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  • 1
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    Biochimica et Biophysica Acta (BBA)/Biomembranes 942 (1988), S. 11-18 
    ISSN: 0005-2736
    Keywords: (Rat lung) ; Sodium ion effect ; Sugar transport ; d-Glucose transport
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology , Medicine , Physics
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1432-1807
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mathematics
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    Journal of cancer research and clinical oncology 115 (1989), S. 388-392 
    ISSN: 1432-1335
    Keywords: Gastrin ; Nude mice ; Cell culture ; Colorectal carcinoma
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The growth-regulating effects of pentagastrin, gastrin and the gastrin-receptor antagonist proglumide were investigated in three established cell lines derived from human colorectal carcinomas in vitro and after transplantation into nude mice. In vitro a significant increase of cell growth in the SW 403 cell line incubated with pentagastrin or gastrin was observed. In the Lovo cell line this effect was only detected after synchronization of cell growth. Pentagastrin and gastrin had no effect on the growth of the Ls 174 T cell line. Proglumide reduced cell proliferation in all three cell lines as well as in the L929S cell line derived from fibroblasts, which served as control. After transplantation into nude mice all tumor cell lines increased, Love and Ls 174 T as undifferentiated tumor, SW 403 as differentiated. Pentagastrin increased and proglumide decreased growth in SW 403 tumors, whereas no effect was observed on Ls 174 T and Lovo tumors. We therefore conclude that growth of some colorectal carcinomas is regulated by gastrin, but that the effect of proglumide is unspecific rather than related to blockage of gastrin receptors. The growth-regulating effect of gastrin could be due to tumor differentiation.
    Type of Medium: Electronic Resource
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  • 4
    ISSN: 1432-1106
    Keywords: Reciprocal inhibition ; Man ; Supraspinal control ; Voluntary movements
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The aim of the study was to examine the supraspinal control during voluntary movements of the foot in man, of the Ia inhibitory interneurones activated from the anterior tibial muscle and projecting to the soleus α-motoneurones. Previous studies have reported an increased inhibition of the soleus α-motoneurones by a constant conditioning stimulus to the common peroneal nerve during dorsiflexion of the foot. This was interpreted as a sign of supraspinal facilitation of the Ia inhibitory interneurones. However, these results could not be reproduced in the present study. The contradictory results can probably be explained by some important methodological differences in the use of the H-reflex technique.
    Type of Medium: Electronic Resource
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  • 5
    ISSN: 1432-1106
    Keywords: Spinal cord ; Spinal reflexes ; Monosynaptic reflex ; Motor control ; Man ; Cat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary In parallel experiments on humans and in the cat it was investigated how the sensitivity of monosynaptic test reflexes to facilitation and inhibition varies as a function of the size of the control test reflex itself. In man the monosynaptic reflex (the Hoffmann reflex) was evoked in either the soleus muscle (by stimulation of the tibial nerve) or the quadriceps muscle (by stimulation of the femoral nerve). In the decerebrate cat monosynaptic reflexes were recorded from the nerves to soleus and medial gastrocnemius muscles; they were evoked by stimulation of the proximal ends of the sectioned L7 and S1 dorsal roots. Various excitatory and inhibitory spinal reflex pathways were used for conditioning the test reflexes (e.g. monosynaptic Ia excitation, disynaptic reciprocal inhibition, cutaneous inhibition, recurrent inhibition, presynaptic inhibition of the Ia fibres mediating the test reflex). It was shown that the additional number of motoneurones recruited in a monosynaptic test reflex by a constant excitatory conditioning stimulus was very much dependent on the size of the test reflex itself. This dependency had the same characteristic pattern whatever the conditioning stimulus. With increasing size of the test reflex the number of additionally recruited motoneurones first increased, then reached a peak (or plateau) and finally decreased. A similar relation was also seen with inhibitory conditioning stimuli. The basic physiological factors responsible for these findings are discussed. Finally, the implications for the interpretation of experiments in man with the H-reflex technique are considered.
    Type of Medium: Electronic Resource
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  • 6
    ISSN: 1432-1106
    Keywords: Spinal cord ; Reciprocal inhibition ; Iaafferents ; Reflex pathways ; H-reflexes
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Recent studies have reported that no increase of the disynaptic reciprocal inhibition can be observed during tonic voluntary dorsiflexion of the foot as compared to rest, when the size of the control H-reflex is kept constant. Other studies have, however, shown that a voluntary contraction evokes a strong and long-lasting depression of the synaptic transmission from Ia afferents to motoneurones, most likely secondary to activation of these afferents during the contraction (post-activation depression). It was thought that this effect could also interfere with the demonstration of a central facilitation of the reciprocal inhibition during movement. The amount of disynaptic Ia reciprocal inhibition from the pretibial flexors to the soleus H-reflex was therefore estimated in normal human subjects at rest and during voluntary tonic dorsiflexion before, during and after blocking the peripheral feedback from the investigated muscles. It was observed that the reciprocal inhibition measured during dorsiflexion increased during occlusion of the blood supply to the leg, reaching a maximum of inhibition after 30 min of ischaemia. After release of the ischaemia the inhibition gradually decreased to its pre-ischaemic level. It is therefore suggested that the brain facilitates transmission in the Ia disynaptic reciprocal pathway during tonic voluntary dorsiflexion of the foot, but that this facilitation is normally not observed due to a post-activation depression following the peripheral feedback activation during the movement.
