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  • 1
    Electronic Resource
    Electronic Resource
    Salmonella infections in a cancer center (1994)
    Springer
    Supportive care in cancer 2 (1994), S. 116-122 
    Details
    ISSN: 1433-7339
    Keywords: Salmonella infections ; Cancer and infection ; Bacteremia
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Data concerning 40 patients hospitalized in a cancer center andSalmonella infection were analyzed. Hematological malignancy was present in 24 patients (60%) and solid tumor in 14 patients (35%). Among the predisposing factors, antineoplastic chemotherapy was the most frequent (60%) followed by antacid use (47.5%), corticosteroids (37.5%), granulocytopenia below 500 neutrophils/μl (15%), surgery (10%) and splenectomy (2.5%). Bacteremia was the most frequent clinical syndrome accounting for 42.5% of the patients. Focal infection, enteritis and carrier state accounted for the remaining 30%, 20% and 7.5% respectively.Salmonella typhimurium andS. dublin represented 65% of the isolates, with clear association between serotypedublin and bacteremia. AllS. dublin isolates were resistant to chloramphenicol. Amongdublin andtyphimurium serotypes, 20% the isolates were resistant to the traditional antibiotics used in salmonellosis (ampicillin, chloramphenicol, cotrimoxazole). All strains were susceptible in vitro to cephalosporins. The frequency of relapse was 15% and the overall mortality (within 30 days) attributed toSalmonella infection was 15%.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00572093
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  • 2
    Electronic Resource
    Electronic Resource
    Anaerobic bacteremia in a cancer center (1993)
    Springer
    Supportive care in cancer 1 (1993), S. 250-255 
    Details
    ISSN: 1433-7339
    Keywords: Anaerobes ; Bacteremia ; Cancer ; Bacteroides ; Clostridium
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Seventy-five episodes of clinically relevant anaerobic bacterial bacteremia observed in cancer patients were reviewed. Gastrointestinal (22.7%), hematological (22.7%) and female genital tract (18.6%) cancers were the most common underlying malignant diseases. Among 84 strains of strict anaerobic bacteria recovered in the 75 patients, gram-negative rods were isolated in 49 patients (58.3%), gram-positive rods in 29 patients (34.5%) and gram-positive cocci in 6 patients (8%). Bacteroides spp. and Clostridium spp. were the most frequent pathogens (85.7%). Twenty-one episodes of bacteremia were polymicrobial, aerobic gram-positive cocci being the most frequently associated pathogens. When identified, the primary sites were the gastrointestinal tract (40%), the female genital tract (17.3%), skin and soft tissue (14.6%), the oropharynx (12%) and the lower respiratory tract (6.7%). The source remained unknown in 7 cases (9.3%). The overall survival (evaluated 10 days after the occurrence of bacteremia) was 82.5%. There was no difference in mortality between patients with monomicrobial and polymicrobial bacteremia. Pulmonary complications were more frequent in patients with fatal outcome in comparison to patients who survived. The mortality rate of the patients adequately treated was 10.3% compared to 41% for the patients not treated or treated inadequately (P=0.016, X2).
