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  • 1
    Electronic Resource
    Electronic Resource
    Comparison of five methods for concentrating progenitor cells in human marrow transplantation (1990)
    Springer
    Annals of hematology 60 (1990), S. 278-281 
    Details
    ISSN: 1432-0584
    Keywords: Stem cell concentration ; Bone marrow processing ; Marrow transplantation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Enrichment of bone marrow (BM) aspirates is an important prerequisite prior to in vitro treatment or cryopreservation. In this regard, we have analyzed the results obtained on 190 BM processed by the following 5 techniques: HES sedimentation with centrifugation; COBE 2991 blood cell processor; Ficoll/hypaque (F/H) gradient centrifugation; Continuous flow cell separator (CS 3000 Fenwal); Semicontinuous blood cell separator (Dideco T 90). Each procedure was evaluated by measuring the recovery of nucleated marrow cells (NC), mononuclear cells (MNC), committed progenitor cells (CFUGM), the reduction of BM volume and the removal of red blood cells (RBC) and polymorphonuclear cells (PMN). The results of this comparative study show that F/H gradient on a COBE 2991 cell washer provides the most efficient system for purifying a MNC fraction (89% recovery) from unwanted cells (RBC 〈 2% and PMN 〈 2%) in a very small volume (98% reduction) with a good recovery of CFU-GM (80%).
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01736228
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  • 2
    Electronic Resource
    Electronic Resource
    Patterns of infection in 41 patients with idiosyncratic drug-induced agranulocytosis (1991)
    Springer
    Annals of hematology 63 (1991), S. 84-88 
    Details
    ISSN: 1432-0584
    Keywords: Drug-induced agranulocytosis ; Infections ; Antimicrobial therapy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary We examined the patterns of infection in 41 consecutive patients with idiosyncratic drug-induced agranulocytosis observed during the past 15 years. All patients were nursed in reverse isolation and treated prophylactically with oral antimicrobials and antifungal compounds. Nine of 41 patients remained without fever and did not need any parenteral antibiotic treatment for full recovery. The other 32 patients developed fever during the period of agranulocytosis and were treated with empirical antimicrobial therapy. Febrile episodes were documented microbiologically in 16 patients (eight with and eight without bacteremia) and clinically in six patients. In the other ten cases the fever was of unexplained origin. The observed pattern of infection was in accordance with the type of infection as reported in cancer patients during the granulocytopenic phase induced by cytotoxic drugs. Ten of 32 febrile patients showed improvement after empirical antimicrobial therapy, whereas three patients died, two of them of a lower respiratory tract infection and one of a massive hemorrhage due to necrosis of the carotid artery. In ten patients the signs and symptoms of infection resolved only after adjustment of the initial empirical scheme. In nine patients the fever persisted even after additional empirical antifungal therapy but subsided after recovery of the granulocytopenia.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01707278
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Occurrence of bacteremia in hematologic patients (1992)
    Springer
    European journal of epidemiology 8 (1992), S. 687-692 
    Details
    ISSN: 1573-7284
    Keywords: Bacteremia ; Hematologic patients ; Risk factors
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract In the present study we reviewed eighty-six episodes of bacteremia occurred in 60 neutropenic patients and thirty-one episodes occurred in 30 non-neutropenic patients. Twenty-four out of 60 neutropenic patients suffered from multiple episodes of bacteremia, while only one out of 30 non neutropenic patients presented multiple episodes. In neutropenic patients, 29 episodes of bacteremia were polymicrobial, whereas only one non-neutropenic patient had polymicrobial bacteremia. Intravascular catheters were the most common source of bacteremia (23.2%) in neutropenic patients, as compared with infections of the genito-urinary tract (45.1%) among non-neutropenic patients. In both groups, aerobic gram-positive cocci were the microorganisms most frequently isolated (71.6%). Anaerobic microorganisms showed an higher incidence in polymicrobial episodes than in monomicrobial episodes × 2 = 5.39 p = 0.02 OR = 2.97 95% CI (1.2-7.7).
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00145385
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  • 4
    Electronic Resource
    Electronic Resource
    Patterns of recovery phase infection after autologous blood progenitor cell transplantation in patients with malignancies (1995)
    Springer
    European journal of clinical microbiology & infectious diseases 14 (1995), S. 552-556 
    Details
    ISSN: 1435-4373
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Recovery phase infection patterns in 55 patients who had undergone autologous blood progenitor cell transplantation (ABPCT) were evaluated retrospectively. The results were compared to those obtained in a group of 41 patients who received autologous bone marrow transplantation (ABMT). Fever related to documented or suspected infection developed in 38 of 55 patients in the ABPCT group and in 37 of 41 in the ABMT group (p〈0.05). The percentages of patients with positive blood cultures did not differ significantly (ABPCT, 8/55 vs. ABMT, 8/41, p〉0.05). However, fewer acquired systemic fungal infections (1/55 vs. 5/41, p〈0.05) as well as fewer days of antibiotic usage were observed in the ABPCT group.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02113440
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  • 5
    Electronic Resource
    Electronic Resource
    Cutaneous Aspergillosis in Patients with Haematological Malignancies (2000)
    Springer
    European journal of clinical microbiology & infectious diseases 19 (2000), S. 362-365 
    Details
    ISSN: 1435-4373
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  The aim of the present study was to evaluate skin infections caused by Aspergillus in patients with haematological malignancies. Fifteen cases of cutaneous aspergillosis are reported, 12 of which occurred among 4448 consecutive patients with acute leukaemia. Cutaneous involvement occurred in 4% of patients with documented Aspergillus infection. Primary cutaneous aspergillosis was diagnosed in five cases. Infection was fatal in 11 of 15 cases; the absence of additional sites of infection other than cutis at presentation appeared to be the only factor related to a favourable outcome.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s100960050495
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    Paper (German National Licenses)
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  • 6
    Electronic Resource
    Electronic Resource
    Effect of the Current Antimicrobial Therapeutic Strategy on Fungal Colonization in Patients with Hematologic Malignancies (1996)
    Springer
    Current microbiology 33 (1996), S. 118-122 
    Details
    ISSN: 1432-0991
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract. A “quasi-experimental” trial was carried out to investigate the effect of three antimicrobial regimens on oral and fecal yeast colonization in patients with hematologic malignancies. Fifty-four patients received ciprofloxacin and oral amphotericin B (group 1); 45 received ceftazidime, amikacin, vancomycin, and oral amphotericin B (group 2); and 30 received ceftazidime, amikacin, vancomycin, and intravenous amphotericin B (group 3). The oral yeast isolation rate showed a decrease in group 1 (from 59.3% to 40.7%) and group 3 (from 56.7% to 46.7%), and a marked increase in group 2 (from 51.1% to 84.4%). All the groups showed a reduction in their fecal yeast isolation rate. An overgrowth of Candida parapsilosis, C. krusei, and C. tropicalis was observed in all the groups, but it was much higher in group 2. Our findings provide evidence that ceftazidime, amikacin, and vancomycin, given with oral amphotericin B, induce an overgrowth/persistence of Candida species in the mouth and gut, which might be attributable to inclusion of vancomycin. Treatment with intravenous amphotericin B has at least the capacity of counterbalancing yeast proliferation induced by that antibacterial regimen.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002849900085
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    Paper (German National Licenses)
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