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  • 1
    Electronic Resource
    Electronic Resource
    In vitro ADP-ribosylation of chromosomal proteins of the brain of developing rats (1986)
    Springer
    Molecular biology reports 11 (1986), S. 63-68 
    Details
    ISSN: 1573-4978
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract In vitro ADP-ribosylation of chromosomal protein and its modulation by spermine, 3-aminobenzamide (3-AB) and benzamide were studied by incubating the nuclei of cerebral hemisphere of 3-, 14- and 30-day old rats with 32P-NAD+. Histones get ADP-ribosylated more than the non-histone chromosomal (NHC) protein. H1 is the major target for ADP-ribosylation. Among the nucleosomal histones, H2B is ADP-ribosylated most. The other core histones also get ADP-ribosylated to a lesser extent. ADP-ribosylation of both histones and NHC proteins decreases during development. Spermine stimulates, whereas 3-AB and benzamide inhibit, 32P-ADP-ribose incorporation into histones and NHC proteins. These effects decrease with development. Mild digestion of chromatin by micrococcal nuclease (MNase), EcoRI, and AluI prior to ADP-ribosylation stimulates incorporation of 32P-ADP-ribose. The degree of stimulation decreases as development proceeds. Such alterations indicate progressive condensation of chromatin with development.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00364815
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  • 2
    Electronic Resource
    Electronic Resource
    Effect ofin vitro (ADP)ribosylation on transcription of the chromatin of the brain of developing rats (1987)
    Springer
    Molecular biology reports 12 (1987), S. 43-47 
    Details
    ISSN: 1573-4978
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract The template-engaged RNA polymerase II was assayed in the nuclei purified from the cerebral hemisphere of 3-, 14- and 30-day old rats. Its activity is the highest at 3-day and declines as development proceeds. Lower transcription at 30-day may either be due to a decrease in the active fraction of chromatin or to a decrease in the amount of RNA polymerase II that is active towards endogenous template, or both. The activity of RNA polymerase I (active in low salt) is also maximal at 3-day and declines as development proceeds. (ADP)ribosylation of chromatin depresses RNA synthesis. This may be due to inactivation of RNA polymerase itself by protein poly(ADP)ribosylation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00580649
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Developmental changes in the chromatin of the brain of the rat: analysis by nicktranslation (1986)
    Springer
    Molecular biology reports 11 (1986), S. 195-197 
    Details
    ISSN: 1573-4978
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract Nick translation of nuclei of the brain of 3- 14- and 30-day old rats was carried out following their digestion by DNase I. The incorporation of 3H-dTMP at 14- and 30-day is significantly lower than at 3-day. This may be due to a lower proportion of active chromatin (DNase I hypersensitive sites) and condensation of chromatin with progressive development. When nuclei were digested by EcoRI and then nick-translated, the incorporation of 3H-dTMP showed the same pattern. Since the EcoRI sites are believed to be randomly distributed, the overall conformation of chromatin including the DNase I sensitive sites seems to undergo increasing compaction with development.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00419596
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Blood coagulation and fibrinolysis in experimental hypercholesterolemic rats (1961)
    Springer
    Naturwissenschaften 48 (1961), S. 623-624 
    Details
    ISSN: 1432-1904
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology , Natural Sciences in General
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00591208
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    Paper (German National Licenses)
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  • 5
    Electronic Resource
    Electronic Resource
    Antibiotic principle from moringa pterygosperma (1954)
    Springer
    Naturwissenschaften 41 (1954), S. 66-66 
    Details
    ISSN: 1432-1904
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology , Natural Sciences in General
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00634183
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    Paper (German National Licenses)
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