ISSN:
1420-908X
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract CI-949 (5-methoxy-3-(1-methylethoxy)-1-phenyl-N-1H-tetrazol-5-yl-1H-indole-2-carboxamide,l-arginine salt), an antiallergy compound was found to be a weak inhibitor of IL-1 release from LPS-stimulated murine peritoneal exudate cells and human peripheral blood leukocytes, with IC50s of 186.2 and 267.9 μM, respectively. CI-949 was also a poor inhibitor of release of IL-2 from Con A-stimulated rat spelenocytes (37% inhibition at 100 μM). CI-949 did produce concentration-related inhibition of the response of human lymphocytes to PHA and Con A (IC50s=44.7 and 21.5 μM, respectively) as well as in the mixed lymphocyte reaction (MLR) (IC50=16.8 μM). The clinical significance of these latter findings is unknown at present.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01972805
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