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  • 1
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    Journal of Steroid Biochemistry 28 (1987), S. 45 
    ISSN: 0022-4731
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    Journal of Steroid Biochemistry 28 (1987), S. 45 
    ISSN: 0022-4731
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 1432-5195
    Keywords: Bone cancer ; Bone reconstruction ; Massive allografts
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Résumé Soixante-dix-neuf allogreffes massives, conservées à froid doux et stérilisées par irradiation, ont permis de reconstruire les larges défects osseux (taille moyenne 20,5 cm) secondaires à la chirurgie d'exérèse de cancers des membres de haut degré de malignité. Trois infections profondes, 8 pseudarthroses (dont 4 guéries après réintervention) et 4 fractures secondaires d'allogreffes ont compliqué les suites opératoires. A la dernière consultation, le résultat fonctionnel a pu être évalué dans 72 cas: excellent pour 30 (40%), très bon pour 22 (29%), bon pour 13 (18%), médiocre pour 3 (4%), mauvais pour 4 (5%). Des anticorps anti-greffes ont été mis en évidence dans 3 cas, sans conséquence radiologique ou clinique apparente. Les scintigraphies osseuses répétées montrent la revascularisation progressive des allogreffes par les muscles avoisinants. La réinsertion musculaire paraît réelle à l'examen clinique de tous les patients et a été prouvée par l'aspect opératoire et histologique des cas réopérés. Cette réinsertion musculotendineuse explique l'amélioration de l'état fonctionnel. En conclusion les reconstructions par allogreffes stérilisées par rayon ß et habillant des prothèses à longue queue en titane ou des clous pleins cimentés, donnent un meilleur résultat fonctionnel que les prothèses massives métalliques et méritent d'être utilisées chaque fois que l'espérance de vie du malade est suffisante.
    Notes: Summary We have used massive allografts, preserved by freezing to −30° C and sterilised by irradiation, to reconstruct large defects in bone after resection of high grade neoplasms. The average length of the defect was 20.5 cm. Complications included 3 deep infections, 8 pseudoarthroses, of which 4 joined after further operation and 3 are still under treatment, and 4 late fractures of the graft. Seventy two cases have been followed up, and the functional result was excellent in 30, very good in 22, good in 13, poor in 3 and bad in 4. In 3 cases H. L. A. antibodies against the graft have been detected, but no clinical or radiological abnormality was noted. Bone scintigraphy showed progressive revascularisation of the graft from surrounding muscle. Reattachment of muscles to the allografts was successful, and contributed to the good functional results. Reconstruction with sterilised allografts, in association with long stemmed titanium prostheses or a cemented nail, gave a better functional results than using massive stainless steel prostheses in patients with a reasonable life expectancy.
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Springer
    International orthopaedics 22 (1998), S. 27-31 
    ISSN: 1432-5195
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Résumé. La résection du sarcome osseux des membres inférieurs chez l’enfants est très souvent suivie par une inégalité progressive de longueur des membres résultant de la perte du cartilage de croissance. Pour maîtriser ceci nous avons utilisé une prothèse expansive et nous rapportons notre expérience durant la période 1985 – 1996. Les prothèses sont en titane et comprennent 3 parties: le composant articulaire, le mécanisme d’expansion et les tiges fémorale et tibiale. La possibilité d’allongement de la prothèse est, théoriquement, sans limite et elle peut être implantée chez l’enfant de 5 ans ou plus. Nous rapportons une série de 28 prothèses chez des patients âgés de 5 à 18 ans. 5 étaient pour résection tibiale, 5 pour fémur total et 16 pour résection du fémur distal. Il y avait 6 sarcomes d’ewing, 21 ostéosarcomes et 1 synovialosarcome. Le délai moyen d’observation était de 5 ans. 5 patients sont décédés de leur maladie et 21 ont bénéficié d’un allongement moyen de 2,6 cms (2 mm – 120 mm). En utilisant les critères de la Société Européenne des Tumeurs Osseuses (EMSOS), les résultats fonctionnels ont été trouvés excellents ou très bons dans 16 cas, moyens dans 7 et mauvais dans 5. 5 patients ont eu des suites infectieuses, ce qui a nécessité l’amputation dans 1 cas et chez les autres, une réintervention avec implantation d’une nouvelle prothèse expansive. Nous concluons qu’une prothèse expansive est une très bonne alternative à l’amputation chez le jeune enfant. Cependant, le risque d’infection liéà la chirurgie répétée nous conduit à développer une prothèse qui puisse être allongée de fa*on externe, sans nécessiter de nouvelle intervention chirurgicale.
