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  • 1
    Electronic Resource
    Electronic Resource
    Action Potentials in the Cerebral Cortex (1952)
    [s.l.] : Nature Publishing Group
    Nature 169 (1952), S. 240-241 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] As well as occurring spontaneously, these action potentials have been found in the primary visual cortex in response to electrical stimulation of the contralateral retina, when they sometimes occur in high-frequency bursts. Both negative and positive potentials have been observed, though the former ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/169240b0
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  • 2
    Electronic Resource
    Electronic Resource
    A Specific Response in the Hippocampus of the Rabbit to Olfactory Stimulation (1959)
    [s.l.] : Nature Publishing Group
    Nature 184 (1959), S. 1697-1699 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] THE olfactory bulb projects to the pir if orm lobe through the lateral tract and through the more medial radiation which is continuous with the anterior limb of the anterior commissure. The distribution of these tracts within the piriform lobe has been described in experimental material stained by ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/1841697a0
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  • 3
    Electronic Resource
    Electronic Resource
    A Heat-Loss Mechanism involving the Habenular, Interpeduncular and Dorsal Tegmental Nuclei (1959)
    [s.l.] : Nature Publishing Group
    Nature 184 (1959), S. 1724-1724 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] In rabbits anaesthetized with urethane, ether or pentobarbital electrical stimulation in a wide region between the optic chiasma and the anterior commissure can be shown to induce both panting and an inhibition of somatic reflexes such as the knee jerk. If stimulation at 25-50 pulses per sec. is ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/1841724a0
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  • 4
    Electronic Resource
    Electronic Resource
    Blood-brain barrier dysfunction in thiamine-deficient, alcohol-treated rats (1984)
    Springer
    Acta neuropathologica 62 (1984), S. 235-241 
    Details
    ISSN: 1432-0533
    Keywords: Thiamine deficiency ; Alcohol ; Brain pathology ; Blood-brain barrier ; Rats
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Rats maintained on a thiamine-deficient diet for 38 days lost weight and showed neurological symptoms. The PA value, representing the permeability of the blood-brain barrier to14C-sucrose, was significantly increased whether urethane or ethanol was used as anaesthetic. This increase was prevented by giving rats on the same diet injections of thiamine twice weekly. Barrier function was normalised by injecting thiamine into deficient rats for just 3 days before biopsy. The brains of the thiamine-deficient rats were stained by the Fink-Heimer method but showed no degenerating axons except for silver grains in the glomeruli of the olfactory bulb. Other rats were maintained on the same diet for 38 days and additionally exposed to ethanol vapour for 16 h per day. This resulted in a similar loss of weight but a greater leakage of the blood-brain barrier. The latter was normalised by a thiamine injection only 24 h before biopsy, but was not reduced by withdrawal of ethanol for 3 days before biopsy. Axonal degeneration was present in the olfactory glomeruli. However, no lesions or extravasated blood cells were seen in any brains, there was no change in brain water indicative of oedema and no degeneration in retina, distal peripheral nerves or leg muscles. The relation of these and other experimental findings to alcohol-related brain damage is considered.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00691858
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  • 5
    Electronic Resource
    Electronic Resource
    Organic lead and histological parameters of brain development (1984)
    Springer
    Acta neuropathologica 63 (1984), S. 306-312 
    Details
    ISSN: 1432-0533
    Keywords: Cerebellum ; Hippocampus ; Lead ; Brain development
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Relatively little work has been done on the structural effects of organic lead in the central nervous system (CNS), although this form of lead may be a significant fraction of total brain lead. We tested a number of easily measured light-histological parameters of neuronal development in rats for sensitivity to (a) normal growth between 18 and 28 days of life and (b) the effect of weekly injections of tetramethyl lead (TML), administered from 1 week after conception until post-natal day 6. Several of the histological parameters were found to be sensitive to normal growth, but none showed any effect of organic lead treatment. This was despite a small but significant decrease in brain weight, and a significant increase in body/brain weight ratio, with tetramethyl lead treatment. The body/brain weight ratio was the parameter most sensitive to tetramethyl lead treatment. Possible reasons for the disparity between weight and histological parameters are discussed, with reference to previous workers' findings concerning the effects of organic lead on the development of myelin in the CNS and the availability of organic lead to brain tissue.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00687338
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  • 6
    Electronic Resource
    Electronic Resource
    Autonomic Functions of the Hippocampus (1958)
    [s.l.] : Nature Publishing Group
    Nature 182 (1958), S. 675-676 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] In rabbits anaesthetized with urethane, pentobarbital sodium or ether, it can be shown that stimulation within the ventral part of the fimbria raises the blood pressure and increases the rate and amplitude of the respiration as illustrated in Fig. 1. Stimulation within the more dorsal part of the ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/182675a0
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  • 7
    Electronic Resource
    Electronic Resource
    Evoked Single Cortical Unit Activity in the Primary Cortical Receiving Areas (1952)
    [s.l.] : Nature Publishing Group
    Nature 169 (1952), S. 971-971 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] I should like to take this opportunity of pointing out an error in the reproduction of my photographs in Nature of February 9, p. 240 ; all the calibration arrows should have been 6-8 mm. long on the scale ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/169971a0
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  • 8
    Electronic Resource
    Electronic Resource
    Changes in Visual Cortex on First Exposure of Rats to Light: Effect on Synaptic Dimensions (1967)
    [s.l.] : Nature Publishing Group
    Nature 215 (1967), S. 251-253 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] It is possible that neuronal activity may produce synaptic changes, although there has so far been no direct evidence for this. Experiments with rats suggest, however, that changes in chemistry and the structure of the synapses in the visual cortex are among the consequences of the exposure of eyes ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/215251a0
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  • 9
    Electronic Resource
    Electronic Resource
    Estimation of the number of synapses in a volume of nervous tissue from counts in thin sections by electron microscopy (1974)
    Springer
    Journal of neurocytology 3 (1974), S. 725-735 
    Details
    ISSN: 1573-7381
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The several methods that have been used to count synapses by electron microscopy are put in error by the inevitable failure to recognize and count all of the smaller profiles of synapses present in a section. The smaller profiles are produced by near-tangential sectioning of synapses of larger diameter, whereas equatorial sections produce large profiles that are always recognized. The expected number of smaller profiles can be calculated from the observed numbers of larger profiles by the method of Coupland (1968). The estimated density is then dependent on the more reliable observations only, but the iterative calculation required is very tedious. This paper describes the calculation (performed by a computer), and discusses the methods available for counting synapses, and the results obtained.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01097194
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  • 10
    Electronic Resource
    Electronic Resource
    A physical theory of the growth of axons (1955)
    Philadelphia : Wiley-Blackwell
    Journal of Cellular and Comparative Physiology 45 (1955), S. 33-60 
    Details
    ISSN: 0095-9898
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Medicine
    Additional Material: 4 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jcp.1030450105
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