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  • 1
    Electronic Resource
    Electronic Resource
    Review article: transcription factors and growth factors in ulcer healing (2000)
    Oxford, UK : Blackwell Science Ltd
    Alimentary pharmacology & therapeutics 14 (2000), S. 0 
    Details
    ISSN: 1365-2036
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: This review is focused on recent investigations demonstrating a pharmacological and patho-physiologic role in gastroduodenal ulceration for growth factors such as basic fibroblast growth factor (bFGF), platelet-derived growth factor (PDGF) and vascular endothelial growth factor (VEGF), as well as for transcription factors. Our experiments revealed accelerated healing, without decreased gastric acid secretion, of chronic cysteamine-induced duodenal ulcers in rats treated daily for 3 weeks with intragastric administration of bFGF, PDGF or VEGF. Our recent studies also indicate a pathophysiological role of endogenous growth factors in the natural history of experimental duodenal ulcer development and healing.More recently, we investigated the genetic regulation of these growth factors in experimental duodenal ulceration. Since gene expression is most effectively controlled by transcription factors, proteins that bind to cis-acting elements of DNA and guide the binding of polymerase II to start the transcription of specific mRNA, we tested the hypothesis that the expression of IEGs and their transcription factor products, such as Egr-1 and Sp1, might precede the increased synthesis of bFGF, PDGF and VEGF in duodenal ulcer healing. Indeed, the duodenal ulcerogen cysteamine, but not its nonulcerogen and toxic analogue ethanolamine, rapidly increased duodenal (but not gastric) mucosal levels of ET-1, which was followed by enhanced expression of Egr-1 and a decrease in Sp1 in the preulcerogenic stage of duodenal ulceration. These changes in levels of ET-1 and expression of transcription factors were also accompanied by increased expression of the CDK inhibitor p21. Thus, not only growth factors such as bFGF, PDGF and VEGF, but also transcription factors such as Egr-1 and Sp1 and the cell cycle regulator p21, may play a role in the natural history of experimental duodenal ulceration.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1365-2036.2000.014s1033.x
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  • 2
    Electronic Resource
    Electronic Resource
    Gene Therapy Accelerates Chronic Duodenal Ulcer Healing in Rats Using VEGF and PDGF Naked DNA or Adenoviral Plasmids (1999)
    [s.l.] : Nature America, Inc.
    Nature biotechnology 17 (1999), S. 36-37 
    Details
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Gene therapy has been investigated and used for the treatment for malignant tumors and ischemic diseases in both animal models and clinical settings. Previously, effective ulcer healing with intragastric administration of growth factors such as VEGF (vascular endothelial growth factor) and PDGF ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/70170
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  • 3
    Electronic Resource
    Electronic Resource
    Synthesis and characterization of block copolymers from D, L-lactide and poly(ethylene glycol) with stannous chlorideThe project was supported by the National Natural Science Foundation of China. (1990)
    New York : Wiley-Blackwell
    Journal of Polymer Science: Polymer Letters Edition 28 (1990), S. 411-416 
    Details
    ISSN: 0887-6258
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Additional Material: 4 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/pol.1990.140281303
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  • 4
    Electronic Resource
    Electronic Resource
    Synthesis and characterization of block copolymers from D,L-lactide and poly(tetramethylene ether glycol) (1995)
    New York, NY [u.a.] : Wiley-Blackwell
    Journal of Applied Polymer Science 55 (1995), S. 865-869 
    Details
    ISSN: 0021-8995
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics
    Notes: The copolymer from D,L-lactide and poly(tetramethyene ether glycol) (PTMG) was prepared in bulk with an isotributyl aluminum-water-phosphoric acid complex catalyst as the initiator and characterized by H-NMR, GPC, and DSC. The effects of the temperature and the amount of PTMG on the polymerization rate and the molecular weight of copolymers were studied. The behavior of the degradation and delivery rate of Levonorgestrel microspheres in vitro was observed. The results show that the degradation and the delivery rate can be controlled by adjusting the molar rate of hydrophilic and hydrophobic segments of the copolymer © 1995 John Wiley & Sons, Inc.
    Additional Material: 4 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/app.1995.070550604
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  • 5
    Electronic Resource
    Electronic Resource
    Studies on the block copolymerization of D,L-lactide and poly(ethyle glycol) with aluminium complex catalyst (1995)
    New York, NY [u.a.] : Wiley-Blackwell
    Journal of Applied Polymer Science 55 (1995), S. 1193-1196 
    Details
    ISSN: 0021-8995
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics
    Notes: A series of block copolymers from D,L-lactide and poly(ethylene glycol) (PEG) with different molecular weight were synthesized by using Al(i-Bu)3—H3PO4—H2O as the initiator and identified by 1H-NMR, GPC, and DSC. The elongation at break of the material increased when PEG was introduced, but the strength of the material decreased. The copolymers degrade more smoothly in vitro than did the PLA homopolymer. © 1995 John Wiley & Sons, Inc.
    Additional Material: 4 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/app.1995.070550806
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