ISSN:
1432-1912
Keywords:
Locus coeruleus
;
Neuronal firing rate
;
Central β1- and β2-adrenoceptors
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary Acute i.v. administration of the non-selective β-adrenoceptor antagonist dl-propranolol given in incremental doses (〈40 mg/kg) did not affect the firing rate of locus coeruleus (LC) neurones in the rat, as revealed by single cell recording techniques. Furthermore, no effect was seen 4 h after a single i.p. dose of this β-blocker (10 mg/kg). However, repeated treatment with dl-propranolol (1, 5, 10 or 20 mg/kg i.p., twice daily for 4 days) produced a significant, dose-dependent decrease of the average LC neuronal firing rate in comparison to controls. The dextro isomer of propranolol, which has negligible β-blocking activity but the same local anaesthetic potency as the racemate, had no corresponding effect. The non-selective β-adrenoceptor antagonist sotalol, which is one of the most hydrophilic β-blockers, had much less inhibitory effect on LC neurones than dl-propranolol. The β1-selective antagonist metoprolol did not change the firing of noradrenergic neurones in the LC after similar treatment for 4 days. However, when the rats were subjected to oral treatment for 28 days, metoprolol was found to produce a slight inhibitory effect although much less than dl-propranolol. In view of these findings we propose a stimulatory and mainly β2-adrenoceptor-mediated control mechanism for the noradrencrgic neurones in the LC. This mechanism seems to be characterized by a delayed responsiveness.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00506252
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