Electronic Resource
Copenhagen
:
Munksgaard International Publishers
Experimental dermatology
10 (2001), S. 0
ISSN:
1600-0625
Source:
Blackwell Publishing Journal Backfiles 1879-2005
Topics:
Medicine
Notes:
Abstract: The production and its induction by ultraviolet radiation (UVR) of proopiomelanocortin (POMC)-derived peptides by keratinocytes has been reported, albeit not consistently. Recently we demonstrated that only under specific culturing conditions human keratinocytes are capable of producing a β-endorphin (βE)-like peptide with the characteristics of β-lipotropin (βLPH). Here the presence and UV-induction of βE-immunoreactivity (βE-IR) in keratinocytes in human skin in vivo was investigated. βE-IR was detectable by immunohistochemistry in keratinocytes of the follicular matrix and to some extent in cells of sweat ducts, but was absent from epidermal keratinocytes. Absence of βE-IR was confirmed by radioimmunoassay of HPLC-fractionated extracts of normal epidermis. Repeated exposure to solar-simulated UVR had no effect. This investigation is the first to demonstrate the presence of βE-immunoreactive material in the follicular matrix of corporal hairs and in duct cells of sweat glands. The possible meaning of these results is discussed.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1034/j.1600-0625.2001.100502.x
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