ISSN:
1436-2813
Keywords:
ICAM-1
;
LFA-1
;
liver transplantation
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract The effect of the anti-cell adhesion molecule anti-bodies, anti-ICAM-1 (1A29) and anti-LFA-1 (WT1), on rat liver transplantation was investigated. Livers from ACI rats were transplanted into Lewis rats by Kamada's method and during the recipient operation 1A29 1 mg/kg, and WT1 1 mg/kg were administered intravenously to one group of rats (treated group). The survival time of the treated group was significantly longer than that of the untreated group, but permanent unresponsiveness could not be induced. Postmortem examination revealed little histological evidence of acute rejection in the treated rats, in which the main cause of death was thought to be chronic rejection.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00311833
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