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  • 1
    Electronic Resource
    Electronic Resource
    Effect of gastric pH on the relative oral bioavailability and pharmacokinetics of temozolomide (1999)
    Springer
    Cancer chemotherapy and pharmacology 44 (1999), S. 389-394 
    Details
    ISSN: 1432-0843
    Keywords: Key words Temozolomide ; MTIC ; Pharmacokinetics ; Gastric pH ; Phase I trial ; Heidelberg capsule
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Purpose: Temozolomide is an imidazotetrazine alkylating agent which undergoes chemical conversion at physiological pH to the active species 5-(3-methyltriazene-1-yl)imidazole-4-carboxamide (MTIC) but is stable at acid pH. This study evaluated the effect of an increase in gastric pH, through the use of ranitidine, on the oral bioavailability and plasma pharmacokinetics of temozolomide and MTIC. Methods: Fifteen patients with advanced cancer were enrolled of which 12 were evaluable, all of whom had pharmacokinetic blood sampling. Each patient received temozolomide 150 mg m−2 day−1 for 5 days in cycle 1 and also received ranitidine 150 mg every 12 h either on days 1 and 2 or days 4 and 5. Gastric pH was monitored by the use of the Heidelberg capsule system. Results: Following the administration of ranitidine there was a rise in gastric pH by 1–2 pH units over the duration of the study period (pH range 2.2–5.2 without ranitidine and 3.5–6.0 with ranitidine). There was no difference in the pharmacokinetic parameters of temozolomide or MTIC with or without the concomitant administration of ranitidine. There was however, a lower Cmax for temozolomide and MTIC for patients receiving ranitidine on day 1 and 2 versus day 4 and 5. Temozolomide was rapidly absorbed [time to maximum plasma concentration (t max) 1.8 h] and eliminated [elimination half-life (t 1/2) 1.8 h] and MTIC followed a similar pattern with a t max of 1.9 h and a t 1/2 of 1.9 h. Overall, the AUC of the MTIC represented about 2–4% of the AUC for temozolomide.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002800050994
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  • 2
    Electronic Resource
    Electronic Resource
    Mental Health in the Oregon Health Plan: Fragmentation or Integration? (1998)
    Springer
    Administration and policy in mental health and mental health services research 25 (1998), S. 361-386 
    Details
    ISSN: 1573-3289
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine , Psychology
    Notes: Abstract The Oregon Health Plan was implemented in 1994 with a 50% expansion of Medicaid enrollment to include some of the working poor. Over 75% of Oregon Medicaid clients are now enrolled in health maintenance organizations (HMOs). Outpatient chemical dependency services have been capitated since May 1995. Capitated mental health services have been provided for the 25% of eligibles who live in demonstration counties since January 1995. Expansion and capitation appear to have been achieved without major trauma. More challenging has been the attempted integration of public sector behavioral health services with private sector health plans. Stakeholders interviewed for this study were especially concerned about the long-term impact on Medicaid clients with chronic mental illness. Strong leadership and clear policies regarding the mixture of public, private nonprofit, and private for profit entities are necessary if the state is to achieve its aim of integration without fragmenting a system of care for people with severe mental illness.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1022249606959
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  • 3
    Electronic Resource
    Electronic Resource
    Clinical, hematologic, and immunologic effects of interleukin-10 in humans (1996)
    Springer
    Journal of clinical immunology 16 (1996), S. 291-303 
    Details
    ISSN: 1573-2592
    Keywords: Cytokines ; interleukin-6 ; interleukin-8 ; interferon-γ ; Th1 and Th2 lymphocytes
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We conducted a double-blind, placebo-controlled study to investigate the safety, pharmacokinetics, and immunological properties of interleukin-10 (IL-10) administration in healthy humans. Volunteers received a single intravenous bolus injection of recombinant human IL-10 (1, 10, or 25μg/kg) or placebo. Cytokine production in whole blood and peripheral blood mononuclear cells (PBMC) was assessed before and 3, 6, 24, and 48 hr after the injection. Peak serum concentrations of IL-10 (15±1.1, 208±20.1, and 505±22.3 ng/ml) occurred after 2–5 min for 1, 10, and 25μg/kg IL-10, respectively. The terminal-phase half-life was 3.18 hr. A transient leukocytosis (24–63% above baseline) was observed 6 hr after injection, which coincided with a dose-dependent decrease (12–24%) in neutrophil superoxide generation. There was a marked inhibition (60–95%) of endotoxin-induced IL-6 production from whole blood in each group receiving IL-10. Production of IL-8 in endotoxin-stimulated blood was reduced in the 10μg/kg group. In PBMC stimulated with phytohemagglutinin and phorbol ester, there was a decrease (72–87%) in interferon-γ (IFNγ) production 6 hr after IL-10 with a return to pre-IL-10 levels after 24 hr. This reduction was only partially associated with a decrease in the number of CD2-bearing cells. We conclude that IL-10 administration into humans is without significant side effects, and a single injection reducesex vivo production of IL-6, IL-8, and IFNγ.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01541395
