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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    World journal of surgery 5 (1981), S. 851-853 
    ISSN: 1432-2323
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    World journal of surgery 16 (1992), S. 313-319 
    ISSN: 1432-2323
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Résumé Avant de pratiquer un geste rationnel dans la cure du reflux gastro-oesophagien, il est nécessaire de poser le diagnostic de l'existence et de la cause du reflux. Le reflux gastro-oesophagien, c'est-à-dire, l'expositon de l'oesophage au suc gastrique, peut être dû soit à un défaut du sphincter inférieur de l'oesophage, soit à un défaut de clairance du reflux gastrique, soit encore à des anomalies du réservoir gastrique qui ont comme effet d'augmenter le reflux physiologique. La chirurgie anti-reflux a comme but de corriger le sphincter déficient, c'est-à-dire un sphincter dont la pression moyenne est inférieure à 6 mm Hg, une longueur d'oesophage exposée à la pression abdominale positive en moyenne inférieure à 1 cm, ou encore une longueur globale inférieure en moyenne à 2 cm. Dans notre expérience, ceci a été retrové chez 50 à 60% des patients ayant un reflux gastro-oesophagien. La chirurige n'est pas indiquée lorsqu'il existe une augmentation de l'exposition de l'oesophage au suc gastrique en rapport avec un défaut de clairance ou avec des anomalies gastriques. Par conséquent, il faut envisager un geste anti-reflux en face de symptomes persistants ou récidivants et/ou de complications du reflux gastro-oesophagien au delà de 8 semaines de traitement anti-secrétoire, la documentation objective d'une exposition accrue de l'oesophage au suc gastrique, mise en évidence par la pHmétrie, et al présence d'un sphincter inférieur de l'oesophage défectueux en manométrie. Chez les patients ainsi selectionnés, la fundoplicature selon Nissen est efficace chez 91% des patients à 10 ans.
    Abstract: Resumen Antes de proceder con una terapia quirúrgica racional de la enfermedad por reflujo gastroesofágico, es necesario establecer el diagnóstico objetivo de la presencia y causa de la enfermedad. La enfermedad por reflujo gastroesfágico, o sea la exposición anormalmente aumentada de la mucosa esofágica al jugo gástrico, puede ser ocasionada por un esfínter esofágico inferior defectuoso, por vaciamiento esofágico ineficaz del contenido gástrico que ha hecho reflujo y por anormalidades del reservorio estomacal que incrementan el reflujo fisiológico. La cirugía antirreflujo ha sido diseñada para corregir el esfínter mecánicamente defectuoso, o sea aquel con una presión media inferior a 6 mm Hg, con una longitud promedio del segmento expuesto a la presión positiva del abdomen menor de 1 cm, o una longitud total de menos de 2 cm. En nuestra experiencia esto se encuentra presente en aproximadamente 50 a 60% de los pacientes con enfermedad por reflujo gastroesofágico. La cirugía antirreflujo no está indicada en pacientes con exposición aumentada al jugo gástrico secundaria o vaciamiento ineficaz o a anormalidades gástricas. Por consiguiente, las indicaciones para proceder con un procedimiento antirreflujo son los síntomas persistentes y/o las complicaciones de la enfermedad por reflujo gastroesofágico después de 8 a 12 semanas de terapia intensa de supresión del ácido, la documentación objetiva de la exposición aumentada al jugo gástrico bajo monitoría continua de 24 horas del pH y la presencia de un esfínter esofágico inferior anormal según manometría. En los pacientes seleccionados mediante tales criterios, la fundoplicación de Nissen resulta en eficaz mejoría de los síntomas de reflujo en 91% de los pacientes con seguimiento a más de 10 años.
    Notes: Abstract Prior to any rational therapy of gastro-esophageal reflux disease, an objective diagnosis of the presence and the cause of the disease are necessary. Gastro-esophageal reflux disease, i.e., increased esophageal exposure to gastric juice, can be due to a mechanically defective lower esophageal sphincter, inefficient esophageal clearance of refluxed gastric contents, and abnormalities of the gastric reservoir that augment physiologic reflux. Antireflux surgery is designed to correct a mechanically defective sphincter, i.e., a sphincter with a mean pressure below 6 mm Hg, a mean length exposed to the positive pressure environment of the abdomen of less than 1 cm, or a mean overall length of less than 2 cm. In our experience, this is found in approximately 50% to 60% of patients with gastro-esophageal reflux disease. Antireflux surgery is not indicated in patients with increased esophageal exposure to gastric juice secondary to ineffective clearance or gastric abnormalities. Consequently, the indications to proceed with an antireflux procedure are persistent or recurrent symptoms and/or complications of gastro-esophageal reflux disease after 8 to 12 weeks of intensive acid suppression therapy, the objective documentation of increased esophageal exposure to gastric juice with 24 hour esophageal pH monitoring, and the presence of a mechanically defective lower esophageal sphincter on manometry. In patients selected according to these criteria, Nissen fundoplication provides effective relief of reflux symptoms in 91% of patients with more than 10 year follow-up.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    World journal of surgery 16 (1992), S. 1110-1110 
    ISSN: 1432-2323
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Springer
    World journal of surgery 12 (1988), S. 843-844 
    ISSN: 1432-2323
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Springer
    World journal of surgery 16 (1992), S. 335-336 
    ISSN: 1432-2323
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Résumé Afin d'aborder l'efficacité et les effets secondaires à long terme de la fundoplicature de Nissen dans le traitement chirurgical du reflux gastro-oesophagien, nous avons évalué 100 patients en période postopératoire. En respectant soigneusement les détails techniques qui sont décrits, l'incidence de la dysphagie transitoire postopératoire est de 39% et celle de la dysphagie persistante est de 3%. Les symptômes de reflux sont efficacement soulagés pendant plus de 10 ans chez 91% des patients avec des effets secondaires minimes.