    Type of Medium: Electronic Resource
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  • 7
    Electronic Resource
    Electronic Resource
    Springer
    Experimental brain research 78 (1989), S. 28-32 
    ISSN: 1432-1106
    Keywords: Hoffmann reflex ; Stimulus frequency ; Long lasting depression ; Reciprocal inhibition ; Man
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary A long lasting inhibition (〉 8 s) of the soleus Hoffmann reflex (H-reflex) was evoked by a preceding soleus H-reflex, by a brief voluntary ankle flexor or extensor muscle contraction or by a tap applied to the Achilles tendon. The time course of this long lasting inhibition was similar in all these cases, suggesting that the same spinal mechanism is involved. Furthermore, it was shown that the post-activation depression may interfere with the determination of inhibitory or facilitatory effects on the H-reflex. It is stressed that when the onset of inhibitory or facilitatory effects on the soleus H-reflex is to be determined in relation to start of an ankle movement, either very long stimulus intervals (〉 8 s) must be used, or the onset must be determined in relation to a reference value of the soleus H-reflex, which may be influenced by the long lasting inhibitory effect, but not yet by the succeeding muscle contraction.
    Type of Medium: Electronic Resource
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  • 8
    ISSN: 1432-1106
    Keywords: Key words Mmax ; Hmax ; Repeated stimulation ; Amplitude decrease ; Soleus muscle
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  It was shown that the amplitude of the soleus M max and H max responses decreases in the course of long-lasting H-reflex studies. The peak-to-peak amplitudes of the M max and H max responses in the soleus muscle (and the M max in the tibialis anterior muscle and small hand muscles) were measured repeatedly for 1–3 h in 20 subjects. 3–5 M max responses and 5–10 H max responses were elicited about every 3 min while the subject was at rest. Decreases in the soleus M max response of up to 50.5% (mean 20.5% SEM 2.2) and of the soleus H max of up to 49.7% (mean 19.1% SEM 3.7) in relation to the amplitudes measured at the beginning of the experiment were seen in 17 subjects. In 3 subjects no M max amplitude decrease was seen. The maximum decrease was reached between 10 and 100 min (mean 44.2 min SEM 4.3). An Mmax amplitude decrease was also seen in the tibialis anterior muscle and in two small hand muscles. In some subjects the decrease of the M max response seemed to be initiated by the infrequent supramaximal stimulations. The possible causes for this amplitude reduction, as well as the methodological consequences of these findings for H-reflex studies and fatigue studies, are briefly discussed.
    Type of Medium: Electronic Resource
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  • 9
    Electronic Resource
    Electronic Resource
    Springer
    Experimental brain research 104 (1995), S. 99-106 
    ISSN: 1432-1106
    Keywords: H-reflex ; Motoneurones ; Presynaptic inhibition ; Reciprokal inhibition ; Voluntary movement
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The size of the soleus Hoffmann reflex (H-reflex) was measured in six healthy human subjects before and after transmission in the common peroneal nerve (CPN) was blocked reversibly by local injection of lidocaine. It was found that the H-reflex at rest increased after the block. When the subjects attempted to perform a dorsiflexion while the CPN was blocked (“fictive dorsi flexion”), the soleus H-reflex was strongly depressed. Stimulation of the CPN proximal to the block elicited a short-latency inhibition of the soleus H-reflex, which was probably mediated by reciprocal Ia interneurones. This inhibition never increased during dorsiflexion relative to rest prior to the CPN block, but after the block a significant increase in inhibition was seen during fictive dorsiflexion in three subjects. Stimulation of the femoral nerve (FN) elicited a short-latency monosynaptic Ia facilitation of the soleus H-reflex. This facilitation was found to decrease during dorsiflexion relative to rest before the block as well as during fictive dorsiflexion after the block. The decrease in the H-reflex during fictive dorsiflexion demonstrates that although an increased Ia afferent feedback via the gamma-loop may contribute to reciprocal inhibition when transmission in the CPN is intact, a noticeable, centrally mediated inhibition may occur in the absence of this feedback. It is suggested that this inhibition is caused by central facilitation of interneurones mediating disynaptic Ia inhibition as well as interneurones mediating presynaptic inhibition of Ia afferents.
    Type of Medium: Electronic Resource
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  • 10
    Electronic Resource
    Electronic Resource
    Springer
    European journal of applied physiology 66 (1993), S. 116-121 
    ISSN: 1439-6327
    Keywords: Ballet dancers ; H-reflexes ; Ia afferents ; Reciprocal inhibition ; Reflex pathways ; Spinal cord ; Training
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The size of the maximalH-reflex (H max) was measured at rest and expressed as a percentage of the maximalM-response (M max) in 17 untrained subjects, 27 moderately trained subjects, 19 well-trained subjects and 7 dancers from the Royal Danish Ballet. TheH max/M max was significantly larger in the moderately and well-trained subjects than in the untrained subjects but smaller in the ballet dancers. It is therefore suggested that both the amount and the type of habitual activity may influence the excitability of spinal reflexes.
    Type of Medium: Electronic Resource
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