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  • 4
    Electronic Resource
    Electronic Resource
    Developing a comprehensive state mental health plan (1984)
    Springer
    Administration and policy in mental health and mental health services research 12 (1984), S. 26-39 
    Details
    ISSN: 1573-3289
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine , Psychology
    Notes: Abstract The authors review the history of state mental health planning from the federal perspective, discuss some state objectives for comprehensive planning, and present a participatory model for plan development. They demonstrate how the model can be used as a theoretical framework to produce a mental health plan that is a viable management tool fulfilling many state objectives.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00818535
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  • 5
    Electronic Resource
    Electronic Resource
    Collaboration for training (1993)
    Springer
    Administration and policy in mental health and mental health services research 20 (1993), S. 449-458 
    Details
    ISSN: 1573-3289
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine , Psychology
    Notes: Abstract Training has been a longstanding and fruitful area of collaboration between the public and academic sectors. Graduate medical education for psychiatry residents is one example. This paper reviews the history of Oregon's public psychiatry training program and highlights factors contributing to its success.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00706289
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  • 6
    Electronic Resource
    Electronic Resource
    State hospital curriculum: Public academic liaison for psychiatric education (1993)
    Springer
    Administration and policy in mental health and mental health services research 20 (1993), S. 459-469 
    Details
    ISSN: 1573-3289
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine , Psychology
    Notes: Abstract State hospitals provide essential services to many of society's most ill and needy individuals. As the next century approaches, state hospitals can best fulfil their missions by developing as high-quality neuropsychiatric/rehabilitation institutes, as opposed to custodial care centers. Highly skilled professionals whose education has included the special knowledge and skill pertinent to state hospitals are central to this development. Although “training units” in state hospitals have existed in many locales, a specific curriculum is often lacking. This article describes the curriculum for psychiatric residents who rotate through the Professional Education Unit at Dammasch State Hospital, as part of the Oregon Public Psychiatry Training Program. The curriculum is described by exploration of the individual learning contract, known as the “Educational Plan,” which guides each resident's work.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00706290
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  • 7
    Electronic Resource
    Electronic Resource
    A comparison of schizophrenic patients in different community support treatment approaches (1987)
    Springer
    Community mental health journal 23 (1987), S. 103-113 
    Details
    ISSN: 1573-2789
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Recent advances in the care of the chronically mentally ill in the community have resulted in a “community support system” approach to maintaining chronically mentally ill persons outside the hospital. Yet, very little is known of what a community support system actually is for the chronic mental patient. This paper looks at three different sorts of community support programs and compares a sample of patients within them with respect to network variables, role performance, and demographic variables. Implications regarding the use of network oriented approaches are discussed and directions for further research are explored.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00757164
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  • 8
    Electronic Resource
    Electronic Resource
    Foreword to 25th anniversary of Community Mental Health Journal (1990)
    Springer
    Community mental health journal 26 (1990), S. 5-7 
    Details
    ISSN: 1573-2789
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00752672
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  • 9
    Electronic Resource
    Electronic Resource
    Editor's note (1992)
    Springer
    Community mental health journal 28 (1992), S. 3-4 
    Details
    ISSN: 1573-2789
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00756696
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  • 10
    Electronic Resource
    Electronic Resource
    Substance abuse in severely mentally Ill patients: Why is there a problem? (1993)
    Springer
    Community mental health journal 29 (1993), S. 193-194 
    Details
    ISSN: 1573-2789
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00756344
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    Paper (German National Licenses)
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