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  • 1
    Electronic Resource
    Electronic Resource
    2- and 6-Methyl-1,4-naphthoquinone derivatives as potential bioreductive alkylating agents (1982)
    s.l. : American Chemical Society
    Journal of medicinal chemistry 25 (1982), S. 730-735 
    Details
    ISSN: 1520-4804
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/jm00348a023
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  • 2
    Electronic Resource
    Electronic Resource
    Attenuation of cold-induced apoptosis by exogenous melatonin in carrot suspension cells: the possible involvement of polyamines (2004)
    Oxford, UK : Munksgaard International Publishers
    Journal of pineal research 36 (2004), S. 0 
    Details
    ISSN: 1600-079X
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Abstract:  Pretreatment with 43 nm (10 ng/mL) to 86 nm melatonin for 5 days significantly attenuated cold-induced apoptosis in carrot suspension cells (Daucus carota L.) as evidenced by the TUNEL procedure, DNA fragmentation and the morphological changes revealed by electronic microscopy observations. The antiapoptotic effect of melatonin was initially thought to be a result of its antioxidant actions. In our study, however, reactive oxygen species (ROS) generation remained unaffected by melatonin treatment, suggesting that melatonin plays its protective role not related to its direct ROS scavenger. At the same time, notable increases in putrescine and spermidine levels were observed in melatonin-treated cells, which may be responsible for the alleviation of the cold-induced apoptosis. The possible involvement of polyamines in the antiapoptotic effect of melatonin was further confirmed by the inhibitory effect of exogenous polyamines on apoptosis as displayed by the DNA laddering assay.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1600-079X.2003.00106.x
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  • 3
    Electronic Resource
    Electronic Resource
    Rejuvenation of degenerative thymus by oral melatonin administration and the antagonistic action of melatonin against hydroxyl radical-induced apoptosis of cultured thymocytes in mice (2001)
    Copenhagen : Munksgaard International Publishers
    Journal of pineal research 31 (2001), S. 0 
    Details
    ISSN: 1600-079X
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The effect of melatonin on age-related thymic involution and apoptosis induced by hydroxyl radicals (·OH) in mouse thymocyte cultures was investigated. Exogenous melatonin was administered in the drinking water (15 μg/mL) of 7-month-old male Balb/c mice for 40 consecutive days. Our results show that melatonin distinctly reversed the age-related thymic involution as revealed by the notable increase of cellular density, particularly the number of thymocytes, percentage of thymocytes at G2+S phases and the younger morphological appearance as a whole when compared with control animals. More strikingly, the recovery of these morphometric parameters were maintained for 30 days after the termination of melatonin administration suggesting that the re-established homeostasis by melatonin may last for a longer time. At the same time, when primary culture of thymocytes was preincubated with 200 μM melatonin before their exposure to hydroxyl radicals (·OH) generated by Fe2+-mediated Fenton reaction, apoptotic cell death induced by ·OH was almost completely prevented as determined by both flow cytometric analysis and the TUNEL assay. DNA laddering assay also documented the inhibition of thymocyte apoptosis by melatonin. Furthermore, we found that the ·OH-induced increment of caspase-3 activity in thymocytes was completely abolished by melatonin preincubation. Taken together, our study indicates that in addition to other mechanisms, melatonin may also directly act as an antioxidant via attenuating apoptotic thymocyte death caused by free radicals and stimulates thymocyte proliferation in thymus and thus to rejuvenate the degenerative organ.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1034/j.1600-079X.2001.310304.x
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  • 4
    Electronic Resource
    Electronic Resource
    Acetyl-CoA decarbonylase/synthase complex from Archaeoglobus fulgidus (1998)
    Springer
    Archives of microbiology 169 (1998), S. 525-529 
    Details
    ISSN: 1432-072X
    Keywords: Key words Acetyl-CoA ; Sarcinapterin ; Methanopterin ; Multienzyme complex ; Ferredoxin ; Archaeoglobus ; fulgidus ; Methanosarcina
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract The acetyl-CoA decarbonylase/synthase (ACDS) multienzyme complex catalyzes the reversible cleavage and synthesis of acetyl-CoA in methanogens. This report of the enzyme complex in Archaeoglobus fulgidus demonstrates the existence of a functional ACDS complex in an organism that is not a methanogen. The A. fulgidus enzyme complex contained five subunits of 89, 72, 50, 49.5, and 18.5 kDa, and it catalyzed the overall synthesis of acetyl-CoA according to the following reaction: w CO2 + 2 Fdred(Fe2+) + 2 H+ + CH3– H4SPt + CoA ⇌ acetyl-CoA + H4SPt + 2 Fdox(Fe3+) + H2O where Fd is ferredoxin, and CH3–H4SPt and H4SPt denote N 5-methyl-tetrahydrosarcinapterin and tetrahydrosarcinapterin, respectively.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002030050606
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  • 5
    Electronic Resource
    Electronic Resource
    Effect of ethrel on apoptosis in carrot protoplasts (1999)
    Springer
    Plant growth regulation 27 (1999), S. 119-123 
    Details
    ISSN: 1573-5087
    Keywords: apoptosis ; carrot protoplast ; DNA ladder ; ethrel ; ethylene ; nucleus condensation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition
    Notes: Abstract In recent years, apoptosis has been reported to exist in plants during normal development and in response to stress. However, little is known about the relation of hormones to this form of programmed cell death. Here, we report examination of characteristics of apoptosis in carrot protoplasts induced by ethylene evolved from ethrel (2-chloroethylphosphonic acid). Nucleus condensation and DNA ladders were observed, and neutral comet assay, which detects DNA cleavage, also provided evidence that ethrel treatment resulted in nuclear DNA fragmentation. Strikingly, a close correlation between the incidence of DNA comets and the percentage of apoptotic protoplasts was shown in ethrel-treated carrot protoplasts. In conclusion, this study demonstrated that ethylene is an active inducer of apoptosis in carrot protoplasts, and that ethylene-induced plant cell death showed characteristics similar to those of apoptosis in animals.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1006105101813
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  • 6
    Electronic Resource
    Electronic Resource
    Stimulation of ethylene production by catecholamines and phenylethylamine in potato cell suspension cultures (1993)
    Springer
    Plant growth regulation 12 (1993), S. 219-222 
    Details
    ISSN: 1573-5087
    Keywords: ethylene ; catecholamine ; dopamine ; norepinephrine ; epinephrine ; phenylethylamine
    Source: Springer Online Journal Archives 1860-2000
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition
    Notes: Abstract The catecholamines (50 μM dopamine, 50 μM norepinephrine and 100 μM epinephrine) and phenylethylamine (200 μM) were found to stimulate ethylene production in potato suspension cultures. When 100 μM amino-oxyacetic acid was added together with epinephrine, ethylene release returned to control levels. The endogenous 1-aminocyclopropane-1-carboxylic acid levels were increased in parallel with the release of ethylene, suggesting that the observed effect probably occurs via regulation of aCC synthase. Our results suggest that there is a link between these naturally occurring monoamines and ethylene in plants.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00027201
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