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  • 1
    Electronic Resource
    Electronic Resource
    Effects of Drugs on Uptake of Isotopic Norepinephrine by Cat Tissues (1961)
    [s.l.] : Nature Publishing Group
    Nature 191 (1961), S. 816-817 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] The present experiments were undertaken in the hope that the effects of several drugs on the uptake of norepinephrine may be related to their pharmacological effects. Slices of cat tissue were incubated for 45 min. in Krebs bicarbonate medium containing the appropriate drug and 5 ni(igm. of ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/191816a0
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  • 2
    Electronic Resource
    Electronic Resource
    Endogenous ligand(s) decrease drug — Protein binding in uremic sera: A fluorescence probe study (1983)
    Springer
    Journal of molecular medicine 61 (1983), S. 649-653 
    Details
    ISSN: 1432-1440
    Keywords: Drug protein binding ; Uremia ; Fluorescence probe techniques ; Human serum albumin
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Human serum albumin (HSA) was isolated and purified (〉97% purity) from normal sera, from sera of patients with severe chronic renal insufficiency and from sera to which a strongly protein bound acidic drug — clofibrinic acid — was added as a model ligand. The binding properties were evaluated using dansylglycine as a fluorescent probe. Data were analyzed according to Scatchard, the binding constants were calculated by least square approximation. The binding of dansylglycine to HSA from uremic sera was substantially decreased, reflected mainly by a lower productn 1·K 1, as was the binding of dansylglycine to HSA from model sera containing clofibrinic acid. The binding was restored to almost normal when HSA was treated with charcoal. It is concluded that the impaired binding of many mostly acidic drugs to HSA in uremia is due to the presence of endogenous ligands. In addition a minor contribution by changes in HSA structure cannot be excluded.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01487581
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  • 3
    Electronic Resource
    Electronic Resource
    Report of a workshop on fixed-ratio drug combinations (1975)
    Springer
    European journal of clinical pharmacology 8 (1975), S. 149-154 
    Details
    ISSN: 1432-1041
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00561565
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  • 4
    Electronic Resource
    Electronic Resource
    In memoriam: Franz Gross 14 February 1913–26 March 1984 (1984)
    Springer
    European journal of clinical pharmacology 26 (1984), S. 411-411 
    Details
    ISSN: 1432-1041
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00542132
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  • 5
    Electronic Resource
    Electronic Resource
    Diazepam absorption (1982)
    Springer
    Digestive diseases and sciences 27 (1982), S. 225-230 
    Details
    ISSN: 1573-2568
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The kinetics of diazepam absorption were assessed in 37 healthy volunteers, aged 19–79 years, who ingested a single 5-mg tablet in the fasting state. Diazepam plasma concentrations were measured by gas chromatography in multiple samples drawn over the next 72 hr. After a lag time averaging 12 min elapsed between tablet ingestion and the start of absorption, first-order absorption proceeded with a mean half-life of 19 min (range: 0–96 min), with peak plasma concentrations reached 0.9 hr after dosage (range: 0.25–2.5 hr). Age and sex did not influence absorption kinetics. Peak plasma concentrations averagd 157 ng/ml, and tended to be higher in women than in men because of lower body weights in women. Peak levels also declined with age, probably due to increased volume of distribution of diazepam in the elderly. Absolute systemic availability of oral diazepam was evaluated in seven of the subjects who received intravenous diazepam on another occasion. Based on areas under the oral versus intravenous plasma concentration curve, bioavailability of diazepam averaged 97%. Six male patients, at least 2 years after undergoing Billroth gastrectomy, also participated in the diazepam absorption study. Absorption kinetic parameters were nearly identical to those in six healthy agematched male volunteers without gastrointestinal disease. Thus absorption of oral diazepam in the fasting state is rapid and nearly complete, and is minimally influenced by age, sex, or Billroth gastrectomy.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01296920
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  • 6
    Electronic Resource
    Electronic Resource
    Zur Hemmung der L-Glutaminsäure-und L-Dopadecarboxylase durch D-Cycloserin und andere Isoxazolidone (1962)
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 243 (1962), S. 366-381 
    Details
    ISSN: 1432-1912
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary 1. D-Cycloserine, an antibiotic produced by different strains of Streptomyces, to which frequent side effects on the central nervous system—particularly seizures and psychotic reactions—are attributed, inhibits the pyridoxal-5-phosphate dependent enzymes L-glutamic acid- and L-dopadecarboxylase in vitro. Additional data for some structurally related isoxazolidones are presented, among which 2,5-bis-(aminoxy-methyl)-1,4-dioxopiperazine, a spontaneous degradation product of D-cycloserine, was the most active compound. 2. It can be demonstrated by kinetic analysis, that the inhibition of the L-dopadecarboxylase is due to competition of the coenzymatically inactive (pyridoxalphosphate-cycloserine)-complex with the free pyridoxal-5-phosphate for the apoenzyme thus diminishing the formation of the active holoenzyme. Numerical figures for the different equilibria-constants are given. 3. The implications of these findings for the central nervous toxicity of D-cycloserine are discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00244921
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  • 7
    Electronic Resource
    Electronic Resource
    Absorption of oral tetracycline in patients with Billroth-II gastrectomy (1978)
    Springer
    Journal of pharmacokinetics and pharmacodynamics 6 (1978), S. 295-303 
    Details
    ISSN: 1573-8744
    Keywords: tetracycline ; antibiotics ; Billroth-II gastrectomy ; gastrectomy ; pharmacokinetics ; bioavailability
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract The bioavailability of a single 250-mg oral dose of tetracycline hydroghloride was studied in seven patients following Billroth-II gastrectomy in comparison with seven control subjects matched for age and body weight. There were no significant differences between control subjects and gastrectomized patients in the apparent lag time prior to the start of absorption (23.6 vs. 22.8 min), peak serum tetracycline concentration (1.72 vs. 1.75 μg/ml), the time of attainment of peak concentrations (3.35 vs. 3.42 hr), the apparent first-order absorption half-life (1.8 vs. 1.4hr), or the apparent first-order elimination half-life (8.0 vs. 8.7hr). Completeness of tetracycline absorption, as judged by area under the 24-hr serum concentration curve, did not differ significantly between the two groups, nor did 24-hr urinary excretion of tetracycline. Thus the abnormalities of gastrointestinal structure and function produced by Billroth -II gastrectomy do not result in impairment of the rate and completeness of tetracycline absorption.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01060093
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