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  • 1
    Electronic Resource
    Electronic Resource
    Visual toxicity following intra-arterial chemotherapy with hydroxyethyl-CNU in patients with malignant gliomas (1991)
    Springer
    Neuroradiology 33 (1991), S. 432-437 
    Details
    ISSN: 1432-1920
    Keywords: Nitrosourea ; Glioma ; Intra-arterial chemotherapy ; Ischemic optic neuropathy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary We studied the effects of intra-arterial chemotherapy (IAC) with a new nitrosourea (hydroxyethyl-chloroethyl nitrosourea: HeCNU) on the visual system of 68 patients with malignant gliomas. The intra-arterial chemotherapy was given as a complementary treatment of glioma after surgery (19 patients), after tumor recurrence (28 patients) and as the preliminary treatment before radiotherapy (21 patients). Eleven patients (16%) suffered a visual complication after two or more courses of chemotherapy. The main visual symptoms included mild to major decrease of visual acuity and in some cases ocular pain, palpebral edema and conjunctival injection. The delay in onset of ocular symptoms from the last course of IAC varied from 1 week to 9 months. From ophthalmoscopic findings, visual field testing and fluorescein angiography, the visual symptoms presented by our patients could be related to ischemic optic neuropathy or retinal vasculopathy. None of the patients had hypertension, diabetes, cardiopathy or hematological disease. Statistical analysis failed to demonstrate a relationship between the occurrence of visual toxicity and patient age, number of courses of HeCNU, the vascular axis treated, total systemic dose or dose by carotid artery, suggesting a possible specific sensitivity of some patients to chemotherapy. The pathophysiology and the therapeutic implications of this visual toxicity are discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00598619
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Lyme disease presenting as a stroke in the vertebrobasilar territory: MRI (1993)
    Springer
    Neuroradiology 35 (1993), S. 529-531 
    Details
    ISSN: 1432-1920
    Keywords: Stroke ; Lyme disease ; Magnetic resonance imaging
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract A 28-year-old female farmer, without vascular risk factors, developed a limited infarct of the pons, associated with a lymphocytic cerebrospial fluid (CSF) pleocytosis. Titres of specific antibodies againstBorrelia burgdorferi were high in serum and CSF. MRI confirmed an infarct in the territory of the medial pontine arteries, but angiography showed no, evidence of cerebral angiopathy. Antibiotic therapy rapidly led to a return to normal of CSF cytology and serology. We suggest that Lyme disease is a possible cause of cerebral ischaemia.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00588714
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Effect of nifedipine on plasma catecholamines in man at rest and during exercise (1986)
    Springer
    European journal of clinical pharmacology 30 (1986), S. 727-729 
    Details
    ISSN: 1432-1041
    Keywords: nifedipine ; plasma adrenaline ; plasma noradrenaline ; exercise ; blood pressure ; heart rate
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary Blood pressure, heart rate, and plasma catecholamine concentrations were measured in 9 normotensive volunteers during a randomized cross-over study of oral nifedipine (10 mg×5) and placebo; measurements were made at rest and during maximal anaerobic exercise. At rest nifedipine reduced blood pressure and increased heart rate and plasma noradrenaline, whereas plasma adrenaline did not change. During exercise, the blood pressure response was similar in nifedipine and placebo treated subjects; however, heart rate was significantly higher with nifedipine. Plasma noradrenaline increased more during exercise in nifedipine-treated subjects. By contrast, nifedipine inhibited the increase in plasma adrenaline induced by exercise. The results suggest that peripheral vasodilatation induced by nifedipine is responsible for increased sympathetic nerve activity, both at rest and during exercise, and that nifedipine inhibits adrenaline secretion in man.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00608224
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Hormonal and metabolic response to physical exercise, fasting and cold exposure in the rat (1988)
    Springer
    European journal of applied physiology 57 (1988), S. 114-119 
    Details
    ISSN: 1439-6327
    Keywords: Prolonged physical exercise ; Fasting ; Cold exposure ; Ketogenesis ; Pancreatic hormones
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Four groups of rats were subjected to the following conditions: (1) 48 h fasting, (2) 48 h of 4°C cold exposure, (3) 5 h treadmill running, (4) 48 h fasting with 4°C cold exposure. The groups were compared to fed control rats in order to study hormonal and metabolic responses in blood and tissue samples. Isolated hepatocytes were used to evaluate the rate of ketogenesis. Decreases in liver glycogen and increases in blood free fatty acids (FFA) confirmed that glycogenolysis and lipolysis occur in these situations of metabolic stress. Increases in the glucagon/insulin plasma ratio were also noted. Plasma catecholamine levels were only enhanced after running and after cold exposure. Production of blood ketone bodies was stimulated more by running and by fasting than by cold exposure. The low ketone body production observed after cold exposure seems to be linked to increases liver glycogen levels and decreased FFA availability. Liver cells isolated after cold exposure exhibited higher ketogenesis than these isolated after running. This difference in ketogenic capacity could result both from the longer hormonal stimulation by high glucagon/insulin plasma ratios and from the metabolic state of the liver.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00691249
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    Paper (German National Licenses)
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  • 5
    Electronic Resource
    Electronic Resource
    Plasma renin activity, aldosterone and catecholamine levels when swimming and running (1986)
    Springer
    European journal of applied physiology 54 (1986), S. 632-637 
    Details
    ISSN: 1439-6327
    Keywords: Plasma catecholamines ; Plasma renin activity ; Plasma aldosterone ; Swimming ; Running
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The purpose of this study was to determine the response of plasma renin activity (PRA), plasma aldosterone concentration (PAC) and catecholamines to two graded exercises differing by posture. Seven male subjects (19–25 years) performed successively a running rest on a treadmill and a swimming test in a 50-m swimming pool. Each exercise was increased in severity in 5-min steps with intervals of 1 min. Oxygen consumption, heart rate and blood lactate, measured every 5 min, showed a similar progression in energy expenditure until exhaustion, but there was a shorter time to exhaustion in the last step of the running test. PRA, PAC and catecholamines were increased after both types of exercise. The PRA increase was higher after the running test (20.9 ng AngI · ml−1 · h−1) than after swimming (8.66 ng AngI · ml−1 · h−1). The PAC increase was slightly greater after running (123 pg · ml−1) than swimming (102 pg · ml−1), buth the difference was not significant. Plasma catecholamine was higher after the swimming test. These results suggest that the volume shift induced by the supine position and water pressure during swimming decreased the PRA response. The association after swimming compared to running of a decreased PRA and an enhanced catecholamine response rule out a strict dependence of renin release under the effect of plasma catecholamines and is evidence of the major role of neural pathways for renin secretion during physical exercise.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00943352
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    Paper (German National Licenses)
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