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  • 1
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Annals of the New York Academy of Sciences 746 (1994), S. 0 
    ISSN: 1749-6632
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Natural Sciences in General
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Journal of neuroendocrinology 5 (1993), S. 0 
    ISSN: 1365-2826
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The authors have identified two types of hippocampal cDNAs for the rat mineralocorticoid receptor (rMR) which are identical in the protein coding domain but differ in their 5′-untranslated sequences. One of these clones encodes a novel type of rMR cDNA with a high homology to a previously described human MR cDNA isolated from the kidney. A genomic clone containing the 5′-end of the rat MR gene was isolated. The 12.7 kb genomic region contains the 5′-coding exon with the translational start site and contiguous DNA sequences encoding the N-terminal domain of the rMR. A 240 bp region homologous to the 5′-untranslated sequences of the novel rMR cDNA was located 5.2 kb upstream the protein coding region. Characterization of the nucleotide sequence preceding this exon revealed several features characteristic for promoters of so-called ‘housekeeping genes'. The sequence analyzed is 635 bp in length, is rich in G + C nucleotides (63%) and lacks TATA or CAAT regulatory elements. It contains three putative binding sites for transcription factor Sp1 as well as several short sequences that are similar to known cis-acting enhancers or binding sites for transcription factors. In transient transfection experiments employing the luciferase reporter gene and the CV1 cell line this region exhibits substantial promoter activity. These experiments demonstrate that expression of the rat MR gene in the hippocampus results in at least two transcripts with different 5′-untranslated exons. This sequence information together with the nucleotide sequences upstream of one of the exons, which were shown to encode a functional promoter, provide a valuable tool to elucidate the mechanisms involved in the tissue-specific regulation of the rat MR gene.
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 1437-3262
    Source: Springer Online Journal Archives 1860-2000
    Topics: Geosciences
    Description / Table of Contents: Abstract Analysis of extended plutons in the Coast Range of North Chile between 25°30′ and 26°35′ led to the recognition of a complex magmatic and structural evolution from the Upper Paleozoic to the Tertiary. The ascension of the intrusive bodies is dictated by deep-seated block tectonics. Generally the chemistry changes from S-type magmas in the Paleozoic to I-type magmas in the Mesozoic and Cainozoic. This is accompanied by a change in the structural geology of the continental margin which we present in six hypothetic phases (Devonian-Tertiary). We are only at the beginning of an encompassing synthesis of the genesis of the Andean orogen.
    Abstract: Resumen El análisis de extensos plutones en la Cordillera de la Costa/Norte de Chile entre lat. 25°30′ y 26°35′ S ha revelado un complejo desarrollo magmático-estructural entre el Paleozoico Superior y el Terciario. La ascensión de los cuerpos intrusivos está determinado por una profunda tectónica vertical de bloques. En general el quimismo cambia de magmas de tipo “S” en el Paleozoico hacia magmas de tipo “I” en el Mesozoico y Cenozoico. Este cambio está acompañado por una modificación de la estructura geológica del borde continental, que describimos en seis fases hipotéticas (Devónico-Terciario). Nos encontramos tan sólo en el comienzo de una amplia síntesis de la génesis del orógeno de los Andes.
    Notes: Zusammenfassung Die Analyse ausgedehnter Plutone in der Küstenkordillere Nordchiles zwischen Lat. 25°30′ und 26°35′ S ergab eine komplexe magmatisch-strukturelle Entwicklung zwischen dem jüngeren Paläozoikum und dem Tertiär. Der Aufstieg der Intrusivkörper wird von einer tiefgreifenden vertikalen Schollentektonik diktiert. Allgemein wechselt der Chemismus von S-Typ-Magmen im Paläozoikum zu I-Typ-Magmen im Mesozoikum und Känozoikum. Dieser Wechsel wird von einer strukturgeologischen Veränderung des Kontinentalrandes begleitet, die wir in sechs hypothetischen Phasen (Devon-Tertiär) darstellen. Wir stehen erst am Beginn einer umfassenden Synthese über die Genese des Anden-Orogens.
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Springer
    International journal of earth sciences 70 (1981), S. 1054-1076 
    ISSN: 1437-3262
    Source: Springer Online Journal Archives 1860-2000
    Topics: Geosciences
    Description / Table of Contents: Abstract Extended deep plutons of the Chilean Coast-Range can, according to their composition, age and spatial distribution, be assigned to the following three Superunits, each of which represents a closed magmatic cycle. Albayay-Superunit approximately 300-200 m. a. Cifuncho-Superunit approximately 190-130 m. a. Esmeralda-Superunit less than 130 m. a. Structurally we distinguished five large batholithic complexes, which are tectonically displaced along vertical fault-planes. The petrographie composition ranges from gabbronoritic through dioritic up to granitic rocks with predominance of granitoids. Methodical investigation led beyond the explanation of the origin of the magma, and opened the way for new geogynamic interpretations. We postulate a model of repeated crustal thickening caused by continental collision, which is opposed to the schematic plate-tectonics model.
