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  • 1
    Electronic Resource
    Electronic Resource
    PEROXISOME PROLIFERATOR-ACTIVATED RECEPTORS: A Nuclear Receptor Signaling Pathway in Lipid Physiology (1996)
    Palo Alto, Calif. : Annual Reviews
    Annual Review of Cell and Developmental Biology 12 (1996), S. 335-363 
    Details
    ISSN: 1081-0706
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Biology , Medicine
    Notes: Abstract Peroxisome proliferator-activated receptors (PPARs) are lipid-activated transcription factors that belong to the steroid/thyroid/retinoic acid receptor superfamily. All their characterized target genes encode proteins that participate in lipid homeostasis. The recent finding that antidiabetic thiazolidinediones and adipogenic prostanoids are ligands of one of the PPARs reveals a novel signaling pathway that directly links these compounds to processes involved in glucose homeostasis and lipid metabolism including adipocyte differentiation. A detailed understanding of this pathway could designate PPARs as targets for the development of novel efficient treatments for several metabolic disorders.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1146/annurev.cellbio.12.1.335
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Retinaldehyde: more than meets the eye (2007)
    [s.l.] : Nature Publishing Group
    Nature medicine 13 (2007), S. 671-673 
    Details
    ISSN: 1546-170X
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Medicine
    Notes: [Auszug] The identification of nuclear receptors defined a new paradigm: small lipophilic hormones specifically bind their cognate receptor and the complex directly regulates the expression of multiple targets. The genes controlled by these activated nuclear receptor transcription factors are diverse, and ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/nm0607-671
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Roles of PPARs in health and disease (2000)
    [s.l.] : Macmillian Magazines Ltd.
    Nature 405 (2000), S. 421-424 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] In developed societies, chronic diseases such as diabetes, obesity, atherosclerosis and cancer are responsible for most deaths. These ailments have complex causes involving genetic, environmental and nutritional factors. There is evidence that a group of closely related nuclear receptors, called ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/35013000
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    Paper (German National Licenses)
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