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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Entomologia experimentalis et applicata 7 (1964), S. 139-143 
    ISSN: 1570-7458
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Description / Table of Contents: Zusammenfassung Mückenlarven (Aedes aegypti) nahmen um so größere Mengen von 14C-markiertem DDT auf, je mehr die Temperatur anstieg. Im Gegensatz dazu zeigte die prozentuale Mortalität einen negativen Temperaturkoeffiziente. Die Untersuchungstemperaturen betrugen 10, 20 und 30°. Eine ähnliche DDT-Aufnahme-Beziehung ergab sich, wenn Köpfe, Brustabschnitte oder Abdomina der Larven getrennt verglichen wurden. Bei 30 und 20° wiesen die Brustabschnitte größere Konzentrationen auf als die Köpfe und Abdomina. Bei 10° enthielten die Köpfe mehr als die Abdomina und Brustabschnitte, aber die aufgenommene Menge war doch geringer als bei 20 und 30°. Die Ergebnisse zeigen einen positiven Temperaturkoeffizienten für die DDT-Aufnahme, aber einen negativen für die prozentuale Mortalität unter der Voraussetzung, daß die DDT-konzentration nicht zu hoch ist. Die zweite Beziehung stimmt mit beträchtlich früheren Untersuchungen überein. Eine Erklärung für diesen negativen Temperatureffekt des DDT ist noch nicht gefunden, aber es scheint, daß diese Wirkung keine positive Korrelation zur DDT-Aufnahme ganzer Larven oder bei Teilen ganzer Larven aufweist.
    Notes: Abstract Mosquito larvae, Aedes aegypti, picked up progressively greater amounts of C14 labeled DDT with ascending temperatures. The pick-up relationship contrasted with per cent mortality which showed a negative temperature coefficient. The exposure temperatures were 10°, 20° and 30° C. A similar relationship of pick-up of DDT occurred when heads, thoraces, or abdomens of the larvae were compared separately. The thorax contained greater concentrations than heads or abdomens at 30° and 20° C. At 10° C the heads contain more than thoraces and abdomens, but the amount was still less than that picked up at 20° and 30° C. The results show a positive coefficient of pick-up of DDT but a negative temperature coefficient for per cent mortality provided the concentration of DDT is not too high. The latter relationship agrees with considerable earlier research. The explanation for the negative temperature effect of DDT is still not understood, but we have evidence that the effect is not positively related to pick-up by whole larvae or portions of whole larvae.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Bulletin of environmental contamination and toxicology 29 (1982), S. 577-585 
    ISSN: 1432-0800
    Source: Springer Online Journal Archives 1860-2000
    Topics: Energy, Environment Protection, Nuclear Power Engineering , Medicine
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    Bulletin of environmental contamination and toxicology 14 (1975), S. 163-167 
    ISSN: 1432-0800
    Source: Springer Online Journal Archives 1860-2000
    Topics: Energy, Environment Protection, Nuclear Power Engineering , Medicine
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Springer
    Bulletin of environmental contamination and toxicology 7 (1972), S. 87-92 
    ISSN: 1432-0800
    Source: Springer Online Journal Archives 1860-2000
    Topics: Energy, Environment Protection, Nuclear Power Engineering , Medicine
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Springer
    Archives of environmental contamination and toxicology 3 (1975), S. 132-141 
    ISSN: 1432-0703
    Source: Springer Online Journal Archives 1860-2000
    Topics: Energy, Environment Protection, Nuclear Power Engineering , Medicine
    Notes: Abstract Fat head minnows, 45-days old, were continuously exposed to DDT using continuous water flow and constant temperature conditions. Exposures were to 0.5 and 2.0 ppb of DDT in water, and combinations of the two concentrations with 50 ppm in food, and 50 ppm in food alone, using C14-DDT in food. Brain homogenates were analyzed for enzyme activity from fish treated for 56, 118, 225, and 266 days; and gill analysis was made at 225 and 226 days exposure. Enzyme reductions were greatest in oligomycin-sensitive (mitochondrial) Mg2+ ATPase, with pronounced effects (over 50% inhibition) at the 266th sampling day. In contrast, Na+-K+ ATPase and oligomycin-insensitive Mg2+ ATPase activities were activated by as much as 28% and 40%, respectively. Mitochondrial Mg2+ ATPase of fish brain has been inhibited to the greatest extent in previously reportedin vitro studies. All three ATPase enzymes were reduced in gill tissue sampled at the 266th day, with mitochondrial Mg2+ ATPase showing the greatest decline.