    Abstract: Resumen Hemos valorado 100 pacientes postoperados con el objeto de estudiar la duración y los efectos secundarios a largo plazo de la fundoplicación de Nissen como modalidad terapéutica para la enfermedad por reflujo gastroesofágico. Con meticulosa atención a los detalles técnicos, como se describe, la incidencia de disfagia postoperatoria temporal fue 39% y de disfagia permanente 3%. El control de la sintomatología de reflujo se mantuvo en forma efectiva por más de 10 años en el 91% de los pacientes, quienes por lo demás presentaron mínimos efectos secundarios.
    Notes: Abstract To address the durability and long-term side effects of the Nissen fundoplication as surgical therapy for gastroesophageal reflux disease, we evaluated 100 patients postoperatively. With careful attention to technical detail as described, the incidence of temporary postoperative dysphagia was 39% and permanent dysphagia was 3%. Effective relief of reflux symptoms over more than 10 years was achieved in 91% of the patients with minimal side effects.
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    Springer
    World journal of surgery 17 (1993), S. 594-594 
    ISSN: 1432-2323
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 7
    Electronic Resource
    Electronic Resource
    Springer
    World journal of surgery 2 (1978), S. 857-858 
    ISSN: 1432-2323
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 8
    Electronic Resource
    Electronic Resource
    Springer
    Dysphagia 11 (1996), S. 252-253 
    ISSN: 1432-0460
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 9
    ISSN: 1534-4681
    Keywords: Reflux ; Dietary fat ; Barrett's esophagus ; Esophageal cancer
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Background: Reflux of duodenal content into the lower esophagus of rats enhances the formation of nitrosamine-induced esophageal cancer and results in the induction of adenocarcinoma. We investigated the extent of the mucosal injury that was produced when the lower esophagus of rats was exposed to the reflux of gastroduodenal juice in the presence or absence of a carcinogen and tested the hypothesis that induction of esophageal cancer in this model would be influenced by the intake of dietary fat. Methods: Esophagoduodenostomy with gastric preservation was performed in 165 Sprague-Dawley rats in order to expose the lower esophagus to the reflux of gastroduodenal juice. Postoperatively selected groups of rats were treated with the carcinogen methyl-n-amylnitrosamine (MNAN). Subsequently, rats were fed diets of differing fat and calorie content for 20 weeks until they were put to death. Results: Refluxed gastroduodenal juice, in the absence of MNAN, induced esophageal inflammatory changes (diffuse papillomatosis and hyperkeratosis) in 38 of 39 rats (97%), specialized columnar metaplasia (Barrett's esophagus) in four of 39 (10%), dysplasia in three of 39 (8%), and squamous cell carcinoma in one of 39 (3%). Diet did not influence the incidence of neoplasia in the absence of MNAN treatment. In rats treated with MNAN, refluxed gastroduodenal juice induced inflammation in 110 of 111 rats (99%), columnar metaplasia in 14 of 111 (13%), and cancer in 63 of 111 (57%). Fifty-eight percent of esophageal tumors were squamous cell carcinoma and 42% were adenocarcinoma. The highest incidence of tumors was observed in rats fed the semipurified high-fat diet (24 of 29; 83%) compared with rats fed the semipurified control diet (13 of 29; 45%), semipurified, calorie-restricted diet (15 of 27; 55%), and chow diet (11 of 26; 42%), p〈0.05. Conclusions: Reflux of gastroduodenal content into the lower esophagus of rats can induce both Barrett's metaplasia and neoplasia. Addition of a carcinogen increases the tumor yield and results in a proportion of the lesions being adenocarcinoma. This carcinogenic process is promoted by a diet with a high fat content.
    Type of Medium: Electronic Resource
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  • 10
    Electronic Resource
    Electronic Resource
    Springer
    Digestive diseases and sciences 37 (1992), S. 849-856 
    ISSN: 1573-2568
    Keywords: gastroesophageal reflux disease ; 24-hr pH tests ; esophageal tests ; ambulatory monitoring
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Although the most sensitive and specific test for diagnosing gastroesophageal reflux disease, normal standards for prolonged esophageal pH monitoring are based on small sample sizes with questions raised about the effects of pH electrode, older age, gender, and methods of data analysis on pH variables. Recently three groups have established normal data bases using similar methodology. Multiple regression and nonparametric analyses showed that the values for the six traditional pH parameters were comparable across study centers. Therefore, the groups were combined for a total study population of 110 healthy subjects (47 men, 63 women, mean age 38 years with a range of 20–84 years). Further nonparametric analyses revealed the following: (1) type of pH electrode (antimony vs glass) is not significantly related to parameters of physiologic acid reflux; (2) age is not independently related to pH parameters; (3) men tend to have more physiologic reflux than women; and (4) older men tend to experience longer episodes of reflux than younger men and women. There was a significant effect of gender and a significant interaction between age and gender on the number of episodes 〉5 min (P=0.008). Nearly significant differences were found for percentage of total acid exposure time (P=0.03), total reflux episodes (P=0.02), and the longest reflux episode (P=0.02). We believe these normal esophageal pH values can be used confidently as standards in any laboratory, and consideration should be given to developing separate standards for men and women.
    Type of Medium: Electronic Resource
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