    Abstract: Resumen En la Cordillera de la Costa del Norte de Chile existen extensos cuerpos intrusivos que se queden asignar, sobre la base de su composición, edad y distribución espacial, a las tres Superunidades siguientes, las que a su vez corresponden a ciclos magmáticos completos. Superunidad-Albayay approximadamente 300-200 m.a. Superunidad-Cifuncho approximadamente 190-130 m.a. Superunidad-Esmeralda más jóvenque 130 m.a. Estructuralmente hemos distinguido cinco complejos batoliticos mayores recortados por una tectónica de fallas verticales. La compositión petrográfica va desde rocas gabronoríticas hasta graníticas pasando por las dioríticas, con predominio de granitoides. El análisis metódico de los datos obtenidos orientado a la petrogénesis de estos cuerpos dió lugar a nuevas interpretaciones geodinámicas. Postulamos un modelo de fases sucesivas de acumulación cortical mediante colisión continental, el cual se opone al esquemático modelo de la Tectónica de Placas.
    Notes: Zusammenfassung In der Küstenkordillere Nordchiles lassen sich ausgedehnte Tiefengesteinskörper nach Stoffbestand, Alter und rÄumlicher Verteilung folgenden drei Superunits zuordnen, die jeweils einem abgeschlossenen magmatischen Zyklus entsprechen. Albayay-Superunit ca. 300-200 m. a. Cifuncho-Superunit ca. 190-130 m. a. Esmeralda-Superunit jünger als 130 m. a. Strukturell haben wir fünf grö\ere, durch Tektonik entlang vertikaler Brüche zerlegte Baholith-Komplexe ausgeschieden. Die petrologische Zusammensetzung reicht von gabbro-noritischen über dioritische bis zu granitischen Gesteinen, wobei der Schwerpunkt bei den Granitoiden liegt. Die methodische Untersuchung führte über die KlÄrung der Magmengenese hinaus und eröffnete den Zugang zu neuen geodynamischen Vorstellungen. Wir postulieren ein Modell einer mehrphasigen Krustenverdickung durch kontinentale Kollision, das im Gegensatz zu dem schematischen Modell der Plattentektonik steht.
    Type of Medium: Electronic Resource
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  • 5
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Hormone binding and localization of the c-erb-A protein suggest that it is a receptor for thyroid hormone, a nuclear protein that binds to DNA and activates transcription. In contrast, the product of the viral oncogene v-erb-A is defective in binding the hormone but is still located in the ...
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    [s.l.] : Nature Publishing Group
    Nature 339 (1989), S. 593-597 
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] The thyroid-hormone receptor can, in the absence of its ligand, suppress activity of a responsive promoter. Addition of thyroid hormone, however, results in the stimulation of expression. The oncogenic derivative of the thyroid-hormone receptor, v-erbA, acts as a constitutive represser and, when ...
    Type of Medium: Electronic Resource
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  • 7
    Electronic Resource
    Electronic Resource
    New York, N.Y. : Wiley-Blackwell
    Journal of Cellular Biochemistry 57 (1995), S. 465-478 
    ISSN: 0730-2312
    Keywords: steroid receptors ; C-terminal domain ; DNA binding domain ; transcription ; nuclear localization ; nuclear matrix ; nuclear matrix acceptors ; interaction ; disulfide bridges ; Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Chemistry and Pharmacology , Medicine
    Notes: Steroid receptors have been reported to bind to the nuclear matrix. The nuclear matrix is operationally defined as the residual nuclear structure that remains after extraction of most of the chromatin and all soluble and loosely bound componnets. To obtain insight in the molecular mechanism of the interaction of steroid receptors with the nuclear matrix, we studied the binding of several deletion mutants of the human androgen receptor (hAR) and the human glucocorticoid receptor (hGR) to the nuclear matrix. Receptor binding was tested for two different nuclear matrix preparations: complete matrices, in which most matrix proteins are retained during the isolation procedure, and depleted matrices, which consist of only a subset of these proteins. The results show that the C-terminal domain of the hAR binds tightly to both depleted and complete matrices. In addition, at least one other domain of the hAR binds to complete matrices but not to depleted matrices. In contrast to the hAR, the hGR binds only to complete matrices. For this interaction both the DNA-binding domain and the C-terminal domain of the hGR are required, whereas the N-terminal domain is not. We conclude that specific protein domains of the hAR and the hGR are involved in binding to the nuclear matrix. In addition, our results indicate that the hAR and the hGR are attached to the nuclear matrix through different molecular interactions.
    Additional Material: 6 Ill.
    Type of Medium: Electronic Resource
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