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  • 1
    Electronic Resource
    Electronic Resource
    Near Infrared Spectroscopy in the Diagnosis of Alzheimer's Disease (1996)
    Oxford, UK : Blackwell Publishing Ltd
    Annals of the New York Academy of Sciences 777 (1996), S. 0 
    Details
    ISSN: 1749-6632
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Natural Sciences in General
    Notes: Near infrared spectroscopy (NIRS) is a new technique that permits noninvasive monitoring of cerebral blood and tissue oxygenation. Recently, we and others have shown that NIRS measurements are sensitive enough to follow changes in cerebral hemoglobin oxygenation due to activation of brain function. Based on these findings we have assessed the influence of aging as well as the influence of neurodegeneration on cerebral hemoglobin oxygenation during mental work. The typical NIRS pattern in young healthy subjects while performing calculation tasks measured in the frontal cortex were increases in oxygenated hemoglobin [HbO2] and total hemoglobin [HbT] while reduced hemoglobin [HbR] decreased. Elderly healthy subjects showed a significant lower mean increase in [HbO2] and [HbT] levels. Regression analysis revealed an age-dependent decline in activation-induced local increase of [HbO2] as well as [HbT]. Furthermore, we monitored changes in cerebral hemoglobin oxygenation in the frontal cortex while patients with probable Alzheimer's disease (AD) performed cognitive tasks. Whereas elderly healthy subjects (as well as patients with major depression, age-associated memory impairments or vascular dementia) again showed clear increases in the local concentrations of [HbO2] and [HbT] during brain activation, AD patients showed significant decreases compared to the baseline levels in both variables that were most pronounced in the parietal cortex. To clarify whether the different patterns in cerebral hemoglobin oxygenation during cognitive activation were due to an altered functional brain organization in AD or to alterations in the cerebrovascular response to neuronal activation, we are currently performing simultaneous NIRS and (015-H20-)PET measurements during performance of a cognitive task (Stroop test). Our finding of a regional reduced oxygen supply during activation of brain function may be of relevance to the development and the time course of neurodegeneration.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1749-6632.1996.tb34397.x
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  • 2
    Electronic Resource
    Electronic Resource
    Subsurface Microscopical visualization of brain tissue in vivo: Present, problems and prospects
    Amsterdam : Elsevier
    Micron 24 (1993), S. 611-622 
    Details
    ISSN: 0968-4328
    Keywords: Cerebral microcirculation ; confocal microscopy ; cranial window ; fluorescent dyes ; intracellular ion concentrations ; ischemia ; laser ; leukocytes ; meningitis ; opto-acoustic device ; slit scanning
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Electrical Engineering, Measurement and Control Technology , Natural Sciences in General
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0968-4328(93)90039-4
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  • 3
    Electronic Resource
    Electronic Resource
    Optical imaging of brain function and metabolism (1992)
    Springer
    Journal of neurology 239 (1992), S. 359-360 
    Details
    ISSN: 1432-1459
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Optical techniques already have an important place in experimental in vivo studies of the brain. New techniques to study micro circulatory and metabolic events in vivo will play an important role in basic stroke research. Functional studies are rapidly improving our knowledge of the functional architecture of the visual cortex. For studies of the human brain the confluence of interest and activity in MRI, PET, ballistic and diffusive wave spectroscopy opens new fields of anatomical, physiological, biochemical and functional studies. Similar to the introduction of the morphologically oriented computed tomography and magnetic resonance imaging, these new approaches may have a profound impact on clinical and experimental neurology in the future. The proceedings of this symposium will be published within the seriesAdvances in Experimental Medicine and Biology, Plenum Press, London New York, fall 1992.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00812149
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