: 1432-0533
    Schlagwort(e): Ependyma ; Ependymoma ; Epithelial membrane antigen ; Immunohistochemistry
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary The ependyma and choroid plexus of 23 normal brains and 20 ependymal tumors were examined immunohistochemically for expression of epithelial membrane antigen (EMA) using a specific monoclonal antibody. The ependyma of normal brains showed three patterns of immunoreactivity: membrane immunoreactivity confined to the luminal surface; irregular punctate intracytoplasmic immunore-activity in the subependymal layer; and spherical and ring-like intracytoplasmic immunoreactivity in the subependymal layer. Of 13 differentiated ependymomas 11 reflected the immunoreactive patterns of normal ependyma. The anaplastic ependymomas and ependymoblastomas had no immunoreactivity. Our results indicate that EMA has a highly selective distribution in the ependyma, and is a marker for differentiated ependymoma.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00687763
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  • 8
    Digitale Medien
    Digitale Medien
    Focal accumulation of phosphorylated neurofilaments within anterior horn cell in familial amyotrophic lateral sclerosis (1989)
    Springer
    Acta neuropathologica 79 (1989), S. 37-43 
    Details
    ISSN: 1432-0533
    Schlagwort(e): Amyotrophic lateral sclerosis ; Phosphorylated neurofilament ; Immunohistochemistry ; Lewy body-like inclusion ; Cord-like neurite thickening
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary Distribution of phosphorylated neurofilament proteins within anterior horn cells in three cases of familial and six cases of sporadic amyotrophic lateral sclerosis (ALS) and ten control cases were investigated by using a monoclonal antibody. Two distinct staining patterns of perikarya were observed; (1) homogeneous pattern; either the entire or a part of the perikaryon was immunostained homogeneously (homogeneously diffuse or partial pattern); (2) focal pattern: perikarya contained very distinct, inclusion-like focal accumulation of immunoreactive products of various morphologies such as round, ring-shaped, cord-like, tube-like and more irregular shapes. The homogeneous pattern was found in all three groups but was most common in sporadic ALS. On the other hand, the focal pattern was seen almost exclusively in familial ALS. The focal accumulation of neurofilaments appears at least in part to be related to the Lewy body-like hyaline inclusion which is known to contain neurofilaments. In addition, cord-like swellings of neurites in familial ALS also showed focal neurofilament accumulation. These observations suggest that the focal accumulation of phosphorylated neurofilaments is characteristic of familial ALS, although it may not be specific to the entity. The pathological process(es) producing the neurofilamentous abnormality may play an important role in anterior horn cell degeneration in familial ALS.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00308955
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  • 9
    Digitale Medien
    Digitale Medien
    Microelectrode studies of spontaneous potentials from chick embryo telencephalon in vitro (1966)
    Springer
    Cellular and molecular life sciences 22 (1966), S. 439-441 
    Details
    ISSN: 1420-9071
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Medizin
    Notizen: Résumé A l'aide de micro-électrodes, des potentiels rythmiques spontanés ont été enregistrés dans du tissu télencéphalique d'embryons de poulets âgès de 14 jours, in vitro. Ces potentiels sont semblables à ceux précédemment décrits en utilisant des électrodes de 80μ en platine. La possibilité pour ces potentiels d'être produits par les neurones de l'explant est discuté.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF01900969
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  • 10
    Digitale Medien
    Digitale Medien
    Epithelial cysts in the central nervous system, characteristic expression of cytokeratins in an immunohistochemical study (1990)
    Springer
    Acta neurochirurgica 107 (1990), S. 93-101 
    Details
    ISSN: 0942-0940
    Schlagwort(e): Central nervous system ; cytokeratins ; epithelial cyst ; immunohistochemistry
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary Nineteen epithelial cysts in the central nervous system including six colloid cysts of the third ventricle, seven Rathke's cleft cysts in the sella, two enterogenous cysts in the posterior fossa, two epithelial cysts in the spinal canal and two neuroectodermal cysts in the cerebrum were examined immunohistochemically for expression of intermediate filament proteins-simple type, stratified type and skin type cytokeratins and GFAP. Colloid cysts of the third ventricle, Rathke's cleft cysts in the sella and epithelial cysts in the spinal canal expressed complex type cytokeratins while enterogenous cysts and neuro-ectodermal cysts showed only simple type cytokeratins. In addition, Rathke's cleft cysts expressed GFAP in occasional lining cells. The characteristic composition and distribution of cytokeratins in various kinds of epithelial cysts in the central nervous system are demonstrated and discussed with regard to their origins.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF01405786
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