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  • 1
    Electronic Resource
    Electronic Resource
    The altered expression of MHC-class II determinants on monocytes of cancer patients (1988)
    Springer
    Cancer immunology immunotherapy 27 (1988), S. 171-176 
    Details
    ISSN: 1432-0851
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The expression of MHC class II determinants Ia.7 (detected by cross reactive mouse anti-Iak antibody) and HLA-DR on monocytes (MO) of gastric and colorectal cancer patients was examined. An increased proportion of MO bearing the Ia.7 determinant was found, while the number of MO expressing DR was not elevated. In gastric cancer patients the increased expression of the Ia.7 determinant was most pronounced in advanced cancer (stage IVA and IVB). The increased expression of this determinant was related to the presence of the tumour as the number of MO expressing Ia.7 decreased 6 months following surgical resection of the tumour. Further, the increased expression of Ia.7 on MO correlated with the tumour infiltration of the serosa. The Ia.7 determinants were mainly expressed on MO which also expressed the receptor for the Fc part of immunoglobulin. Immunostaining in cellular infiltrates surrounding the tumour revealed that Ia.7+ macrophages (MØ) were more numerous than in normal gastric mucosa and severe chronic gastritis and were mostly present in close proximity to tumour cells, while DR+ MØ were mainly localized within the stromal tissue of the tumour and their number was not increased in cancer infiltrates. These observations indicate that the Ia.7+ subpopulation of MØ may be involved in the anti-tumour response of the host.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00200023
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Tumour-cell-induced production of tumour necrosis factor by monocytes of gastric cancer patients receiving BCG immunotherapy (1993)
    Springer
    Cancer immunology immunotherapy 36 (1993), S. 127-132 
    Details
    ISSN: 1432-0851
    Keywords: Tumour necrosis factor ; Monocytes ; Gastric cancer ; BCG immunotherapy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Human peripheral blood monocytes cocultured with tumour cells were used as an in vitro model of in situ interactions between tumour-infiltrating macrophages and the tumour. Tumour cells stimulated de novo expression of the human tumour necrosis factor α (TNF) gene in monocytes and caused the release of TNF into the culture supernatant. A group of 14 patients with stage IVA gastric cancer receiving adjuvant chemotherapy (5-FU, Adriamycin, mitomycin C: FAM) or immunochemotherapy (BCG+FAM) was investigated for the ability of monocytes to produce TNF in vitro upon stimulation with tumour cells or purified protein derivative of tuberculin (PPD). Patients were followed at biweekly intervals, i.e. before each instillation of BCG epicutaneously over a period of 10 weeks. It was found that monocytes of some patients receiving BCG at the end of the observation period had an enhanced ability to produce TNF following stimulation with tumour cells. In contrast, such production was not substantially altered during the study period in patients on chemotherapy. PPD-induced TNF production was much weaker and was not significantly changed during this observation time. We infer that BCG immunotherapy may induce the subtle changes in some cancer patients that lead to an increased interaction between monocytes and tumour cells and result in enhanced production of cytokine(s) with antitumour properties.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01754413
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Cytostatic activity on tumour cells of monocytes from patients with gastrointestinal cancer (1982)
    Springer
    Cancer immunology immunotherapy 13 (1982), S. 190-193 
    Details
    ISSN: 1432-0851
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The ability of monocytes from patients with gastrointestinal cancer to inhibit tumour cell growth and suppress PHA-induced lymphocyte response in vitro was assessed. Isolated monocytes, i.e., adherent Fc+ cells from mononuclear cell suspension, were cytostatic but not cytolytic for both K562 line and L1210 lymphoma cells. Monocytes from the patients showed an increased ability to inhibit the growth of L1210 but not K562 line cells. The increased cytostatic activity of monocytes was associated with their suppressor activity. This suggests that suppressor monocytes are also able to arrest tumour cell growth in vitro.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00205387
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    “Activated” monocytes in gastric cancer patients (1982)
    Springer
    Journal of cancer research and clinical oncology 104 (1982), S. 181-190 
    Details
    ISSN: 1432-1335
    Keywords: Gastric cancer ; Monocytes ; Fc receptor ; ADCC ; NBT reduction ; “Activation”
