ISSN:
1432-0584
Keywords:
ITP
;
Intravenous gamma globulin therapy
;
111In-labelled platelets
;
Platelet release into the circulation
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary The kinetics and distribution in vivo of 111In-labelled platelets prior to and during intravenous high-dose gamma globulin therapy in a 3-months-old child with idiopathic thrombocytopenic purpura were evaluated. Concomitantly with a prompt increase in platelet concentration we found evidence for release of platelets into the circulation, presumably to a large extent originating from the spleen and liver. Our results support the concept that, in response to high-dose gamma globulin therapy, platelets are not only forced to remain in but are also released into the circulation, presumably as a result of mobilization of platelets adhering to cells of the monocyte-macrophage system.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00320714
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