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    Springer
    Archives of environmental contamination and toxicology 11 (1982), S. 627-633 
    ISSN: 1432-0703
    Source: Springer Online Journal Archives 1860-2000
    Topics: Energy, Environment Protection, Nuclear Power Engineering , Medicine
    Notes: Abstract Interspecific and inter-tissue differences were found in thein vitro sensitivity of oligomycin sensitive Mg2+ATPase (O.S.-ATPase) from avian mitochondrial homogenates to DDE. The enzyme from the “target” tissue, the shell gland of kestrels, which lay thin-shelled eggs on exposure to DDE, showed significantly greater sensitivity to DDE than O.S.-ATPase in muscle and brain preparations. The O.S.-ATPase from chicken shell gland was about nine times less sensitive than that from the kestrel. DDT, in contrast to DDE, was highly effective on O.S.-ATPase in all tissues tested from the three species of birds. In contrast to the high sensitivity of O.S.-ATPase, O.Ins.-ATPase and Na+-K+ATPase were not significantly affected by DDE or DDT. In addition, Ca2+-ATPases from mitochondrial and microsomal preparations from shell gland of kestrels were only minimally affected by DDT and DDE at concentrations over 20 times greater than those which inhibited O.S.-ATPase. The selectivity of DDE action in the eggshell thinning of kestrel is correlated with its action on shell gland O.S.-ATPases. However, because DDT effectively inhibits O.S.-ATPase from all tissues studied a combined effect is possible. Both would cause a reduction in ATP synthesis affecting energy-linked calcium transport. The need forin vivo studies including mitochondrial calcium transport is emphasized.
    Type of Medium: Electronic Resource
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  • 7
    Electronic Resource
    Electronic Resource
    [s.l.] : Nature Publishing Group
    Nature 233 (1971), S. 61-62 
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] It is known that PCB ('Aroclor 1242') will cause oedema and depress growth when fed to chicks in large amounts (200 and 400 p.p.m. in diet), the rate of steroid metabolism is increased in liver homogenates from birds dosed with PCBs and that the materials stimulate oestrogenic activity in the rat ...
    Type of Medium: Electronic Resource
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  • 8
    Electronic Resource
    Electronic Resource
    Springer
    Experimental and applied acarology 3 (1987), S. 109-113 
    ISSN: 1572-9702
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract The synthetic pyrethroids bioallethrin,d-phenothrin, and fenvalerate, when tested by the slidedip technique, were more toxic to female two-spotted spider mites,Tetranychus urticae Koch, at 30°C than at 20°C. LC50 values differed by 1.7-, 3.8-, and 5.3-fold, respectively. Two other synthetic pyrethroids, flucythrinate and cyfluthrin, gave similar toxicity values at these two temperatures. The greater sensitivity ofT. urticae at a warmer temperature to the first three pyrethroids differs from insect toxicity studies, which often show negative temperature relationships.
    Type of Medium: Electronic Resource
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  • 9
    Electronic Resource
    Electronic Resource
    New York, NY [u.a.] : Wiley-Blackwell
    Archives of Insect Biochemistry and Physiology 1 (1983), S. 267-280 
    ISSN: 0739-4462
    Keywords: inhibitory probes ; mitochondrial ATPase ; inhibition kinetics ; relative potency ; joint action ; Chemistry ; Food Science, Agricultural, Medicinal and Pharmaceutical Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology
    Notes: Chemical inhibitors were used as probes of mitochondrial ATPase to determine the site of action of DDT on oligomycin-sensitive mitochondrial ATPase (OS-ATPase) using whole mitochondria isolated from red coxal muscle of the American cockroach. Several plotting procedures were employed to delineate the form of inhibition. Relative potency and joint action were used to detect similar action, synergism, and antagonism between DDT and the inhibitory probes DCCD, Nbf-CI, and oligomycin. DDT demonstrated not (strictly) competitive kinetics and may be acting as an uncompetitive inhibitor. DDT and DCCD produced similar additive action. At limiting concentrations of DCCD, inhibition was reduced in the presence of DDT. Effects shown by oligomycin were not altered by DDT. DDT enhanced the effects of Nbf-CI. These interactions, together with the demonstration of not (strictly) competitive kinetics, indicate that DDT may be acting on the membrane sector as an allosteric modifier.
    Additional Material: 6 Ill.
    Type of Medium: Electronic Resource
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