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00366044
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  • 3
    Electronic Resource
    Electronic Resource
    A prospective, randomized study of pefloxacin versus teicoplanin in the treatment of gram-positive coccal infections in cancer patients: early termination due to emergence of resistance to fluoroquinolones (1994)
    Springer
    Supportive care in cancer 2 (1994), S. 191-196 
    Details
    ISSN: 1433-7339
    Keywords: Pefloxacin versus teicoplanin ; Gram-positive infections ; Antibiotic resistance ; Infections in cancer patients
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract A randomized prospective study comparing pefloxacin to teicoplanin in the treatment of gram-positive infections in cancer patients was prematurely terminated because of the emergence of pefloxacin resistance associated with oxacillin resistance in Staphylococcus aureus and coagulase-negative staphylococci. Among 56 patients evaluated for efficacy (26 pefloxacin and 30 teicoplanin) and infected with bacteria susceptible to both antibiotics, the clinical cure and eradication rates were similar for pefloxacin (80.5% and 77.3% respectively) and teicoplanin (66.6% and 52.2% respectively). The relapse rates (15% and 10% for pefloxacin and teicoplanin respectively) and the overall mortalities within 1 month (42% and 31%) were similar.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00417480
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  • 4
    Electronic Resource
    Electronic Resource
    Pneumococcal bacteremia in cancer patients (1988)
    Springer
    European journal of epidemiology 4 (1988), S. 242-245 
    Details
    ISSN: 1573-7284
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Twenty-eight episodes of Streptococcus pneumoniae bacteremia occurring in 27 cancer patients hospitalized in the Institut Jules Bordet between July 1979 and April 1985 were reviewed. Ten patients had hematological malignancies and 17 had solid tumors (in 7 cases, of the lung). Forty-four per cent of the patients were neutropenic (〈1000/μl) and 36% of the patients were in septic shock. In 36% of the patients, no clinical source of S. pneumoniae bacteremia could be found. Seventy-nine (21% patients) received empirical antibiotic treatment containing a beta-lactam. Two patients who did not receive any empirical treatment died within 12 hours. Overall, 11/27 patients died within the first week, and 8/27 died within the first three days. Mortality in neutropenic patients was not different from that in non-neutropenic patients. In comparison with a similar study performed previously in our institution, there was no difference in incidence, type of patient, source of bacteremia, or mortality.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00144760
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  • 5
    Electronic Resource
    Electronic Resource
    Incidence and significance ofclostridium difficile in hospitalized cancer patients (1988)
    Springer
    European journal of clinical microbiology & infectious diseases 7 (1988), S. 274-278 
    Details
    ISSN: 1435-4373
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The aim of the study was to assess the incidence and clinical significance ofClostridium difficile in patients in our cancer center. Over a period of seven consecutive months, 557 stools samples obtained from 156 hospitalized cancer patients (37 leukemic patients receiving oral antimicrobial prophylaxis and 119 patients from whom a stool sample was sent to the laboratory) were analyzed for the presence ofClostridium difficile. Clostridium difficile and/or its toxin was recovered from 13 (35 %) of the 37 patients receiving oral antimicrobial prophylaxis, and from 15 (12 %) of the other 119 patients (p〈0.05). Isolation ofClostridium difficile was associated with diarrhoea in 13 (46 %) of 28 patients but specific treatment was initiated only in 7 (25 %) of the 28 patients in whomClostridium difficile was isolated. The wide distribution of the serotypes identified in our patients does not suggest an epidemic situation in our hospital.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01963101
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  • 6
    Electronic Resource
    Electronic Resource
    Nosocomial bacteremia caused byBacillus species (1988)
    Springer
    European journal of clinical microbiology & infectious diseases 7 (1988), S. 783-785 
    Details
    ISSN: 1435-4373
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract During a six year period, 11 cases of bacteremia caused byBacillus spp. were observed corresponding to 1 % of all bacteremic episodes in our hospital. Most patients had cancer as underlying disease. All cases of positive blood cultures were associated with a clinical syndrome compatible with sepsis including high fever. None of the subsequent deaths could be related to the bacteremia caused byBacillus spp. Four of eight cases ofBacillus subtilis bacteremia were associated with the absorption of an oral preparation containingBacillus subtilis spores, which was administered empirically in some units of the hospital to reduce what was considered to be tubefeeding related diarrhea.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01975049
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  • 7
    Electronic Resource
    Electronic Resource
    Effect of high doses of cefoperazone on stool flora (1983)
    Springer
    European journal of clinical microbiology & infectious diseases 2 (1983), S. 607-608 
    Details
    ISSN: 1435-4373
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02016580
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    Paper (German National Licenses)
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  • 8
    Electronic Resource
    Electronic Resource
    Susceptibility of gram-negative bacteria isolated from the blood of cancer patients (1982)
    Springer
    European journal of clinical microbiology & infectious diseases 1 (1982), S. 193-194 
    Details
    ISSN: 1435-4373
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02019622
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    Paper (German National Licenses)
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