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  • 1
    ISSN: 1365-2036
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: : To compare lansoprazole 30 mg once daily, lansoprazole 15 mg once daily and ranitidine 150 mg once nightly in the prevention of duodenal ulcer relapse in patients whose duodenal ulcers had been previously healed with lansoprazole 30 mg once daily or ranitidine 300 mg nightly.〈section xml:id="abs1-2"〉〈title type="main"〉Methods: A double-blind, parallel group, randomized multicentre study conducted in 33 centres in the UK, Eire, Sweden and Australia. Two hundred and nineteen patients with a duodenal ulcer were randomized to receive lansoprazole 30 mg and 217 to receive ranitidine 300 mg for 8 weeks. Patients were then re-randomized to receive lansoprazole 30 mg (122 patients), lansoprazole 15 mg (121 patients) or ranitidine 150 mg (116 patients) for 12 months. All patients had an endoscopically-proven duodenal ulcer at baseline and were considered suitable for long-term maintenance therapy to prevent relapse.〈section xml:id="abs1-3"〉〈title type="main"〉Results: Significantly more patients were healed on lansoprazole (98%) compared to ranitidine (89%) (P 〈 0.001, Fisher's exact test). Lansoprazole provided more rapid symptom relief than ranitidine. Lansoprazole 30 mg and lansoprazole 15 mg increased the probability of not relapsing in comparison to ranitidine (P = 0.001 and 0.06, respectively, life-table analysis). Relapse rates over the 12 months were lower in the lansoprazole treatment groups (lansoprazole 30 mg, 5%; lansoprazole 15 mg, 12%; and ranitidine, 21%; lansoprazole 30 mg vs. ranitidine 150 mg, P = 0.002). Symptoms were well controlled in both groups during the maintenance phase. All treatments were well tolerated with no major differences seen in adverse event profiles between treatment groups.〈section xml:id="abs1-4"〉〈title type="main"〉Conclusions: Both doses of lansoprazole (30 mg and 15 mg) were superior to ranitidine 150 mg in the prevention of duodenal ulcer relapse. Lansoprazole was superior to ranitidine in terms of symptom control and duodenal ulcer healing. Both treatments were well tolerated.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Chichester [u.a.] : Wiley-Blackwell
    International Journal for Numerical Methods in Engineering 10 (1976), S. 301-343 
    ISSN: 0029-5981
    Keywords: Engineering ; Engineering General
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mathematics , Technology
    Notes: This paper is concerned with the development of a numerical procedure for solving complex boundary value problems in plane elastostatics. This procedure - the displacement discontinuity method - consists simply of placing N displacement discontinuities of unknown magnitude along the boundaries of the region to be analyzed, then setting up and solving a system of algebraic equations to find the discontinuity values that produce prescribed boundary tractions or displacements. The displacement discontinuity method is in some respects similar to integral equation or ‘influence function’ techniques, and contrasts with finite difference and finite element procedures in that approximations are made only on the boundary contours, and not in the field. The method is illustrated by comparing computed results with the analytical solutions of two boundary value problems: a circular disc subjected to diametral compression, and a circular hole in an infinite plate under a uniaxial stress field. In both cases the numerical results are in excellent agreement with the exact solutions.
    Additional Material: 13 Ill.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    International journal of fracture 67 (1994), S. 1-20 
    ISSN: 1573-2673
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Abstract This paper presents the development of a higher-order direct boundary integral-displacement discontinuity method for crack propagation in layered elastic materials. The method is based on the dual boundary integral equations of linear elasticity which are solved by means of a quadratic boundary element formulation. The analytical solution for a point force within a bonded half-plane region is used to derive the kernel functions of the boundary integral equations. Square-root displacement-discontinuity elements are used to model the crack tips, and stress intensity factors may be computed using the numerically predicted values of the displacement discontinuity components at the midpoints of these crack-tip elements. An algorithm based on the maximum tensile-stress criterion is then developed and incorporated into the boundary element model to predict the paths of cracks propagating in layered elastic materials. In the experimental part of this study, crack profiles for straight-through-cracked, compact-tension specimens of the anodically bonded silicon/Pyrex glass system are measured by profilometry. The plane strain prediction of the crack-propagation path is compared with the experimentally measured crack profiles. Consistent with the prediction, the interfacial crack is observed to kink away from the strong, anodically-bonded interface and propagate into the more compliant glass layer. The predicted initial kink angle of 26° agrees very well with the average measured value of 28°. The measured path of the crack is also in very good agreement with the predicted path over about the first 120 microns of crack growth with increasing deviation observed beyond that.
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Chichester [u.a.] : Wiley-Blackwell
    International Journal for Numerical Methods in Engineering 42 (1998), S. 1045-1069 
    ISSN: 0029-5981
    Keywords: elastodynamics ; boundary elements ; higher order ; analytical integration ; multi-domain ; Engineering ; Numerical Methods and Modeling
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mathematics , Technology
    Notes: A general higher-order formulation for the time domain elastodynamic direct boundary element method is presented for computing the transient displacements and stresses in multiply connected two-dimensional solids. The displacement and traction interpolation functions are linear in time and quadratic in space. All integrations are analytical, and are expressed in terms of twelve basic recurring integrals. Causality is ensured by integrating only over the dynamically active parts of each element, and the algorithm presented is time-marching and implicit. The use of analytical integrations allows both unbounded and bounded domain problems to be solved without having to introduce special enclosing elements. All of these improved features allow for a formulation that is very efficient and accurate. The stability and accuracy of the elastodynamic boundary element algorithm is demonstrated by solving several example problems and comparing the results with available analytical and numerical solutions. © 1998 John Wiley & Sons, Ltd.
    Additional Material: 16 Ill.
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Chichester [u.a.] : Wiley-Blackwell
    International Journal for Numerical Methods in Engineering 37 (1994), S. 3229-3250 
    ISSN: 0029-5981
    Keywords: Engineering ; Engineering General
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mathematics , Technology
    Notes: A time-domain elastodynamic displacement discontinuity method is presented for analysing two-dimensional problems in solid mechanics. Linear, continuous in time and piecewise linear in space interpolation functions are assumed for the displacement discontinuities. Causal and analytical integrations are used throughout. The resulting numerical algorithms are time marching and implicit. The displacement discontinuity method can be used to model a class of traction boundary value problems, where the unknowns are the transient shear and normal discontinuities in displacement across the surface of a mathematical crack in an infinite, isotropic and homogeneous linear elastic medium.
    Additional Material: 14 Ill.
    Type of Medium: Electronic Resource
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