    Notes: Summary. Conservative resection of bone sarcoma in the lower limbs in children is very likely to be followed by a progressive problem of leg length inequality resulting from removal of the growth cartilage. To overcome this we have been using an expanding prosthesis and we report our experiences during the period 1985 – 1996. The prostheses are made of titanium and comprise 3 parts: an articular component, an expanding mechanism, and tibial and femoral stems. The degree of possible lengthening of the prostheses is virtually unlimited, and they can be inserted in children of 5 or more years of age. We report the use of 28 prostheses in patients aged from 5 to 18 years, of which 4 were tibial, 5 total femur, and 16 distal femur. There were 6 Ewing’s sarcoma, 21 osteosarcoma, and 1 synovial sarcoma. The average follow-up was for 5 years. Five patients died from their disease, and 21 benefited from an average lengthening of 2.6 cm (range: 2 mm – 120 mm). Using the Société Européenne des Tumeurs Osseouses (EMSOS) criteria, the functional results were excellent or very good in 16, fair in 7 and bad in 5. Five patients developed an infection; one required amputation and the others received a new expanding prosthesis. We conclude that an expanding prosthesis is an excellent alternative to amputation in young children. However, the risk of infection associated with repeat surgery has led us to develop a prosthesis which can be lengthened externally, without the need for reopening the wound.
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    s.l. : American Chemical Society
    The @journal of organic chemistry 59 (1994), S. 7517-7520 
    ISSN: 1520-6904
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    European journal of neuroscience 9 (1997), S. 0 
    ISSN: 1460-9568
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Using a monoclonal antibody (6.17) directed against a Schwann antigen, we have shown that Schwann cells synthesize a molecule implicated in a change of expression of synaptic cholinesterases, AChE and BChE, during muscle differentiation. In vitro, during synaptogenesis, the two enzymes are first present at developing synapses, and addition of Schwann cells to muscle-neuron co-cultures induces a disappearance of BChE, leaving only AChE activity as in the adult neuromuscular junction. This effect is inhibited by the 6.17 antibody. Thus, a molecule produced by Schwann cells is involved in the maturation of the neuromuscular synapse, in addition to the neuronal factors (CGRP, ARIA/heregulin, agrin), which are known to control the synthesis, maturation and accumulation of acetylcholine receptors and other synaptic components. In addition, in vivo, in the newborn rat, butyrylcholinesterase and acetylcholinesterase activities are initially present in equal amounts in the neural zone, but butyrylcholinesterase levels diminish sharply between 7 and 15 days after birth, the stage at which the synaptic Schwann cell membrane becomes juxtaposed with the muscle membrane.
    Type of Medium: Electronic Resource
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  • 7
    ISSN: 1546-1718
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Medicine
    Notes: [Auszug] Congenital generalized lipodystrophy, or Berardinelli–Seip syndrome (BSCL), is a rare autosomal recessive disease characterized by a near-absence of adipose tissue from birth or early infancy and severe insulin resistance. Other clinical and biological features include acanthosis nigricans, ...
    Type of Medium: Electronic Resource
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  • 8
    ISSN: 1546-1718
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Medicine
    Notes: [Auszug] Wolcott-Rallison syndrome (WRS) is a rare, autosomal recessive disorder characterized by permanent neonatal or early infancy insulin-dependent diabetes. Epiphyseal dysplasia, osteoporosis and growth retardation occur at a later age. Other frequent multisystemic manifestations include hepatic and ...
    Type of Medium: Electronic Resource
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  • 9
    Electronic Resource
    Electronic Resource
    [s.l.] : Nature America Inc.
    Nature genetics 23 (1999), S. 270-271 
    ISSN: 1546-1718
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Medicine
    Notes: [Auszug] Genetic analysis is necessary to understand the molecular basis of the association between polymorphisms of DCP1 (encoding the human angiotensin-1 converting enzyme (ACE)), cardiovascular disease and quantitative variation of circulating ACE activity. The recent sequencing of 24 kb of DCP1 in ...
    Type of Medium: Electronic Resource
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  • 10
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    Journal of Chromatography A 161 (1978), S. 386-388 
    ISSN: 0021-9673
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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