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  • 1
    Electronic Resource
    Electronic Resource
    Response to bronchodilators in clinically stable 1-year-old patients with bronchopulmonary dysplasia (1997)
    Springer
    European journal of pediatrics 157 (1997), S. 75-79 
    Details
    ISSN: 1432-1076
    Keywords: Key words Bronchopulmonary dysplasia Bronchodilators ; Pulmonary function
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Bronchodilators are often used in the treatment of patients with bronchopulmonary dysplasia (BPD). However, few studies evaluate their efficacy in patients with stable disease beyond the newborn period. Therefore, pulmonary function was measured before and after aerosol treatment with salbutamol (0.25 ml Ventolin 0.5%) and subsequently after aerosol with ipratropium bromide (0.25 ml Atrovent 0.025%). Studies were performed at the corrected postnatal age of 52±2 weeks in 52 patients who had been ventilated after birth because of newborn lung disease. Twenty-two of these 52 patients had developed BPD. Pulmonary function was measured after sedation and using the PEDS system. Expiratory resistance (median 52.1 versus 39.1 cmH2O/l/s; P〈.008) and inspiratory resistance (median 42.5 vs 27.8 cmH2O/l/s; P〈.04) were significantly worse in BPD patients at the age of 1 year. Half of the BPD patients had a decrease in pulmonary resistance after salbutamol. However, there was no statistically significant decrease in pulmonary resistance after salbutamol or ipratropium in the BPD patients as a group. After salbutamol pulmonary resistance significantly worsened in the patients who did not develop BPD. Conclusion Although individual patients may benefit, routine administration of bron chodilators seems not warranted in stable BPD patients at the age of 1 year.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004310050771
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Primary ciliary dyskinesia: evolution of pulmonary function (1998)
    Springer
    European journal of pediatrics 157 (1998), S. 422-426 
    Details
    ISSN: 1432-1076
    Keywords: Key words Primary ciliary dyskinesia ; Lung function ; Bronchodilators
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Pulmonary function tests were obtained in 11 patients with primary ciliary dyskinesia. Their mean age was 15 years (range 6–32). Their pulmonary function was obstructive, with a vital capacity (mean ± SD) of 75% ± 20% predicted, a forced expiratory volume in 1s (FEV1) of 63% ± 20% predicted and a raised residual volume of 169% ± 50% predicted. After inhalation of 200 μg of salbutamol the mean change in FEV1 was +13.2% ± 9.6% of the baseline value. In the 10 oldest patients, lung function had been measured at regular intervals during 3–20 years. Interestingly, during childhood and adolescence the evolution was not unfavourable: vital capacity increased by 8% ± 20% and FEV1 remained stable (mean change 0.3% ± 12%). Only 2 patients had an unfavourable evolution. Conclusion At time of diagnosis, patients with primary ciliary dyskinesia have partially reversible obstructive airway disease. During regular follow up and therapy, there is no evidence of a further decline in lung function. Patients with associated immunodeficiency or important damage at the start of therapy may have a worse prognosis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004310050843
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Determination of the depth resolution of Auger electron spectroscopy depth profiles of anodic barrier oxide films on differently pretreated aluminium substrates (1994)
    Chichester [u.a.] : Wiley-Blackwell
    Surface and Interface Analysis 22 (1994), S. 175-180 
    Details
    ISSN: 0142-2421
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Physics
    Notes: The virtual interface width in AES sputter depth profiles of amorphous anodic oxide coatings on aluminium is investigated. Even when the physical film-substrate interface is relatively sharp, considerable deterioration of the depth resolution may be caused by sputter-induced roughness if sputtering conditions or the sample quality are not chosen properly. The effects of the oxide film thickness, choice of sputter angle and initial substrate roughness on the appearance of the interface width are investigated. A systematic study of the influence of Zalar rotation on the depth resolution is presented. It is concluded that long sputter times, due to film thickness or grazing sputter angles, and initial surface roughness cause a deterioration of the depth resolution. Zalar rotation generally improves the depth resolution for amorphous films, and is particularly indicated for the analysis of very rough samples. The sputter rate of amorphous films however, is insensitive to the use of Zalar rotation.
    Additional Material: 2 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/sia.740220139
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    Paper (German National Licenses)
    Fulltext
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