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The Fc receptor expression, antibody-dependent cellular cytotoxicity (ADCC), and nitro-blue tetrazolium (NBT) reduction of peripheral blood monocytes from 150 patients with different stages of gastric cancer was assessed and compared with results obtained in 77 normal persons and 104 patients with non-malignant diseases of the gut. Monocytes of cancer patients showed an increased ability to form rosettes with human 0, Rh+ erythrocytes coated with D-specific antibody. ADCC and NBT reduction were also elevated but no correlation was found with the stage of disease. However, all these phenomena were related to the tumor load as elevated values were the same 4–6 months after surgery in the unresectable-tumor group, while they decreased in patients with resectable tumors. These observations suggest that monocytes of some cancer patients are functionally altered (“activated”) in the course of disease.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00402066
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  • 5
    Electronic Resource
    Electronic Resource
    “Activated” monocytes in gastric cancer patients (1982)
    Springer
    Journal of cancer research and clinical oncology 104 (1982), S. 307-313 
    Details
    ISSN: 1432-1335
    Keywords: Gastric cancer ; Monocytes ; Suppressor cells ; Cytostatic activity ; “Activation”
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The spontaneous nitro-blue tetrazolium (NBT) reduction of monocytes from patients with gastric cancer was assessed and compared with an in vitro monocyte-mediated cytostasis of tumor cell lines and their suppressor activity. The increased NBT reduction correlated with the ability of monocytes to inhibit mitogen-induced normal lymphocyte response and cytostatic activity against L-1210 murine lymphoma cell line. These observations suggest that “activated” monocytes of some cancer patients may play the role of suppressor cells and exert an anti-tumor effect in vitro.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00406249
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    Paper (German National Licenses)
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  • 6
    Electronic Resource
    Electronic Resource
    Serial immunological testing in patients with gastric cancer (1986)
    Springer
    Journal of cancer research and clinical oncology 111 (1986), S. 62-70 
    Details
    ISSN: 1432-1335
    Keywords: Gastric cancer ; Cellular immunity ; T lymphocytes ; Monocytes ; Follow up
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Standard immunological parameters measuring non-specific cellular immune reactivity were determined in 175 patients with different stages of gastric cancer prior to surgery and during follow-up. Several tests measuring monocyte activity were also employed. The total number of T cells and their subpopulations Ta and T29° was unchanged except depression of T29° in stage IV. The blastogenic response of lymphocytes to PHA as assessed by stimulation of protein synthesis was only depressed in stage IV. In contrast the PHA-induced lymphokine production was increased in all patients but the differences were significant for stage III and IV. Monocyte Fc receptor expression was increased in stages II-IV, while nitro blue tetrazolium reduction and antibody dependent cellular cytotoxicity of monocytes was elevated in stage IV. The number of extractable monocytes was not increased. Longitudinal studies suggested that most of the parameters normalized during follow-up. No major long-term impact of chemoimmunotherapy (5-FU+BCG) on the immune parameters was observed except a transient increase in PPD reactivity approximately 1 year after commencement of treatment. In patients with stage III gastric cancer the increased occurrence of suppressor cells (mostly monocytes) and elevated cytostatic activity of monocytes was associated with a longer survival while the increased lymphokine production and Fc receptor expression were seen in the group of patients succumbing earlier. We concluded that most of the changes in immune parameters were seen only in advanced disease and paradoxically disappeared in the course of disease. The determination of monocyte activity seems to be a sensitive indicator of immune system dearrangements in earlier stages of cancer and a useful prognostic factor in gastric cancer.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00402779
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  • 7
    Electronic Resource
    Electronic Resource
    Serial immunological testing in patients with Gastric Cancer (1986)
    Springer
    Journal of cancer research and clinical oncology 111 (1986), S. 295-295 
    Details
    ISSN: 1432-1335
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00389249
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