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  • 1
    Electronic Resource
    Electronic Resource
    Absolute and relative activities of platinum-complexes on human tumors as evaluated by an antimetabolic in vitro assay (1987)
    Springer
    Investigational new drugs 5 (1987), S. 245-250 
    Details
    ISSN: 1573-0646
    Keywords: cisplatin ; carboplatin ; iproplatin ; antimetabolic assay
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Abstract An in vitro assay, which evaluates drug effect on 3H-thymidine incorporation, was used to investigate the absolute and relative activities of cisplatin (DDP), carboplatin (CBDCA) and iproplatin (CHIP) on 317 specimens from untreated tumors, including breast and ovarian cancers and malignant melanomas. Similar activities were generally observed for DDP and CHIP, whereas CBDCA exhibited a lower, although not significantly different cytotoxicity on breast and ovarian cancers. The relative activities of Platinum analogues were analyzed on 239 two-way drug sensitivity comparisons. The overall agreement rates ranged from 80.2 to 83.9% for the different comparisons. High coresistance, from 61.1 to 93.8%, was observed for all the comparisons, regardless of the tumor type. Cosensitivity rates were poor for breast and ovarian cancers, from 0 to 37.5%, whereas for melanomas an association in sensitivity was observed in 80% of the cases.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00175294
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Comparing core needle to surgical biopsies in breast cancer for cell kinetic and ploidy studies (1991)
    Springer
    Breast cancer research and treatment 19 (1991), S. 33-37 
    Details
    ISSN: 1573-7217
    Keywords: breast cancer ; cell proliferation ; core needle biopsy ; ploidy ; thymidine labeling index
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The evaluability and reliability of proliferative activity (expressed as3H-thymidine labeling index,3H-TdR LI) and ploidy determinations on core needle biopsies were compared with those obtained on surgical material from the same breast cancers. The evaluability of3H-TdR LI on core needle biopsies was markedly lower than that on surgical material (53% vs 100%), and the association between3H-TdR LI values in the 16 cases with both evaluable determinations was poor (rs=0.45). Conversely, determinations of ploidy on core needle biopsy and surgical material provided superimposable results, in terms of evaluability (91% vs 100%) and reliability (rs=0.99). Further efforts are needed to improve sampling procedures for a reliable assessment of biological markers.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01975202
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Prognostic implication of labeling index versus estrogen receptors and tumor size in node-negative breast cancer (1986)
    Springer
    Breast cancer research and treatment 7 (1986), S. 161-169 
    Details
    ISSN: 1573-7217
    Keywords: labeling index ; prognosis ; node-negative breast cancer ; estrogen receptor ; survival
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The paper analyzes the relation among tumor size (T), estrogen receptor (ER) status, and labeling index (LI) and their relative merits in predicting the relapse-free (RFS) and overall survival (OS) in 215 node-negative women with primary breast cancer. All patients were subjected to Halsted or modified radical mastectomy; none received postoperative irradiation or systemic adjuvant therapy. The 5-year RFS was 75.3% and OS 89.0% When singly tested, LI and ER were able to significantly predict RFS and OS. In contrast, T influenced only RFS but not OS. The multivariate analysis showed that, in the presence of the two other variables, only LI retained its prognostic significance both for time to relapse (p = 0.0044) and survival (p = 0.035). From the present findings, LI appears to be a new important prognostic variable in the selection of high risk patients for whom adjuvant systemic therapy should perhaps be part of their primary treatment.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01806246
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  • 4
    Electronic Resource
    Electronic Resource
    Relationship among estrogen receptors, proliferative activity and menopausal status in breast cancer (1981)
    Springer
    Breast cancer research and treatment 1 (1981), S. 253-262 
    Details
    ISSN: 1573-7217
    Keywords: labeling index ; estrogen receptors ; menopausal status
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Kinetic and estrogen receptor (ER) determinations were performed on 357 primary breast cancers. The proliferative activity of the cell population was determined by the autoradiographic technique and expressed as [3H]thymidine labeling index (LI); the ER status was assessed by the absorption charcoal technique. From the overall analysis of the relationship between proliferative activity and ER status, by using the median LI value as cutoff of low and high proliferating tumors, a correlation between ER + status and low proliferative activity and between ER-status and high proliferative activity was observed in 64% of the cases. Menopausal status proved to be an important determinant of kinetic and ER features. In fact, the proliferative activity was always higher in ER − tumors than in ER + tumors within the same menopausal group, and a decrease in proliferative activity was observed from premenopause to postmenopause within ER + and ER − tumors. The analysis of the relation between ER levels and proliferative activity in ER + tumors also evidenced three main ER/LI clusters significantly related to premenopause, paramenopause and postmenopause. A particular indication of nodal involvement was evidenced for a cluster of tumors with low ER levels and high LI from postmenopausal patients. The three different, previously proposed kinetic groups of potential relevance for prognostic and therapeutic purposes were confirmed and more precisely defined by considering not only premenopause and postmenopause but also paramenopause.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01806265
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  • 5
    Electronic Resource
    Electronic Resource
    Effect of menstrual phase on cell proliferative rate of breast cancer (1998)
    Springer
    Breast cancer research and treatment 48 (1998), S. 93-94 
    Details
    ISSN: 1573-7217
    Keywords: cell proliferation ; cyclic fluctuation ; menstrual phase ; premenopause ; time of surgery
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1005917412174
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    Paper (German National Licenses)
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  • 6
    Electronic Resource
    Electronic Resource
    Quantitative immunohistochemical determination of cathepsin-D and its relation with other variables (1993)
    Springer
    Breast cancer research and treatment 26 (1993), S. 7-13 
    Details
    ISSN: 1573-7217
    Keywords: Cathepsin D ; hormone receptors ; immunohistochemistry ; proliferative activity
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The expression of cathepsin D was evaluated by immunohistochemistry on histologic sections from formalinfixed samples in a series of 436 primary breast cancers. The fraction of cathepsin D-positive tumor cells was not related to tumor size or hormone receptor status, and only weakly related to proliferative activity, evaluated as the3H-thymidine labeling index. Conversely, a higher fraction of positive cells was observed in nodepositive than in node-negative tumors (p = 0.05). A matched comparison between immunohistochemical and immunoradiometric results on individual tumors was carried out on 100 cases and showed a significant association but with a correlation coefficient of 0.46. The agreement of results from the two assays was higher in ER− than in ER+ tumors, which sometimes showed an immunostaining limited to macrophages and normal epithelial cells. In situ evaluation has the main advantage of being specifically applicable to detection in tumor cells and allows the simultaneous determination of different biologic aspects for a more complete understanding of breast cancer biology.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00682695
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    Paper (German National Licenses)
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