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  • 1
    Electronic Resource
    Electronic Resource
    Variations in the serum concentration and urine excretion ofα 2HS-glycoprotein, a bone-related protein, in normal individuals and in patients with osteogenesis imperfecta (1983)
    Springer
    Calcified tissue international 35 (1983), S. 16-20 
    Details
    ISSN: 1432-0827
    Keywords: α 2HS-Glycoprotein ; Bone protein ; Serum ; Urine ; Osteogenesis imperfecta
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine , Physics
    Notes: Summary The concentration ofα 2HS-glycoprotein was measured in the serum and urine of normal individuals and of patients with osteogenesis imperfecta. The serum concentration ofα 2HS-glycoprotein was higher in normal children than in adults. In women values showed a progressive agerelated decrease, from 632 mg/l at 21–30 years to 573 mg/l at 51–60 years. In men there was no such age-related variation, and values were higher than in women of comparable age; the mean value for men aged 20–60 years was 648 mg/l. Of 48 patients with osteogenesis imperfecta, 11 had an abnormally high concentration ofα 2HS-glycoprotein in serum; the cause of this is not clear. In urine of 24 normal individuals the mean value of the ratio albumin:α 2HS-glycoprotein was 20±3; in serum the corresponding ratio was 70. Urine excretion ofα 2HS-glycoprotein was lowest in female children (132±29 µg/24 h) and highest in male adults (592±91 µg/24 h); values in patients with osteogenesis imperfecta did not differ from normal.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02405000
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    The influence of dihydroxylated vitamin D metabolites on bone formation in the chick (1984)
    Springer
    Calcified tissue international 36 (1984), S. 114-122 
    Details
    ISSN: 1432-0827
    Keywords: 1,25(OH)2D3 ; 24,25(OH)2D3 ; Vitamin D3 ; Vitamin D-deficiency
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine , Physics
    Notes: Summary The ability of 1,25(OH)2D3 and of 24,25(OH)2D3 to prevent or to heal rickets in chicks was evaluated by studies of plasma biochemistry, growth plate histology, bone morphometry and microradiography, and bone mineralization. 1,25(OH)2D3 at a dose of 100 ng/day produced fewest abnormalities compared with vitamin D3-treated control chicks. Bone growth was slightly greater than vitamin D3-treated controls in chicks given a lower dose of this metabolite; the reverse was observed in chicks given a higher dose. 24,25(OH)2D3 was less effective than 1,25(OH)2D3 in preventing rickets even at doses as high as 400 ng/day. Treatment of rachitic chicks with doses of 24,25(OH)2D3 up to 300 ng/day produced no healing effect on the bone lesions, in marked contrast to the beneficial effects observed with 1,25(OH)2D3.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02405303
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Effects of demineralization in an ethanolic solution of triethylammonium EDTA on solubility of bone matrix components and on ultrastructural preservation (1980)
    Springer
    Calcified tissue international 32 (1980), S. 175-179 
    Details
    ISSN: 1432-0827
    Keywords: Decalcification ; Electron microscopy ; Bone matrix ; Bone glycoproteins
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine , Physics
    Notes: Summary A solution of triethylammonium EDTA in 80% ethanol was evaluated as a demineralizing reagent for bone in comparison with aqueous solutions of EDTA. Biochemical analysis and acrylamide gel electrophoresis of extracts of finely powdered bovine bone showed that most of the macromolecular components of the organic matrix extractable in aqueous EDTA were retained when the triethylammonium EDTA reagent was used. Ultrastructural examination of chick tibias decalcified with the reagents showed a better preservation of cellular morphology, especially the membranous components, and more uniformly distributed ground substance, though slightly less in quantity, when the aqueous reagent was used. Use of the two reagents appears to be complementary, the alkylammonium reagent being more appropriate for use in studies of the organic matrix of bone, including immunohistochemical studies of bone glycoproteins. The aqueous reagent is more appropriate for use in studies of cellular ultrastructure.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02408537
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    Paper (German National Licenses)
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