ISSN:
1434-193X
Keywords:
Corticium sp.
;
Steroids
;
Alkaloids
;
Secondary metabolites
;
Cytotoxic activity
;
Chemistry
;
General Chemistry
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
Notes:
-Five new steroidal alkaloids, plakinamines C (1) and D (2), and the related compounds 3-5 have been isolated from the Vanuatu sponge Corticium sp. Their structures have been elucidated by a detailed spectroscopic analysis, including 2D-HMBC and ROESY correlation experiments. The new compounds show significant in vitro cytotoxicity against human bronchopulmonary non-small-cell lung carcinoma cells (NSCLC-N6) with IC50 values of 〈 3.3-5.7 μg/mL. When tested against T leukemia virus type one (HTLV-I), compounds 1, 4 and 5 were found to exhibit slight anti-HIV activity.
Additional Material:
3 Tab.
Type of Medium:
Electronic Resource
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